Brian Roesch Email & Phone Number

Wilmington, De, Us

Wilmington, De, Us

Philadelphia , Pennsylvania, Us

Process Research & Development to discover, develop, scale up and commercialize technology to manufacture new pesticides.

Brentford, Middlesex, Gb

• Developed, scaled up and commercialliized a continuous distillation process using a thin film evaporator to remove solvent and concentrate an Advanced Pharmaceutical Intermediate (API) in a flow (continuous) process to manufacture Daprodustat (to treat anemia associated with chronic kidney disease). Discovered for this separation that the primary scaleup & control parameter was Distillate-to-Feed Ratio. IMPACT: This single parameter enabled the trade-off between API quality and robust performance in the subsequent crystallization to be achieved over a wide range of pressure.• Developed a lab-scale flow process to manufacture a key amino alcohol intermediate for the production of a PRMT5 inhibitor (in a class of oncology targets). The new continuous process addressed manufacturability issues present in the batch process, such as elimination of the isolation of an unstable intermediate, reducing reaction time, and reducing inventory of hazardous reagents. Using high efficiency flow reactors to telescope 2 steps during continuous operation, operating conditions were found where the fast hydrolysis reaction was not mass transfer limited which reduced formation of impurities & increased reaction rate. The effect of residence time and temperature on conversion was mapped out and used to recommend a reactor design and conditions for larger scale operation.• Evaluated effect of mixing on mass transfer and kinetics in several Pd-catalyzed carbonylation & hydrogenation reactions. Scaled up mixing conditions to avoid mass transfer limitations in a hydrogenation step for commercial production Balantamab Mafadotin (antibody-drug conjugate for multiple myeloma).

Wilmington, De, Us

Process research & development chemical engineer experienced at developing & scaling up traditional chemical processes and biochemical processes from concept to commercialization.- As a bioprocess engineer, developed new extractive fermentation technology that removes the product away from the microorganism as it's generated to overcome tolerance issues. Part of that technology (removal of solids & corn oil before fermentation), which is required for the extraction to be feasible, was retrofitted into an existing ethanol plant and commercialized in 2013. Implementing the front end of new technology developed for a new biofuel into an existing ethanol plant resulted in the generation of a new coproduct for that plant (high quality corn oil at high yields). The coproduct corn oil generates $5 MM/yr, and there was only a 2 year pay-back on the CapEx.- As a bioprocess engineer, developed and optimized an enzyme catalyzed reaction to convert starch & simple sugars to useful chemicals with using design of experiments. Technoeconomic analysis was done to evaluate the tradeoff between enzyme cost (OpEx) and reactor cost (CapEx). The results of this analysis enabled the optimum reaction time to be found. Scaled up the reaction from 200 mL to 3000 L at a pilot plant in Finland. Reaction rate, yields, and product composition at large scale were similar to lab scale.- When in Crop Protection R&D, developed new hydrogenation technology that reduced catalyst loss by 5X in a process to make an intermediate for a new insecticide. The new hydrogenation was implemented in the first commercial campaign to make the intermediate in China, 2008

Midland, Michigan, Us

Dow (2001-2005)/Union Carbide (1994-2000): Process research & development engineer. Experienced in developing new homogeneous catalyzed hydroformylation processes to convert fatty acid methyl esters to fatty aldehyde-esters as part of an initiative to produce new polyols based on renewables.- Designed, constructed and operated a continuous pilot plant to evaluate effect of operating conditions on reaction kinetics, extraction & distillation performance, and catalyst (Rhodium-Ligand) stability during long-term operation.- Developed novel reactive-extraction technology using a solvent & syn-gas to separate products from catalysts and to convert Rh-Linoleic Aldehyde complexes to desired Rh-Ligand complexes that are recoverable by the extraction.- Demonstrated new technology in a 3 month demonstration run (continuous operation, 24/7) showing economically viable levels of rhodium loss.

Doctor Of Philosophy (Ph.D.), Chemical Engineering

Bachelor’S Degree, Chemical Engineering