Caleb Chase Email & Phone Number

Tokyo, JP

Tokyo, JP

• Downstream lead of vector PD group, focusing on LVV platform development
• Subject matter expert of downstream unit operations (TFDF, chromatography, NFF, UF/DF)
• Led downstream process scale-up design and planning
• Directed weekly downstream team meetings focusing on experimental planning, assigning responsibilities, and reviewing data
• Frequent presenter of DSP studies to PD organization
• Authored work instructions for various unit operations, unit operation development summary reports, and reviewed electronic lab notebook entries

• Supported LVV platform development through execution of bench-scale experiments
• Led capture chromatography screening, selection, and development efforts
• Conducted analytical testing and analysis for product infectivity (TU), physical particles (p24), and total impurities (protein, DNA)
• Authored electronic lab notebook entries and updated experimental templates
• Managed one co-op to advance downstream process development objectives

Thousand Oaks, CA, US

Bioprocess Sciences & Technologies - DownstreamDownstream lead for an external PD program (CDMO) in late stage development. Responsible for control strategy documentation and supporting tech transfer activities to commercial manufacturing site.Execute purification development activities encompassing early and late stage development. Screen, optimize, and.

Thousand Oaks, CA, US

• Prepped and tested trauma foam delivery system under various dosages/conditions and completed ensuing foam characterization for efficacy and specification purposes
• Developed new foam formulations and tested foam performance on small scale with a focus on enhancing chemical functionality to maximize product efficiency for the end user
• Developed method to determine mixing ratio of two-phase system and assessed various delivery system configurations, resulting in determination of appropriate fill volumes for product for FDA-submission
• Presented foam chemistry formulation and other lab work progress to chemistry group on a weekly basis

Prepared NMR samples for protein purification, created buffers and stock solutions, maintained cleanliness of the lab, updated chemical inventory

Watertown, Massachusetts, US

• Performed stability studies on various solid dosage drug lots using HPLC, dissolution, and Karl Fisher to test for epimer growth, percent cumulative release of drug, and moisture content respectively
• Formulated new drug lots and used a direct compression tablet machine as well as packed capsules by hand to create samples for stability studies
• Completed a stability study comparing the efficiency of coated tablets to uncoated tablets

Milford, MA, US

Lead project on heat exchanger upgrade under supervision of chief engineer: Installation Qualification (IQ): P&ID Operational Qualification (OQ): UOP Performance Qualification (PQ): verified unit met specificationsPacked and tested columns using HPLC instruments to verify that the material met specifications.Updated numerous P&IDs of reactors, dryers.

Newport, R.I., US

Worked with team of students and supervisor to construct an operational unmanned underwater vehicle that could navigate an underwater obstacle course.