Brian Goetz Email & Phone Number

St. Louis, Mo, Us

United States

United States

The Tissue Procurement Core (TPC) is a College of American Pathologist (CAP) accredited biorepository that provides Washington University Physician/Scientists with a centralized resource to collect, process, store and utilize human biospecimens for translational biomedical research. The TPC aims to provide a general archive of annotated frozen tumor and patient-matched non-malignant tissues for pilot, retrospective correlative science studies, assist investigators in the prospective collection and storage of biospecimens from participants enrolled on specific clinical studies, and facilitate the use of human biospecimens and their derivatives for molecular and genomic research. Dedicated staff and facilities are used to generate bio-fluid derivatives (serum, plasma, cell isolates), nucleic acid (DNA and RNA) and histological derivatives (embedding/sectioning) from patient-derived specimens. Services to facilitate tissue-based translational research such as laser capture microdissection, along with pathology consultation resources, are also available. An archive of snap-frozen biospecimens (tumor tissue, non-malignant tissue, serum, plasma) and corresponding de-identified pathology and demographic data from patients with a variety of solid and hematologic malignancies are also available for IRB-approved investigator studies through the TPC General Specimen Bank Registry. Currently, the tissue bank contains more than 700,000 specimens and greater than 95% of the banked tissue is in support of life science and biomedical research. https://siteman.wustl.edu/

Washington University School Of Medicine, Department Of Surgery

Manager of the Solid Tumor Tissue Bank & Registry within the Section of Hepatobilliary Surgery. Our mission is to facilitate access to annotated clinical specimens and develop in vitro and in vivo tools to enable greater scientific understanding, and clinical management, of gastrointestinal solid tumor disease. We currently support genetic, epigenetic, metabolomic, transcriptomic and immunological approaches for studying several gastrointestinal cancers including colorectal, pancreatic and neuroendocrine cancer.

Translational Pharmacologist using in vitro, in vivo and ex vivo systems to identify alternate indications for early-to-late stage drug candidates in the areas of cardiovascular disease, dyslipidemia, obesity, diabetes, oncology, infectious disease and neurological disorders.http://www.pfizer.com

Translational Pharmacologist executing in vitro, ex vivo and in vivo studies to identify novel pharmaceuticals (Small molecules and Biologics) aimed at treating and preventing the metabolic syndrome and cardiovascular disease.http://www.esperion.com/

My work focused on identifying the genetic and cellular events involved in mammalian central nervous system (CNS) myelination and demyelination. In addition, I worked on a number of research projects aimed at deciphering the role of reactive microglia in models of CNS dysmyelination and demyelination with an emphasis on understanding the impact this inflammatory cell population had on viability of transplanted myelinating cells. http://www.vetmed.wisc.edu/dms/duncan/index.html