Elena Brevnova Email & Phone Number

London, Gb

Leading Molecular Biology team working on engineering enzymes and strains for plastic material degradation and recycling applications.

Bedford, Massachusetts, Us

• Leading Strain Development, Automation, Analytical and Operation teams • External communication, BD and technical sales • Overseeing and consulting on over 70 microbial engineering projects• Designed and implemented centralized project information storage and sharing system• Lead company-wide career ladder design and implementation • Initiated and overseeing design of centralized DNA/strain storage and documentation system

Boston, Ma, Us

• Company strategic technical vision and development• Senior program lead and people manager supervising teams of scientists working on engineering organisms to produce various value products

Boston, Ma, Us

• Designed the project plan and was leading for the first year the current biggest Ginkgo project, that resulted in launching first cultured cannabinoid product: THC & CBG infused gummy – Speenach Feelz®. • Was leading a technical team developing pooled COVID test for schools resulting in launching commercial product Concentric by Ginkgo.• Initiated, lead designing, building and implementation of Central Strain Banking • Initiated and lead AI / Machine Learning technology based projects for protein production optimization

Cambridge, Ma, Us

• Built EVELO molecular biology laboratory and team for microbiome engineering.• Developed HTP assays for monitoring interaction of bacteria with mammalian cells• Studied mechanism of bacteria anti-cancer mechanisms and identified key genetic targets for anti-cancer bacteria engineering• Designed genetic tools for engineering anaerobic and aerobic anti-cancer bacteria • Applied directed evolution to develop bacteria strain with several orders of magnitude higher tolerance to bile and acid

Paris La Défense Cedex, Fr

• Built first Total molecular biology laboratory and team in Cambridge MA for lipids production in yeast• Provided leadership for Novogy Strain Development group and technical management of Novogy R&D working on developing renewable fuels and chemicals by yeast genetic engineering • Liaison for Total/Novogy collaboration at Novogy site• Administrative management of Total Gas & Power employees at Novogy site

Lebanon, Nh, Us

• Managed a group of scientists working on protein engineering of saccharolytic enzymes with optimized properties for particular substrates and developing yeast strains used for biofuel production from starch and cellulose containing substrates• Responsible for research program, experimental design, product delivery and reports.• Developed first GMO yeast strain approved in the U.S. by AAFCO regulatory agency for use in corn ethanol industry, launching Mascoma’s first commercial product - TransFerm®.

• Optimized production of human antibodies and other therapeutic proteins in yeast Pichia pastoris. • Designed an O-glycosylation regulation system by adopting bacterial TetR regulation system for conditional expression of Pichia pastoris PMT genes. • Studied and reported on the effect of drug-pump-gene knock-outs on O-glycosylation inhibition by PMT inhibitor in Pichia pastoris strains.• Designed chaperone and fusion-protein libraries as tool for glycoprotein expression optimization in Pichia pastoris. • Studied and optimized N-glycosylation occupancy of heterologously expressed proteins in Pichia pastoris.

San Diego, Ca, Us

• Investigated cellular mechanisms of cell proliferation and apoptosis in mammalian cell lines such as pulmonary vascular smooth muscle cells• Studied pathogenic mechanisms involved in primary pulmonary hypertension (PPH).• Showed that overexpression of human Kv1.5 potassium channel induces apoptosis in pulmonary artery smooth muscle cells.

Stanford, Ca, Us

• Studied structure/function relation of gp130 and human interleukin-6 receptor binding to human interleukin-6 by isothermal titration calorimetry. • Expressed gp130-cytokine hexameric signaling complexes (complex of gp130, viral or human interleukin-6 and human interleukin-6 receptor) in insect cells.• Solved hexameric structure and studied assembly of human interleukin-6/IL-6 alpha-receptor/gp130 complex.

Ph.D., Molecular Biology

B.S./M.S., Radiation Biophysics And Ecology