Brian Rabkin Email & Phone Number

California, United States

Chicago, IL, US

Part of the Enterprise Peak engineering advisory practice focused on running R&D engagements in the Medical Device and Life Sciences sectors. Programs include combination of software, hardware, clinical assays as well as the overall architecture of complex systems.

• Provided technical expertise in molecular biology assay development, NGS, instrumentation, and bioinformatics to consulting organization and clients.
• Developed assays, algorithms, machine learning models, instrumentation, cloud pipelines, and data visualization in life sciences.
• Collaborated with cross-functional teams to drive innovation and deliver high-quality solutions in biotechnology consulting.

Indianapolis, Indiana, US

Directed cross-functional algorithm and data science teams to develop AI/ML models predicting diagnostic assay outcomes during new product development, enhancing accuracy and decision-making.* Spearheaded a cloud-based pipeline for data engineering, inference, analysis, and visualization, reducing manual workflows and improving data accessibility.* Served.

San Carlos, California, US

Indianapolis, Indiana, US

Indianapolis, Indiana, US

• Direct research and development planning, characterization and integration efforts for developing a novel IVD Nanopore DNA Sequencer.
• Coordinate a cross-disciplinary team and balance the efforts of Research and Development to deliver a sequencing platform that meets the performance and quality targets defined for the IVD product.
• Lead the planning, evaluation and characterization of the chemistry, nanopores, hardware, software, bioinformatics, fluidics, and other aspects of the prototype platform.
• Oversee internal and consultant experts in biology, chemistry, hardware, software, bioinformatics, fluidics, and mechanical engineering to specify and produce a prototype platform.

Emeryville, CA, US

• Led a diverse team of experts towards a commercially viable Searchlight Cellular Therapy Manufacturing Platform that can be deployed at point of care or at a centralized facility.
• Worked directly with external collaborators to translate and optimized ETC, TIL and CAR-T/TCR immunotherapy workflows into commercially viable products.
• Led a team developing integrated fully disposable micro- and macro-fluidic consumables for performing end-to-end immunotherapy workflows that are GMP compliant without the need for a GMP facility.
• Developed single cell genomics applications implementing aqueous-in-oil sample preparation methodologies.
• Originated the concepts and proved feasibility of two novel FACS devices, and filed for multiple patents.
• Implemented electronic laboratory notebook system using Confluence and AGILE SCRUM methodologies to improve the integration of the engineering and biology teams to accelerating the rate of development.

Emeryville, CA, US

• Led a diverse team of experts towards a commercially viable Searchlight Cellular Therapy Manufacturing Platform that can be deployed at point of care or at a centralized facility.
• Worked directly with external collaborators to translate and optimized ETC, TIL and CAR-T/TCR immunotherapy workflows into commercially viable products.
• Led a team developing integrated fully disposable micro- and macro-fluidic consumables for performing end-to-end immunotherapy workflows that are GMP compliant without the need for a GMP facility.
• Developed single cell genomics applications implementing aqueous-in-oil sample preparation methodologies.
• Originated the concepts and proved feasibility of two novel FACS devices, and filed for multiple patents.
• Implemented electronic laboratory notebook system using Confluence and AGILE SCRUM methodologies to improve the integration of the engineering and biology teams to accelerating the rate of development.

Dallas, Texas, US

• Led an effort to develop the high-throughput single-cell analysis program at Verily to elucidate the cellular heterogeneity in human health for therapeutic discovery and monitoring of disease.
• Evaluated and developed methods and platforms for the enrichment, isolation, genomic and transcriptional analysis of immune and cancer cells from liquid or solid biopsies, including circulating tumor cells (CTCs).
• Studied the ability of single-cell analysis techniques to differentiate between closely related T cell subtypes at the phenotypic, functional and receptor specificity level.
• Contributed to the early phase development of microfluidics systems for cell isolation and reverse transcription (RNAseq) through sequencing library preparation, including droplet-based systems.
• Co-invented and filed for three patents on micro-FACS and light sheet imaging cytometry.

San Diego, CA, US

• Contributed to the early phase development of multiple sequencing platforms, including the development and implementation of hardware, chemistry and software for single molecule sequencing and fully integrated.
• Served as Project Core Team integration lead for the Illumina MiSeqDx Cystic Fibrosis program.
• Developed custom prototype instruments for sequencing and sample preparation. Including optics, mechanics, sensors, digital and micro-fluidics, control and analysis software, and on instrument chemistry.
• Developed computational methods for signal processing from custom CMOS imagers and single-cell sorters.
• Developed bioinformatics programs for data aggregation and visualization to determine the underlying causes (hardware, software and chemistry) of errors in sequencing data.

San Diego, CA, US

• Contributed to the development of multiple Illumina sequencing platforms (GA, GAII, GAIIX, HiSeq, MiSeq), including the design, implementation and evaluation of hardware, chemistry and software.
• Served as Project Core Team integration lead for TruSeq Amplicon targeted sequencing sample preparation kit, a sequencing platform and a diagnostic product.
• Part of the select Peer Technical Review team to aid senior management in assessing major development projects.
• Managed and directed members of the systems integration team and development project sub-teams during the development phases (concept – breadboard – production).

San Diego, CA, US

• Contributed to the development of multiple Illumina sequencing platforms (GA, GAII, GAIIX, HiSeq, MiSeq), including the design, implementation and evaluation of hardware, chemistry and software.
• Served as Project Core Team integration lead for TruSeq Amplicon targeted sequencing sample preparation kit, a sequencing platform and a diagnostic product.
• Served on Peer Technical Review panels for many major development projects.
• Managed and directed members of the systems integration team and project sub-teams during the development phases (concept – breadboard – production).

Berkeley, California, US

Genomic Technologies Program * Led the development of methods that combine fluorescence activated cell sorting (FACS) and DNA sequencing for the metagenomic analysis of naturally occurring and engineered microbial communities with the aim of improving biofuel production and pollution control through bioremediation. * Developed high-throughput multiplexed.

Seattle, WA, US

* Engineered and evaluated non- and minimally-invasive ultrasound surgical and imaging devices for the treatment of ovarian cancer and cessation of bleeding.* Developed a Color-Doppler ultrasound imaging method for the real-time guidance and monitoring of high intensity focused ultrasound (HIFU) surgery.* Researched the physiological and morphological.

Seattle, WA, US

* Developed a novel protein separation and analysis instrument for the isoelectric fractionation (IEF) of proteins in free solution for proteomic applications.* Built a custom capillary isoelectric focusing (CIEF) instrument for protein separation and quantification.

* Sequenced the first draft of the human genome.* Mapped and sequenced a portion of the Human Chromosome 4.* Developed bioinformatics software for tracking experiments and samples and for the analysis of data using Perl CGI scripts implemented through dynamic web pages and UNIX.* Developed a cultured bacteria library for tracking human artificial clones.

Washington, DC, US

* Researched the effects of loading, hyper-loading and unloading on bone mineralization in-vivo in rats.* Designed an in-vivo strain gauge telemetry system for studying the affects of age on bone remodeling in rats.* Studied the in-vitro remodeling of bone specimens by cultured osteoblasts and osteoclasts.

Ph.D., Bioengineering

M.S., Bioengineering

B.A., Marine/Aquatic Biology