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Brian Hamman Email & Phone Number

Executive Director, Lead Discovery and Chemical Biology at HotSpot Therapeutics, Inc.
Location: Boston, Massachusetts, United States 8 work roles 4 schools
1 work email found @hotspotthera.com 1 phone found area 858 LinkedIn matched
✓ Verified May 2026 4 data sources Profile completeness 100%

Contact Signals · 1 work email · 1 phone

Work email b****@hotspotthera.com
Direct phone (858) ***-****
LinkedIn Profile matched
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Current company
HotSpot Therapeutics, Inc.
Role
Executive Director, Lead Discovery and Chemical Biology
Location
Boston, Massachusetts, United States
Company size
62 employees

Who is Brian Hamman? Overview

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Quick answer

Brian Hamman is listed as Executive Director, Lead Discovery and Chemical Biology at HotSpot Therapeutics, Inc., a company with 62 employees, based in Boston, Massachusetts, United States. AeroLeads shows a work email signal at hotspotthera.com, phone signal with area code 858, and a matched LinkedIn profile for Brian Hamman.

Brian Hamman previously worked as Executive Director, Chemical Biology at Hotspot Therapeutics, Inc. and Director of Biophysics and in vitro Biology at Wuxi Apptec. Brian Hamman holds Post-Doctoral Research, Medical Biochemistry Dept. from Texas A&M University.

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Email format at HotSpot Therapeutics, Inc.

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{first_initial}{last}@hotspotthera.com
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Profile bio

About Brian Hamman

Over twenty-six years of innovation in the biotechnology and drug discovery industries. Extensive knowledge and proven success in all aspects of preclinical small-molecule drug discovery. Expertise includes target identification and validation, cutting edge biochemical and cell-based assay development, all types of high-throughput screening and chemical libraries, custom made counter and secondary assays, exceptional expertise and emphasis on biophysics, deep understanding and extensive knowledge on PROTACs plus other branches of induced proximity. Proven success on elucidating mechanism of drug action, chemical biology and proteomics, biomarkers, and in vivo pharmacology on a very wide range of disease models. Exceptionally diverse expertise with regards to target classes and assay technologies. Strong track record of leading multi-disciplinary drug discovery teams in the identification of novel clinical candidates leading to human clinical trials in a very wide range of human diseases. Highly collaborative with excellent written and verbal communication skills.

Listed skills include Drug Discovery, Assay Development, Biochemistry, Biotechnology, and 46 others.

Current workplace

Brian Hamman's current company

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HotSpot Therapeutics, Inc.
Hotspot Therapeutics, Inc.
Executive Director, Lead Discovery and Chemical Biology
Boston, MA, US
Website
hotspotthera.com
Employees
62
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8 roles · 22 years

Brian Hamman work experience

A career timeline built from the work history available for this profile.

Director Of Biophysics And In Vitro Biology

Wuxi Apptec

Shanghai, Shanghai, CN

  • Created and led a new Biophysics department with rapid increase in clients, revenue, personnel, lab space, and instrumentation (especially SPR, LCMS, ASMS, MST, TSA).
  • As co-Director of the in vitro Biology site in New Jersey, oversaw early stage drug discovery projects for about 25 clients, including biochemical and cell-based assay development, HTS, and Lead Optimization assay.
  • Multiple awards from WuXi and clients.
Aug 2019 - Nov 2020

Director, Biophysics

Arvinas

New Haven, Connecticut, US

  • Rapidly built and led all biochemistry and biophysics capabilities for Arvinas. My group also developed a wide range of cell-based assays for many internal and external drug discovery projects.
  • Designed and executed some of the key early discoveries on the revolutionary PROTAC technology, some of which are disclosed in multiple publications in top tier journals.
  • Successfully led and co-led multiple internal and external drug discovery projects based on PROTACs.
  • Arvinas biology lead for the highly successful collaboration with Genentech, resulting in a major expansion of our business deal and collaboration.
2015 - 2019 ~4 yrs

Associate Director, Pharmaceutical Discovery

Lexicon Pharmaceuticals

The Woodlands, TX, US

  • Program Leader for a highly novel drug discovery program resulting in clinical candidates for Neuropathic Pain. Led multi-disciplinary team from target validation to biochemical and cell-based assay support, HTS.
  • Co-leader of two novel drug discovery programs for Immunology. From assay dev to HTS, H2L, thru LO and up to clinical candidacy.
  • Managed medicinal chemistry assay support for six different drug discovery programs.
  • Co-led the Lexicon/BMS Neuroscience alliance for a drug discovery program that won the 2011 BMS DWG Innovation Award.
  • Led assay development and high-throughput screening for six different targets.
  • Authored/Co-authored eight publications and co-wrote several patent applications.
2010 - 2015 ~5 yrs

Sr. Scientific Group Leader

Lexicon Pharmaceuticals

The Woodlands, TX, US

  • Started off as Senior Scientist in March 2004. Promoted to Sr. Scientific Group Leader in March 2006 and to Associate Director in March 2010.
  • Led one drug discovery program and co-led several others, resulting in three clinical candidates (cancer, glaucoma, and an immunological disease).
  • Led assay development and high-throughput screening for about 20 different targets.
  • Managed medicinal chemistry assay support for four different drug discovery programs.
  • Co-led Lexicon/BMS alliance for drug discovery in neuroscience.
  • Co-authored multiple publications and patent applications.
2004 - 2010 ~6 yrs

Principal Scientist

Vertex Pharmaceuticals

Boston, MA, US

  • Aurora Biosciences acquired by Vertex in May 2001. While at Vertex, here is some of what I did:Fluorescence-based assay development and uHTS for small-molecule drug discovery. Expertise in biochemical and biophysical.
  • Successfully managed seven collaborative assay and/or screen development projects. Included writing of work plans, experimental design, executing and troubleshooting experiments, managing scientists and large amounts.
  • Led in vitro assay support for fifteen early stage internal drug discovery projects, including a variety of targets and assays (for neuroscience, anti-infectives, cancer). Responsibilities similar to that described in.
  • First/senior author of one manuscript, a patent application, and several invention disclosures. Major contributor to many other projects and invention disclosures.
May 2001 - May 2004

Senior Scientist/Principal Scientist

Aurora Biosciences Corporation
  • The late great, Roger Tsien, is the scientific founder of this company that quickly became profitable. The platform involved novel fluorescence-based assay development for both Aurora and several big pharma companies.
  • Managed and executed multiple collaborative screening projects (cancer and Alzheimer's; several big pharma companies) involving novel spectroscopic-based assay technologies. Responsibilities including everything from.
  • Primary inventor in high impact patent and wrote first manuscript regarding a novel FRET-based method for assaying most kinases and phosphatases (Z’-Lyte assay technology currently marketed by Thermo Fisher). Co-author.
  • Principal investigator on top ranked NIH/SBIR grant regarding a novel cell-based assay technology.
Apr 1998 - May 2001
Team & coworkers

Colleagues at HotSpot Therapeutics, Inc.

Other employees you can reach at hotspotthera.com. View company contacts for 62 employees →

JD Jovan Dragelj Jovan Dragelj Colleague at Hotspot Therapeutics, Inc.Berlin, Berlin, Germany, Germany View → YQ Yilin Qi Yilin Qi Colleague at Hotspot Therapeutics, Inc.Greater Boston, United States View → KE Katherine Eyring, Pace Katherine Eyring, Pace Colleague at Hotspot Therapeutics, Inc.Greater Boston, United States View → PT Paul Thibodeau Paul Thibodeau Colleague at Hotspot Therapeutics, Inc.Lexington, Massachusetts, United States, United States View → SS Srilatha Simhadri Srilatha Simhadri Colleague at Hotspot Therapeutics, Inc.Princeton Junction, New Jersey, United States, United States View → KS Kathleen Smith Kathleen Smith Colleague at Hotspot Therapeutics, Inc.Cambridge, Massachusetts, United States, United States View → LM Lisa Marie Simon Lisa Marie Simon Colleague at Hotspot Therapeutics, Inc.Berlin, Berlin, Germany, Germany View → GM Ghouse Mohideen Ghouse Mohideen Colleague at Hotspot Therapeutics, Inc.Chennai, Tamil Nadu, India, India View → KL Kevin Ling Kevin Ling Colleague at Hotspot Therapeutics, Inc.Greater Boston, United States View → YB Yingzhi Bi Yingzhi Bi Colleague at Hotspot Therapeutics, Inc.Princeton, New Jersey, United States, United States View →
4 education records

Brian Hamman education

Post-Doctoral Research, Medical Biochemistry Dept.

Texas A&M University

Phd, Biochemistry And Biophysics

University Of Hawaii John A. Burns School Of Medicine

Bachelor Of Science (B.S.), Major: Biomedical Sciences; Minor: Chemistry

Western Michigan University

High School Diploma

Parchment High School
FAQ

Frequently asked questions about Brian Hamman

Quick answers generated from the profile data available on this page.

What company does Brian Hamman work for?

Brian Hamman works for HotSpot Therapeutics, Inc..

What is Brian Hamman's role at HotSpot Therapeutics, Inc.?

Brian Hamman is listed as Executive Director, Lead Discovery and Chemical Biology at HotSpot Therapeutics, Inc..

What is Brian Hamman's email address?

AeroLeads has found 1 work email signal at @hotspotthera.com for Brian Hamman at HotSpot Therapeutics, Inc..

What is Brian Hamman's phone number?

AeroLeads has found 1 phone signal(s) with area code 858 for Brian Hamman at HotSpot Therapeutics, Inc..

Where is Brian Hamman based?

Brian Hamman is based in Boston, Massachusetts, United States while working with HotSpot Therapeutics, Inc..

What companies has Brian Hamman worked for?

Brian Hamman has worked for Hotspot Therapeutics, Inc., Wuxi Apptec, Arvinas, Lexicon Pharmaceuticals, and Vertex Pharmaceuticals.

Who are Brian Hamman's colleagues at HotSpot Therapeutics, Inc.?

Brian Hamman's colleagues at HotSpot Therapeutics, Inc. include Jovan Dragelj, Yilin Qi, Katherine Eyring, Pace, Paul Thibodeau, and Srilatha Simhadri.

How can I contact Brian Hamman?

You can use AeroLeads to view verified contact signals for Brian Hamman at HotSpot Therapeutics, Inc., including work email, phone, and LinkedIn data when available.

What schools did Brian Hamman attend?

Brian Hamman holds Post-Doctoral Research, Medical Biochemistry Dept. from Texas A&M University.

What skills is Brian Hamman known for?

Brian Hamman is listed with skills including Drug Discovery, Assay Development, Biochemistry, Biotechnology, Protein Chemistry, High Throughput Screening, Pharmacology, and Cell.

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