Brian Whiteley Email & Phone Number

New Jersey

Provide Pre-Sales technical and application assistance in response to inquires for Agilent's HPLC portfolio. Conduct on-site or in-house demonstrations to highlight LC products. Prepare and present technical seminars to customers, potential customers and field sales teams. Emphasis on applications relating to pharmaceuticals, cannabis potency applications, and prep LC.

Lawrencville, Nj

Design, synthesis, and purification of small molecules in support of immunology projects.

Lawrenceville, New Jersey

Design, synthesis, and optimization of peptide macrocycles to improve stability and bioavailability.

Medicinal ChemistryDesign, synthesis, and purification of targeted small molecule libraries of 500 members geared towards disrupting protein-protein interactions.

High Throughput Medicinal ChemistryPreparation of small molecule libraries in support of Therapeutic Strategic Units. Designed and prepared hit/lead libraries for project teams to guide SAR. Evaluation of new equipment and techniques for synthesis and purification. Evaluated and recommended purchase of Waters Prep LC/MS purification system to upper management to reduce bottleneck in the purification of small molecule libraries prepared by HTMC. Prepared 3 (40 member)… Show more High Throughput Medicinal ChemistryPreparation of small molecule libraries in support of Therapeutic Strategic Units. Designed and prepared hit/lead libraries for project teams to guide SAR. Evaluation of new equipment and techniques for synthesis and purification. Evaluated and recommended purchase of Waters Prep LC/MS purification system to upper management to reduce bottleneck in the purification of small molecule libraries prepared by HTMC. Prepared 3 (40 member) focused libraries in support of Ageing TSU in collaboration with Molecular Modeling utilizing Mettler Toledo MiniBlock XT system. Show less

CNS Therapeutic DepartmentPlanning, synthesis, and purification of small molecules in support of CNS Projects. Collaborate with team members in the design and synthesis of new targets to help guide SAR towards a development candidate. Prepared a library of 25 key indole compounds to expand SAR of lead compound for kinase project. Worked with Chemical Development in preparing multigram quantities of key intermediates towards final target for in-vivo testing. Received… Show more CNS Therapeutic DepartmentPlanning, synthesis, and purification of small molecules in support of CNS Projects. Collaborate with team members in the design and synthesis of new targets to help guide SAR towards a development candidate. Prepared a library of 25 key indole compounds to expand SAR of lead compound for kinase project. Worked with Chemical Development in preparing multigram quantities of key intermediates towards final target for in-vivo testing. Received Sanofi-Aventis Special Achievement award for work as Chemical Safety Officer(2007). Evaluated and recommended purchase of Agilent 1200 LC/MS to management. System was incorporated into medicinal chemistry labs and increased workflow of analytical samples in the department. Oversaw installation, and worked with vendor and analytical group on method development. Mentored summer intern in the design and preparation of azaindole library in support of kinase project. Show less

HTMC/Internal Medicine TDPlanning, synthesis, and purification of small molecules/libraries in support of medicinal chemistry.Designed and optimized synthesis that improved solubility of lead compound for rheumatoid arthritis kinase project. Prepared sets of diverse amide libraries that resulted in the lead compound for serine protease project.

Automated Synthesis and New Technologies/HTMCEvaluation, optimization and preparation of small molecule libraries on solid support utilizing IRORI technology. Evaluation and assessment of solid phase hardware/software/techniques. Given special project to prepare 3000 member library utilizing simultaneous release and functionalization from solid phase, optimized reactions over 3 months, utilized to prove usefulness of IRORI technology. Resulted in receiving the Hoechst Marion… Show more Automated Synthesis and New Technologies/HTMCEvaluation, optimization and preparation of small molecule libraries on solid support utilizing IRORI technology. Evaluation and assessment of solid phase hardware/software/techniques. Given special project to prepare 3000 member library utilizing simultaneous release and functionalization from solid phase, optimized reactions over 3 months, utilized to prove usefulness of IRORI technology. Resulted in receiving the Hoechst Marion Roussel Achievement Award for Automated Synthesis &New Technologies, Library Synthesis (1999).Requested by senior management to evaluate prep LC purchase. Surveyed possible vendors and created presentation with recommendation to senior management within four months. Recommendation was accepted. Coordinated installation, prepared methods and trained users. This equipment increased turnaround in compound purification. Participated in Chromatography Sub Team which identified several key normal phase LC instruments that were employed throughout medicinal chemistry and which has led to improved turnaround in compound purification. Show less

Preparation of small molecule libraries on solid support. Evaluation and optimization of reactions on solid phase. Preparation of libraries through automated and combinatorial techniques for use in High Throughput Screening.

Prepared novel, small molecule encoded libraries on solid support. Evaluated solution phase chemistry and its application towards solid phase synthesis. Prepared quality control samples and encoded combinatorial libraries.

Preparation, purification, and structural characterization of novel ion channel blocking compounds through traditional multistep synthesis and combinatorial techniques. Maintaining chemical compound database and tracking assay results, Preparation of combinatorial libraries for biological assays, Chemical reagent ordering and inventory, Stocking laboratory equipment, Maintaining Bruker ARX NMR system (software, magnet, and air compressor), Hazardous waste management.

Solid FormulationsPreparation of Solid Dosage forms for OTC Pharmaceuticals. Improving solid dosage formulations for manufacturing, Stability testing.

Identify chemical reactivity, hazard and classification for packaging and disposal. Maintaining Corporate Chemical Database, Assigning DOT, EPA, and State Hazard Codes, Interpretation of CFR Regulations and their application to AETC business, Maintaining Reactive Chemical Database (Organic Peroxides, Azo Compounds, Peroxide Formers and Explosives), Reactive Chemical Lab Pack field work, Safety plans.

Bs, Chemistry

Activities and Societies: ACS, AIChE Member Varsity Lacrosse Team 1989 Lacrosse Team MVP

Education record

“Overview of Organic Fluorine Chemistry” Professor William R Dolbier Jr, Nov. 2009 “The Art of Writing Reasonable Organic Reaction.