Bryan Cosca Email & Phone Number

Scrum Master for NGS Bioinformatics, lead Agile meetings and fostered communication between stakeholdersSupported Genome Assembly automated pipeline development using NextflowCreated front-end variant summary tables and plots using Jinja and Snowflake

Owner of bioinformatics and data analysis portion of Ginkgo COVID-19 WGS pipelineAutomated processes in the pipeline and data delivery portions to increase both wet-lab and dry-lab FTE efficiency.Delivered tens of thousands of pooled swab, wastewater, and samples to 10+ customers meeting contracted TAT by > 99%Aided in finding one of the first omicron.

Tracked metrics for COVID-19 sequencing using TableauAdded automated slack notifications to notify team when data is ready for analysis

Data curation and analysis of LIMS dataBuilt Variant Calling and RNA-seq pipelines using both CWL and WDL

Responsible for production bioinformatics workflows that processed 10-50 TB per monthManaged a team of bioinformaticians using Agile and Scrum practicesReduced cost and improved processing efficiency of bioinformatics workflows by utilizing parallelization and multithreading across hundreds of cloud compute nodesBenchmarked bioinformatics tools for.

Rewrote the Veritas production pipeline to run on Arvados using CWL in order to scale to processing hundreds of genomes in parallelProvided account management, training and issue resolution to Arvados customers on multiple cloud platforms and on premise clustersCreated open source Bash and Python tools to increase self-efficiency using Arvados

Developing bioinformatic pipelines on our open source platform: https://github.com/curoverse/arvadosPresented Arvados demos, both in person and through a self-produced video demo, to prospectivecustomersRewrote customer bioinformatics workflows to work on ArvadosBenchmarked various open source DNA variant callers and DNA aligners to provide.