Bryce Allen Email & Phone Number

San Diego, Us

The vast complexity of biological signaling requires protein-protein interactions to impart post-translational modifications and molecules that induce protein proximity gave us paradigm-shifting medicines like rapamycin, lenalidomide, and pomalidomide. Yet, 95% of nature’s E3 ligase-substrate chemical space remains unmapped for its enormous potential - until now. At Differentiated Therapeutics we’re combining breakthroughs in biophysics, molecular simulation, AI, and automation to map the conformational basis of induced proximity and to use that map to design novel degrader therapeutics. Led by Bryce Allen (founding Head of Integrated Data Sciences at Silicon Therapeutics), Mike Wood (founding team at Crinetics Pharmaceuticals), and Isaac Kohane (Chair of the Department of Biomedical Informatics at Harvard Medical School), we are not only changing where we look for new medicines but also the speed and scale at which we find them. We’ve built a world-class team and a pioneering drug discovery platform that has already produced a robust pipeline of assets. We are scaling our validated physics-based AI-driven platform built on the largest E3-substrate dataset to advance the first of our preclinical programs to IND-enabling studies.

Boston, Ma, Us

Taught Integrated Experiential Learning; Data Science/AI applied to Drug Discovery

* Demonstrated ability to create and articulate a compelling long-term vision and implement and execute an aligned strategy that has ensured high quality outcomes* Developed a broad computational and data platform that integrates biophysical, molecular simulation, chemical and clinical data* Provides scientific leadership to data sciences team; leads efforts to create novel tools and to establish routine computational and data sciences practices to screening, compound characterization, preclinical and clinical studies* Works with other expertise teams and the executive leadership team to develop/adjust the STX strategy and operational plans that will be key to the company's success* Provides strategic and operational leadership for the Biology team, providing scientific oversight and direction, and ensuring effective project progression* Retains and recruits top talent, mentors the team with emphasis on people development, leadership, and culture* Works with other expertise teams to align and prioritize software engineering, pipeline standardization, and data visualization capabilities as key accelerators for the STX innovation pipeline* Serves as a member of research leadership team along with leaders of Chemistry, Biology, and Clinical translational studies, to set strategy, manage resources, and oversee personnel decisions across research* Works closely with project leads, chemistry, computational biology, clinicians, and translational medicine to ensure smooth and effective transitions of project assets into the clinic* Supports the execution of R&D programs in business development partnerships* Drives and supports IP development of STX Intellectual Property portfolio

Contributed to the architecture and development of data storage, query and analysis infrastructure – SciDB, Hadoop, MapReduce, Impala, Python. Developed and maintained custom ETL processes and machine-learning models for chemical and genomic entities used in the Library of Integrated Network-based Cellular Signatures (LINCS) from multiple sources. Led a team developing web tools and applications to facilitate knowledge-based visualization and analysis of diverse multi-dimensional LINCS datasets.

Multimedia application development leveraging causal inference and environmental interactivity

Postdoctoral Fellow, Biomedical Informatics

Doctor Of Philosophy - Phd, Molecular And Cellular Pharmacology

Bachelor Of Science - Bs, Biochemistry