Elena Brevnova Email and Phone Number
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Innovator, researcher and people leader with an extensive experience in molecular biology, protein production optimization, organism genetic engineering, synthetic biology, AI/ML and many other areas of biological science.MAIN AREAS OF EXPERTISE:• Biotech, Pharma, Foodtech, Cleantech• Molecular & Microbiology• Strain, Protein & Metabolic engineering• AI & Machine Learning• BD, Operations & External communication • Strain & DNA banking systems• Microbiome & Oncobiotics• Structural & Synthetic biology• Immunology• Team, Project & Alliance managementHIGHLIGHTS AND ACHIEVEMENTS:• Initiated and led design and implementation of project information and strain/DNA storage systems for Conagen and Ginkgo. Designed and was leading the biggest (at the time) Ginkgo project, that resulted in launching first cultured cannabinoid product: THC & CBG infused gummy – Speenach Feelz®. During pandemic, was leading technical team developing pooled COVID test for schools resulting in launching commercial product Concentric by Ginkgo. Developed first GMO yeast strain approved in U.S. by AAFCO regulatory agency for use in corn ethanol industry, launching Mascoma’s first commercial product - TransFerm®. Built from scratch molecular biology labs and teams for Evelo and Total.• Inventor on multiple issued patents and patent applications for metabolic engineering to produce pharmaceuticals, biochemicals and biofuels (Ginkgo, Total, Mascoma), methods for protein expression optimization, methods to improve yeast strains for human antibodies production (Merck), providing online research services, and many others.• Finalist, 2003 Cournand and Comroe Young Investigator Prize (American Heart Association), for paper on mechanisms of apoptosis in pulmonary vascular smooth muscle cells. Two papers in Science including the paper on hexameric structure of the human interleukin-6/IL-6 alpha-receptor/gp130 complex, and more than 20 other peer-reviewed journal publications.
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Head Of Molecular BiologyEpoch Biodesign Sep 2024 - PresentLondon, GbLeading Molecular Biology team working on engineering enzymes and strains for plastic material degradation and recycling applications. -
Vp Of Metabolic EngineeringConagen Aug 2022 - Mar 2024Bedford, Massachusetts, Us• Leading Strain Development, Automation, Analytical and Operation teams • External communication, BD and technical sales • Overseeing and consulting on over 70 microbial engineering projects• Designed and implemented centralized project information storage and sharing system• Lead company-wide career ladder design and implementation • Initiated and overseeing design of centralized DNA/strain storage and documentation system -
Senior Director (Principal Organism Engineer)Ginkgo Bioworks, Inc. Dec 2020 - Jul 2022Boston, Ma, Us• Company strategic technical vision and development• Senior program lead and people manager supervising teams of scientists working on engineering organisms to produce various value products -
Program Director, Organism EngineeringGinkgo Bioworks, Inc. Jun 2016 - Dec 2020Boston, Ma, Us• Designed the project plan and was leading for the first year the current biggest Ginkgo project, that resulted in launching first cultured cannabinoid product: THC & CBG infused gummy – Speenach Feelz®. • Was leading a technical team developing pooled COVID test for schools resulting in launching commercial product Concentric by Ginkgo.• Initiated, lead designing, building and implementation of Central Strain Banking • Initiated and lead AI / Machine Learning technology based projects for protein production optimization -
Director Strain EngineeringEvelo Therapeutics Jun 2015 - Jun 2016Cambridge, Ma, Us• Built EVELO molecular biology laboratory and team for microbiome engineering.• Developed HTP assays for monitoring interaction of bacteria with mammalian cells• Studied mechanism of bacteria anti-cancer mechanisms and identified key genetic targets for anti-cancer bacteria engineering• Designed genetic tools for engineering anaerobic and aerobic anti-cancer bacteria • Applied directed evolution to develop bacteria strain with several orders of magnitude higher tolerance to bile and acid -
Scientific Program Manager (Total) - Director Strain Development (Novogy)Total New Energies (Novogy) May 2012 - Jun 2015Paris La Défense Cedex, Fr• Built first Total molecular biology laboratory and team in Cambridge MA for lipids production in yeast• Provided leadership for Novogy Strain Development group and technical management of Novogy R&D working on developing renewable fuels and chemicals by yeast genetic engineering • Liaison for Total/Novogy collaboration at Novogy site• Administrative management of Total Gas & Power employees at Novogy site -
Senior Scientist/Project LeaderMascoma Corp. Sep 2007 - May 2012Lebanon, Nh, Us• Managed a group of scientists working on protein engineering of saccharolytic enzymes with optimized properties for particular substrates and developing yeast strains used for biofuel production from starch and cellulose containing substrates• Responsible for research program, experimental design, product delivery and reports.• Developed first GMO yeast strain approved in the U.S. by AAFCO regulatory agency for use in corn ethanol industry, launching Mascoma’s first commercial product - TransFerm®. -
Research ScientistMerck (Glycofi) Mar 2004 - Aug 2007• Optimized production of human antibodies and other therapeutic proteins in yeast Pichia pastoris. • Designed an O-glycosylation regulation system by adopting bacterial TetR regulation system for conditional expression of Pichia pastoris PMT genes. • Studied and reported on the effect of drug-pump-gene knock-outs on O-glycosylation inhibition by PMT inhibitor in Pichia pastoris strains.• Designed chaperone and fusion-protein libraries as tool for glycoprotein expression optimization in Pichia pastoris. • Studied and optimized N-glycosylation occupancy of heterologously expressed proteins in Pichia pastoris.
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Postgraduate Research ScientistUniversity Of Ca, San Diego Apr 2002 - Mar 2004San Diego, Ca, Us• Investigated cellular mechanisms of cell proliferation and apoptosis in mammalian cell lines such as pulmonary vascular smooth muscle cells• Studied pathogenic mechanisms involved in primary pulmonary hypertension (PPH).• Showed that overexpression of human Kv1.5 potassium channel induces apoptosis in pulmonary artery smooth muscle cells. -
Postdoctoral FellowStanford University School Of Medicine Aug 2000 - Mar 2002Stanford, Ca, Us• Studied structure/function relation of gp130 and human interleukin-6 receptor binding to human interleukin-6 by isothermal titration calorimetry. • Expressed gp130-cytokine hexameric signaling complexes (complex of gp130, viral or human interleukin-6 and human interleukin-6 receptor) in insect cells.• Solved hexameric structure and studied assembly of human interleukin-6/IL-6 alpha-receptor/gp130 complex.
Elena Brevnova Skills
Elena Brevnova Education Details
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GosniigenetikaMolecular Biology -
National Research Nuclear University Mephi (Moscow Engineering Physics Institute)Radiation Biophysics And Ecology
Frequently Asked Questions about Elena Brevnova
What company does Elena Brevnova work for?
Elena Brevnova works for Epoch Biodesign
What is Elena Brevnova's role at the current company?
Elena Brevnova's current role is Biotech leader with experience in microbial engineering and AI.
What is Elena Brevnova's email address?
Elena Brevnova's email address is el****@****rks.com
What is Elena Brevnova's direct phone number?
Elena Brevnova's direct phone number is (877) 422*****
What schools did Elena Brevnova attend?
Elena Brevnova attended Gosniigenetika, National Research Nuclear University Mephi (Moscow Engineering Physics Institute).
What are some of Elena Brevnova's interests?
Elena Brevnova has interest in Children, Civil Rights And Social Action, Education, Science And Technology, Human Rights, Animal Welfare, Arts And Culture.
What skills is Elena Brevnova known for?
Elena Brevnova has skills like Molecular Biology, Biotechnology, Protein Chemistry, Biochemistry, Biofuels, R&d, Protein Expression, Genetics, Protein Purification, Cell Biology, Pcr, Microbiology.
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