Cara Young Email and Phone Number

Biopharmaceutical Drug Substance Development (BDSD) Associate Scientist July 2021 - Present Jemperli Downstream Process Development Sub-Team (Jemperli DPD Sub-Team) • Perform chromatography and filtration experiments related to the entirety of the Jemperli downstream drug development process to help develop process parameters for the most optimal production of pure Jemperli drug substance • Document and scientifically review experiments, protocols, and reports related to Jemperli… Show more Biopharmaceutical Drug Substance Development (BDSD) Associate Scientist July 2021 - Present Jemperli Downstream Process Development Sub-Team (Jemperli DPD Sub-Team) • Perform chromatography and filtration experiments related to the entirety of the Jemperli downstream drug development process to help develop process parameters for the most optimal production of pure Jemperli drug substance • Document and scientifically review experiments, protocols, and reports related to Jemperli downstream process development • Coordinate with colleagues/external professionals regarding Jemperli downstream process technology transfer to a GSK internal manufacturing site and WuXi Biologics, an external lab contract organization Show less

• Provided insights about quaternary structure and binding of 2 novel therapeutics of active Lilly projects.• Designed optimization crystallization screens and created screens using Mosquito and DragonFly software.• Conducted a partial structure refinement and solved for the final structure solution of a key compound using MOE, PyMOL, and Coot modeling software.• Analyzed over 15 years of crystallization screening data across several Lilly sites and custom designed a custom… Show more • Provided insights about quaternary structure and binding of 2 novel therapeutics of active Lilly projects.• Designed optimization crystallization screens and created screens using Mosquito and DragonFly software.• Conducted a partial structure refinement and solved for the final structure solution of a key compound using MOE, PyMOL, and Coot modeling software.• Analyzed over 15 years of crystallization screening data across several Lilly sites and custom designed a custom crystallization screen to improve initial screening efficacy based on protein availability. Show less

• Used 3D platforms for tumoroid culture/therapeutic efficacy experiments to understand cancer pathology• Cultured mesenchymal stem cells, peripheral blood mononuclear cells (PBMCs), endothelial, and patient derived cancerous cells in 2D formats• Thawed, monitored, imaged, counted, and cryopreserved aforementioned cell types in 2D formats• Prepared cell suspensions for flow cytometry analysis• Cultured tumoroid models in 384 well 3D hanging drop plates to study cell… Show more • Used 3D platforms for tumoroid culture/therapeutic efficacy experiments to understand cancer pathology• Cultured mesenchymal stem cells, peripheral blood mononuclear cells (PBMCs), endothelial, and patient derived cancerous cells in 2D formats• Thawed, monitored, imaged, counted, and cryopreserved aforementioned cell types in 2D formats• Prepared cell suspensions for flow cytometry analysis• Cultured tumoroid models in 384 well 3D hanging drop plates to study cell communication/tumor progression• Treated tumoroids with 2 common therapeutics and observed that treated tumoroids had decreased size and lower cell viability• Quantified cell types within tumoroids using flow cytometry analysis with the Flow Jo application Show less

• Tested and qualified a new furnace recipe for Nessus Deflectors increasing production capacity by 100%. • Created standard work templates and reference materials for non-standard work areas on the shop floor. • Trained all 3 shifts of employees on the new standard work instructions 2 key areas of MPP. • Performed the final qualification requirements to release the Nessus Collector 3-Braze process which will increase production capacity by 50%.

Emergent Behaviors of Integrated Cellular Systems (EBICS) Research Intern• Selected as one of five students to work full time on biomedical research. My research involved characterizing exosomes in order to increase stem cell potency. I learned wet lab techniques of cell culture, assay analysis, and centrifugation for the first time.• Cultured mesenchymal stem cells (MSCs) in 2D cell plates with lipid of interest• Monitored, split, and counted MSCs• Ultracentrifuged MSCs and… Show more Emergent Behaviors of Integrated Cellular Systems (EBICS) Research Intern• Selected as one of five students to work full time on biomedical research. My research involved characterizing exosomes in order to increase stem cell potency. I learned wet lab techniques of cell culture, assay analysis, and centrifugation for the first time.• Cultured mesenchymal stem cells (MSCs) in 2D cell plates with lipid of interest• Monitored, split, and counted MSCs• Ultracentrifuged MSCs and media several times to isolate exosomes• Performed nanoparticle tracking analysis on exosomes to confirm their size• Learned the basics of ELISA and western blotting• Preliminarily concluded that sphingomyelinase increases exosome production in MSCs• Won 1st place out of 22 students for my oral presentation at the GT Research Symposium. • Won 2nd place out of 16 students for my poster presentation at the annual EBICS Retreat in Illinois• Strengthened my networking, teamwork, scientific writing, and presentation skills. Show less

Undergraduate Research Opportunities Program (UROP) – Shikanov Lab 2016/2017 Academic Year• Assisted in writing protocols for data analysis• Measured follicle size using the Flow Jo application• Analyzed and organized data for my mentor’s thesis publication and added as an author