Carmen Lam Email & Phone Number

Natick, MA, US

Cambridge, MA, US

Cambridge, MA, US

• Lead analytical method development and process/product characterization efforts supporting the development of a T-cell immunotherapy platform.

• Led and designed analytical methods for quantifying and assessing the activity of therapeutic proteins.

• Led the development and implementation of stable cell lines and 3-D organoids for cell-based reporter, protein, and gene expression assays to discover new medicines to treat diabetes and related metabolic disorders.
• Managed CROs and communicated with colleagues and other stakeholders, compiled results into comprehensive reports, and presented data at internal and external meetings.

Indianapolis, Indiana, US

• Led high-throughput in vitro and in vivo protein-protein interaction assay development to establish on-target mechanism-of-action for pre-Investigational New Drug (IND) lead and discovery candidates for the treatment.
• Managed progress and R&D efforts for IND candidate selection: bioanalytical screening to establish structure-activity-relationships, ADME, in vitro and in vivo pharmacokinetic profiling, and in vivo efficacy of novel.
• Managed CRO relationships, reviewed contracts, prepared initial agreement drafts, and assisted outside corporate counsel.

• Maintained current knowledge of regulatory policies of product compliance to provide best-in-class service.
• Built strong client relationships in a timely and customer-focused manner.
• Conducted toxicology risk assessments and prepared reports.

Houston, TX, US

• Led a team of scientists to develop, optimize, and validate biomarker assays for tissue, immune cells, and enriched rare circulating cells in support of pre-clinical and clinical trials of multiple cancer types. Acted.
• Designed and executed more than 30 target-defined biomarker assays for pre-clinical and clinical trials of multiple cancer types.
• Streamlined over 100 antibody qualifications to study prognostic biomarkers in rare cells in blood or tissues.
• Worked with Quality Assurance Director to develop risk and root cause analyses and perform CAPA.
• Managed ongoing relationships and communication, including data presentations, with scientific and clinicalinvestigators participating in ApoCell-sponsored key opinion leader studies.
• Performed high-level writing of scientific abstracts, manuscripts, and investigative reporting.

Houston, TX, US

Studied the role of epidermal growth factor receptor in tumor progression by identifying novel EGFR interacting proteins. Investigated the contribution of cancer stem cells (CSCs) to the progression of pancreatic ductal adenocarcinoma (PDA).

Houston, TX, US

Investigated the role of Apollo, a telomere-associated protein, on telomere protection, genomic instability, and aging using mouse models and shRNA-mediated gene knockdown of essential proteins in the telomere complex.