Brian Granger Email & Phone Number

South San Francisco, California, Us

Act as a liaison between Twist and their customers to help them understand how Twist's NGS products can help them overcome their scientific and technical challenges. Responsible for pre-and post-sales support and market development activities for Twist's NGS target enrichment portfolio.

Boston, Massachusetts, Us

• Used probe/variant alignment (BWA) and visualization (IGV) to detect and troubleshoot poorly constructed probes, allowing chip optimization.• Maintained storage and improved accuracy of probe and variant information in a database.• Streamlined process for manual results review, resulting in significant reduction of valueless set-up time. • Provided interpretation of results, including analytical quality control support.

• Onboarded, validated, and improved various NGS pipelines. Incorporated each pipeline into a cloud pipeline environment called Terra, built on GCP, allowing processing of high throughput genomic data en masse; pipelines included: ◦ Single-cell RNA-Seq ◦ SNP/Indel calling ◦ CNV calling ◦ SV calling ◦ Microbiome classification and quantification• Processed sequencing data, including Illumina-generated, clinical CLIA / CAP data, through pipelines in the cloud, in an analysis-as-a-service setting, using CI/CD practices to provide bioinformatics support to both internal/external collaborators (academic/biotech/pharma). • Provided expert guidance on product recommendations; communicated closely with internal team members, project and product managers, and collaborators. • Trained 3 team members, including 1 direct report, as well as 2 non-permanent rotating students in processing data through computational pipelines, returning results to collaborators, and tools for work management.

Cambridge, Cambridgeshire, Gb

• Augmented RNA-seq data with genomic allele frequency (AF) data to determine how AF variations affect drug treatment of tumors, and elucidate novel splicing mechanisms.• Detected variants with AF that differ significantly between the genome and the transcriptome, which could indicate different expression of alleles or RNA editing, leading to alternative drug treatments.

Boston, Ma, Us

Constructed and annotated cnidarian transcriptomes, made available on a publicly accessible website to empower cnidarian researchers. Additionally, built upon my interest of the symbiotic aspect of these organisms by studying the metabolic exchange of microbes in various environments in silico, eventually transitioning from well studied and documented organisms to those likely to be found residing in the coral microbiome.

Pittsburgh, Pa, Us

Determined three dimensional protein localization in human colon cancer cells using fluorescent antibody tags and confocal fluorescence microscopy to produce an image database to train a random forest algorithm to recognize spatial patterns.

Planned activities and classes to teach children about nature, and cared for the animals involved in the program.

Doctor Of Philosophy (Ph.D.), Bioinformatics

Bs, Computational Biology