Bryan Naidenov, Ph.D. Email and Phone Number
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Machine learning industry scientist with expertise in mathematical modeling, machine learning, Bayesian inference, and artificial intelligence in the pharmacological space.• 8 years of R&D experience in quantitative modeling & algorithm design for trait prediction, biomarker identification, and drug discovery.• Modeling expertise: Deep learning, Bayesian modeling, variational inference, causal inference, uncertainty estimation, transformers, self-supervised LLMs, (mixed) linear programming, model validation, hypothesis testing, BLUPs, RKHS regression, and general Monte Carlo methods.• Assays: High-throughput sequencing (scRNA-seq, DRUG-seq, DNase-seq, Perturb-seq, ATAC-seq, ChIP-seq), phenotypic screening (high-content cellular imaging), and viability screening (LDH).• Therapeutic areas: Rare disease, neurological disorders, and oncology for drug repurposing in preclinical disease models.My academic research was focused on developing deep learning models for complex polygenetic traits (grain yield, protein content, and flowering time) in staple crops, like Triticum aestivum, by learning informative Euclidean spaces for high-dimensional genomic data. Proficient in Python, R, and C++ in UNIX HPC systems.
Pfizer
View- Website:
- pfizer.com
- Employees:
- 112906
-
Senior Machine Learning Research ScientistPfizer Sep 2024 - PresentCambridge, Massachusetts, United States -
Machine Learning ResearcherTranscripta Bio Sep 2023 - Sep 2024Palo Alto, California, United StatesLead ML/AI Scientist for the drug discovery platform.- Led the development and implementation of advanced AI models for predicting drug effects on gene expression perturbations.-Oversaw cross-functional efforts to conduct comprehensive in silico screening of billions of small molecules, identifying bioactive compounds for therapeutic applications in rare neuronal diseases.-Developed and utilize generative chemistry models to discover novel drug candidates and enhance drug discovery processes through innovative quantitative and computational techniques. -
Phd CandidateOklahoma State University Aug 2017 - Sep 2023Stillwater, OkPhD candidate focusing on modeling high-dimensional genomic data with AI for crop phenotype prediction.1. Prediction of breeding values for several agronomic traits from a double haploid population of red winter wheat by deriving novel genome graphic representations and convolutional neural networks.2. Derivation of learned quantitative latent embeddings (4000 genomes from populations of lodgepole pine and white spruce) using a novel self-supervised learning objective based on incorporating genomic similarities in different contexts.3. Employed a Bayesian Hierarchical model to identify functional antimicrobial resistance genes in the domestic Salmonella enterica population as part of an association analysis. 4. Analysis of transcriptome landscape in upland cotton using polynomial models to identify relationships between domesticated transposons and promotors relating to salt tolerance. -
Technical SpecialistOklahoma State University Sep 2016 - Jul 2017Stillwater, OkTechnical staff in charge of manipulating high-throughput third-generation DNA sequencing for back-end development and quantitative modeling. 1. Developed large-scale SNP databases for maize, allowing fast variable subsetting to support various regression algorithms using Sequence Ontology (SO) queries. 2. In charge of creating a back-end for bulk data cleaning/processing/transformation using a High-Performance Computing environment. 3. Created a JavaScript-based interface for high-speed access to HDF5 formats containing SNPs, phylogenetic information, and phenotypic data with the backend written in C++.4. Worked extensively with third-generation long-read sequencing technology for constructing the genomes of drought-resistant wheat varieties. 5. Built bioinformatics pipeline for rapid multiple-sequence alignments and SNP-calling for plant genomes, using BAM/VCF formats and the optimal aligners for noisy read mapping.
Bryan Naidenov, Ph.D. Skills
Bryan Naidenov, Ph.D. Education Details
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Biochemistry And Molecular Biology -
Cum Laude
Frequently Asked Questions about Bryan Naidenov, Ph.D.
What company does Bryan Naidenov, Ph.D. work for?
Bryan Naidenov, Ph.D. works for Pfizer
What is Bryan Naidenov, Ph.D.'s role at the current company?
Bryan Naidenov, Ph.D.'s current role is Senior Machine Learning Research Scientist.
What is Bryan Naidenov, Ph.D.'s email address?
Bryan Naidenov, Ph.D.'s email address is br****@****ate.edu
What schools did Bryan Naidenov, Ph.D. attend?
Bryan Naidenov, Ph.D. attended Oklahoma State University, Kennesaw State University.
What skills is Bryan Naidenov, Ph.D. known for?
Bryan Naidenov, Ph.D. has skills like Data Science, Bioinformatics, Big Data, Biology, Programming, Computer Science, Genomics, Data Analysis, Research, Machine Learning, C++, Python.
Who are Bryan Naidenov, Ph.D.'s colleagues?
Bryan Naidenov, Ph.D.'s colleagues are Yinhui Wu, Gülden Uçak, Sai Kiran G, Chalia Atkinson, Olga Korshikova, Amy Mohsen, Jill Gu.
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