Bryan Ferguson Email & Phone Number

Cambridge, Ma, Us

Cambridge, Ma, Us

Boston, Massachusetts, Us

I worked on a team investigating the effect of age and neuroinflammation on meningeal lymphatic function. I worked to develop bulk RNA-seq and scRNA-seq sample workflows from mice and rats in order to generate high dimensional datasets capable of informing target identification and therapeutic development. I also helped develop IHC protocols to study meningeal T cell localization and VE-Cadherin endothelial cell-cell junctions. Finally, I trained to carry out rodent survival surgeries for an in vivo imaging assay measuring CSF drainage to the deep cervical lymph nodes (dCLNs)

Cambridge, Ma, Us

I serve as a committee member for the Broad’s Data Access Committee. I help oversee access to the Broad’s new controlled-access data repository of genomic and exomic human clinical data.

Cambridge, Ma, Us

I work in the Schreiber Lab in the Chemical Biology and Therapeutics Science Program investigating the potential applications of ApoE lipoprotein and apoE-related biology as a novel therapeutic target to treat various forms of neurodegeneration, including late onset Alzheimer’s disease (LOAD). My work has helped elucidate important differences in isoform-dependent differences in lipoprotein trafficking, which constitute novel and potentially important insights into how apoE isoforms either confer protection or risk for the development of LOAD. I have also helped lead studies demonstrating sensitivity of microglia and astrocytes to ferroptosis, modulation of ferroptosis sensitivity by mciroglial state polarization and small molecule treatment, as well as phagocytosis of lipid debris.

Cambridge, Ma, Us

I served as the committee co-chair of Out@Broad, the Broad Institute’s LGBTQIA+ employee resource group. I help lead transformative efforts to foster a more inclusive environment at the Broad in order to empower LGBTQIA+ members of the scientific community. These efforts include but are not limited to developing a comprehensive policy to create universal gender-inclusive bathrooms in order to foster a more gender affirming environment at the Broad. I have also led workshops focused on the epidemic of sexual violence of in the LGBTQIA+ community. I also helped in the response and press release for the genome-wide association study of “same-sex sexual behavior” published out of the broad (https://www.broadinstitute.org/blog/opinion-seeking-justice-age-genomics-and-call-higher-ethical-standards-research-involving-human).

Belmont, Ma, Us

I worked as a Mental Health Specialist, providing counseling to trauma survivors in individual and group settings focused on symptom stabilization and management using techniques rooted in cognitive behavioral therapy (CBT) and dialectical behavioral therapy (DBT).

Clinton, N.Y., Us

Investigated changes in cultural identity of Latin American immigrants and the construction of new collective identities in Utica, NY. Results demonstrated the role of material needs as a basis for community building and the role activists and community organizers may play in the evolution of new communities and collective identities.

Worked to synthesize a novel nanoparticle capable of encapsulating and releasing insulin in response to increased blood glucose as part of an experimental closed loop insulin therapy.

Clinton, N.Y., Us

Investigated the role of negative intrinsic curvature of lipid membranes on the translocation of the antimicrobial peptide piscidin as well as its ability to translocate into bacteria and bind nucleoid DNA. My work was published in the Journal of Physical Chemistry B in the fall of 2015.

Master Of Science - Ms, Biotechnology

Bachelor Of Arts - Ba, Biochemistry And Molecular Biology, Hispanic Studies