Structural Biology And Lead Discovery Consultant
Brent Appleton Scientific Consulting Llc
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Brent Appleton Email & Phone Number
Structural Biology and Lead Discovery Consultant
at
Brent Appleton Scientific Consulting LLC
1 work email found
@c4therapeutics.com
1 phone found area 650
LinkedIn matched
✓ Verified May 2026
4 data sources
Profile completeness 100%
Current company
Role
Structural Biology and Lead Discovery Consultant
Location
Cambridge, Massachusetts, United States
Who is Brent Appleton? Overview
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Quick answer
Brent Appleton is listed as Structural Biology and Lead Discovery Consultant at Brent Appleton Scientific Consulting LLC, based in Cambridge, Massachusetts, United States. AeroLeads shows a work email signal at c4therapeutics.com, phone signal with area code 650, and a matched LinkedIn profile for Brent Appleton.
Brent Appleton previously worked as Structural Biology and Lead Discovery Consultant at Brent Appleton Consulting and Senior Director at C4 Therapeutics, Inc.. Brent Appleton holds Ph.D., Virology (Division Of Medical Sciences) from Harvard University.
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{first_initial}{last}@c4therapeutics.com
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Profile bio
About Brent Appleton
Passionate structural biologist, biophysicist, "drug hunter", and project leader interested in pushing the boundaries of X-ray crystallography, CryoEM, structure-based drug design, fragment-based screening, proteomics, biochemical assays, and biophysics. * Experienced project leader responsible for early discovery projects focused on hit-finding via high throughput and fragment-based screens; validation by biophysical methods, X-ray crystallography and CryoEM; and prioritization for advancement to lead optimization. * Recognized leader in X-ray crystallography, fragment-based screening, and structure-based drug design across multiple disease areas.* Contributed to multiple candidates that advanced to clinical development, including Encorafenib (approved BRAF inhibitor)* Strong leadership skills highlighted by management of internal 4-8 person departments as well as CROs (FTE and FFS models)* Deep knowledge of multiple target classes including kinases, antibodies, membrane proteins, and "undruggable" proteins. * Experienced manager effective in collaboration across organizations, alignment of priorities, and completion of research goals.
Listed skills include Drug Discovery, Biochemistry, Protein Chemistry, Structural Biology, and 13 others.
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Brent Appleton's current company
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Brent Appleton Scientific Consulting Llc
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8 roles
Brent Appleton work experience
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Structural Biology And Lead Discovery Consultant
Brent Appleton Consulting
Senior Director
Current* Senior Director of Protein Sciences group responsible for structural biology, biochemistry, biophysics, protein production and proteomics* Project leader of ligand discovery efforts for early stage targets with focus on fragment-based screening and chemoproteomics* Develop broad platform of protein-centric techniques including X-ray crystallography.
Jul 2024 - Present
Director Of Biochemistry, Biophysics, And Structural Biology
Sep 2021 - Jul 2024
Principal Scientist
May 2018 - Sep 2021
Group Leader, Crystallography And Associate Manager, Structural Biology
Dart Neuroscience Llc
- Group Leader of crystallography engaged in all stages of the pipeline including construct design, purification, crystallization, and determination of soluble and membrane proteins structures.
- Personally solved multiple co-structures including the de novo solutions of a kinase and a GPCR not currently in the public domain.
- Accountable for crystallization robotics (TTP Mosquito, Rigaku CrystalMation, Formulatrix Rock Imager), synchrotron data acquisition, software, and communication with external contractors.
- Wrote pipeline in Python that integrates multiple stages of structure solution (molecular replacement, ligand fitting, refinement) using various software packages (CCP4, AFITT, and Phenix).
- Established a FBS by X-ray crystallography platform including the assembly of a highly soluble, shape diverse fragment library and execution of screens on two targets, resulting in 45 co-structures.
- Project leader for pre-LO and early discovery programs.
Jun 2014 - Feb 2018
Investigator Ii/Iii
- Established track record in all stages of gene-to-structure pipeline including construct design, protein purification, crystallization, and structure solution as evidenced by 350+ co-structures across oncology.
- Experienced in biophysical techniques including ITC, NMR, and DSF.
- Comprehensive understanding of state-of-the-art crystallization technology including the Mosquito (TTP Labtech), Rock Imager (Formulatrix), FR-E SuperBrightTM (Rigaku), and synchrotron sources.
- Expertise in multiple crystallographic packages including CCP4, Phenix, HKL, Coot, and GlobalPhasing.
Oct 2007 - Apr 2014
Postdoctoral Research Fellow
- Led structure solution and analysis for a kinase drug discovery project.
- Solved antibody complexes of neuropilin, HER2, and VEGF and used structures to rationally design new phage display libraries.
- Determined the crystal structure of coronin by multiwavelength anomalous dispersion.
- Collaborated on multiple gene-to-structure projects resulting in the solution of 60+ crystal and NMR structures, multiple pdb entries, and publications.
Aug 2004 - Sep 2007
2 education records
Brent Appleton education
Ph.D., Virology (Division Of Medical Sciences)
Harvard University
B.S., Biochemistry
University Of California, Davis
FAQ
Frequently asked questions about Brent Appleton
Quick answers generated from the profile data available on this page.
What company does Brent Appleton work for?
Brent Appleton works for Brent Appleton Scientific Consulting LLC.
What is Brent Appleton's role at Brent Appleton Scientific Consulting LLC?
Brent Appleton is listed as Structural Biology and Lead Discovery Consultant at Brent Appleton Scientific Consulting LLC.
What is Brent Appleton's email address?
AeroLeads has found 1 work email signal at @c4therapeutics.com for Brent Appleton at Brent Appleton Scientific Consulting LLC.
What is Brent Appleton's phone number?
AeroLeads has found 1 phone signal(s) with area code 650 for Brent Appleton at Brent Appleton Scientific Consulting LLC.
Where is Brent Appleton based?
Brent Appleton is based in Cambridge, Massachusetts, United States while working with Brent Appleton Scientific Consulting LLC.
What companies has Brent Appleton worked for?
Brent Appleton has worked for Brent Appleton Scientific Consulting Llc, Brent Appleton Consulting, C4 Therapeutics, Inc., Casma Therapeutics, and Dart Neuroscience Llc.
How can I contact Brent Appleton?
You can use AeroLeads to view verified contact signals for Brent Appleton at Brent Appleton Scientific Consulting LLC, including work email, phone, and LinkedIn data when available.
What schools did Brent Appleton attend?
Brent Appleton holds Ph.D., Virology (Division Of Medical Sciences) from Harvard University.
What skills is Brent Appleton known for?
Brent Appleton is listed with skills including Drug Discovery, Biochemistry, Protein Chemistry, Structural Biology, Life Sciences, Protein Purification, Molecular Biology, and Protein Expression.
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