Brett Prigaro Email & Phone Number

East Rutherford, New Jersey, Us

Develop process routes to APIs safely and efficiently. The focus is on process improvement of each step and to find non-chromatography conditions for isolation of each intermediate and final compound. Scale range from vial screens to 100g batches

Aurora, Co, Us

Medicinal chemistry of cancer therapeutics

St. Louis, Mo, Us

Provide tutoring of chemistry and organic chemistry to students.• Conducted one-one one tutoring sessions in-person and via electronic video conferencing.

Castle Rock, Colorado, Us

● Developed stability indicating methods on an Agilent 1290 Infinity II HPLC with a DAD or MSdetector for small molecules, vitamins, proteins, and peptides in various matrices.● Worked with developing sample preparation for analytes in gels, oils, pellets and powders.● A trained GMP chemist under ICH, FDA, and USP guidelines.● Supervised the work of 1 chemist as well as 1 forced degradation chemist.● Created a process for the method development team to ensure robust methods were submitted tothe quality department.● Wrote SOPs, validation methods, quality events, and helped with OOS investigations.

Boulder, Co, Us

Develop SAR for kinase inhibition using various tools coupled with organic synthesis● Engaged in development of novel cancer inhibitors using multi-step organic synthesis with the aidof structural biology and computational chemistry.● Developed and troubleshooted synthetic routes in order to find the most efficient way to targetcompounds.● Collaborated with various team members to determine a sound SAR while probing the pocket forpossible future target compounds.● Demonstrated a team player mentality of working on two projects simultaneously while adoptingother responsibilities to keep the lab running smoothly and maintaining high productivity.

Troy, Michigan, Us

A veteran chemist with over 15 years of laboratory experience helping scientists find their ideal position utilizing the vast Kelly network.

Lead Analytical Scientist for the Organic Section following the Clean Water Act• Trained in derivitization techniques such as halo acetic acid, herbicides, endothall, and glyphosate using an Agilent GC/ECD, LC/DAD, or GC/MS.• Extracted urine samples using solid phase extraction columns for FERN for abrine, ricinine, tetramine, MTP, and OPNA, analyzed on an Agilent 1100 LC/MS/MS AP 4000 triple quad.• Troubleshooted instrumentation when results were not acceptable, including method development and calibration curve production.• Implemented new safety standards and inspections as a Chemical Safety Officer, LEAN practices.• Participated in the writing of grant material, researched necessary content, and communicated progress with supervisors.• Collaborated with laboratory quality control to ensure all EPA regulations were met.• Educated customers on the meaning and implications of results.

Focused on the synthesis of patentable compounds to be used as dopants in liquid crystal displays to enhance the viewer experience.• Managed laboratory space, including all chemicals and equipment necessary to carry out the reactions and generate phase diagrams for final compounds. • Balanced multiple projects simultaneously while remaining flexible with changing priorities.• Contributed to grant edits and submission.

Memphis, Tn, Us

• Led the development of a novel asymmetric route and completed large-scale synthesis of a critical side chain fragment for sharing with group members that was coupled with various core fragments.• Experience analyzing complex organic structures that resulted from asymmetric synthesis to determine stereochemistry using X-Ray crystallography, 1D-, 2D-NMR and polarimetry techniques.• Prepared monthly reports to communicate progress, discuss problems and solutions, and outline future goals with my supervisor and team members.• Aided in monthly laboratory safety inspections, noted concerns, and corrected hazards.• Mentored a master’s level chemist. • Volunteered for reviewing pediatric oncology education student’s research proposals as well as helping with on-campus events.

Fort Collins, Co, Us

• Following a logical approach, worked towards the goal of the total synthesis of debromophycolide requiring a retrosynthetic approach of dissecting the target molecule until starting compounds could be purchased commercially: keep big picture in mind while taking one step at a time • Read literature and shared findings with other scientists to keep projects moving forward• Mentored and supervised the research activity of a full-time undergraduate research student to provide a solid foundation in trouble shooting, working independently and organizing researchinterests and long term goals presented to a senior audience • Collection and process of gathered analytical data to determine side products in order to develop a better understanding of a reaction mechanism and potential trouble shooting• Monitored and coordinated pick-up for removal of laboratory waste

Fort Collins, Co, Us

Worked on the total synthesis of debromophycolide under the direction of Professor John L. Wood

Fort Collins, Co, Us

Fort Collins, Co, Us

Fort Collins, Co, Us

Fort Collins, Co, Us

Teaching assistant for four semesters, undergraduate laboratories

Fort Collins, Co, Us

Engaged in the synthesis of derivatives of Cylindrospermopsin for the purpose for biological studiesDeepened skills in synthesis and purification methods of complex intermediates of a natural product

for Discussion Sessions for "Organic Chemistry I"

Bridgewater, Nj, Us

Hit-to-lead compounds were studied for SAR development of a novel drug for viral infections• Performed multi-step synthesis and purification of small molecules for HIV research; prepped final compounds for submission to the biology department for testing (in-house)• Executed purification methods including hand-packed column chromatography or prep TLC• Utilized 1H-NMR, 13C-NMR, LC/MS for compound characterization• Engaged in development of large scale (kilogram) synthesis of lead compound• Practiced lab safety according to OSHA regulations

Primary focus was on the discovery of novel therapeutically active compounds for Alzheimer’s research• Studied side chain manipulations in order to determine compound potency in cell lines• Monitored reactions by HPLC/MS, TLC and/or 1H-NMR• Purified intermediates via chromatotron or hand-packed column chromatography

Research and Development of metallocenes requiring inert atmosphere• Studied the synthesis of transition metal centered catalysts for the purpose of kilogram scale synthesis to be used in the production of plastics • Involved in multi-step small scale studies of ligands that were used in in-house scale-up of the full catalyst, using Schlenk line techniques• Scaled reaction procedures to 2 kilograms utilizing a 30L reactor, necessitating a safety review of the process as well as procedure modifications• Filtered air sensitive compounds under inert atmosphere; bottled in a dry box for shipment• Final catalysts were purified via crystallization

Research of therapeutically active compounds for the Anti-Inflammation groupMutli-step synthesis of biologically active compounds enroute to in-house biological testingStudied synthetic routes with the goal of increasing efficacy Purified compounds via an automated column system Characterized by 1H-NMR, LC/MS, melting point

New Brunswick, Nj, Us

study energy levels of nucleobases and nucleotides in DNA reactivity for the goal of improved drug design. The structure of nucleic acids and enzymatic catalysts were studied using Gaussian Calculations to establish stable conformational states by comparing neutral to charged intermediates. Scientific Skills and Proficiencies -Chemical Synthesis: On-line research, reaction set-up, purification and characterization of organic synthetic steps for advancement of key intermediatesInstruments and Analytical Methods: NMR spectroscopy (1D, 2D), Gas Chromatography coupled with Mass Spectrometry, IR, column chromatography (hand-packed)Computational Literacy: MS Word, MS Powerpoint, Endnote, Chemdraw, Scifinder Client and On-line search engine, Beilstein Crossfire,

Phd, Chemistry

Bachelor Of Science (B.S.), Chemistry And Environmental Science

Environmental Studies