Carolina Chou Email & Phone Number

South San Francisco

Manage outsourced toxicology studies from ESR to development in the large and small molecule space.

South San Francisco

Manage in-vivo outsourced studies with Contract Research Organizations. Including IND-enabling and Early Stage Research studies.

Validated autoimmune MOG model in mice. Integrated safety toxicology studies using a modified functional operational battery. Tested venous stasis thrombosis non-survival model with heparin and EPO as a viable model. Assisted in intracerebral hemorrhage surgeries and conducted cylinder and whisker behavior tests post recovery. Collaborated and conducted PK studies in canulated rats. Evaluated the automated sampling machine (Culex) for PK studies in rats. Authored and amended IACUC protocols, data analysis, presentations, and literature searches.

Validated and conducted studies for experimental autoimmune encephalomyelitis (EAE). Continued neuropathic pain models. Conducted diabetic models in mice and rats. Pre and post surgical care. Trained animal care staff, research associates, and scientist as needed on basic routes of administration in mice and rats. Analyzed and presented data.

Neuropathic pain models of tactile allodynia and mechanical hyperalgesia. Managed mouse colony and assisted in transgenic colony breeding program. Trained in spinal cord injury in rats (dorsal hemisection). Sciatic and cortical labeling for histology. Performed implantation surgery for minipump and emitter. Animal facility husbandry.Incyte GenomicsProbes and Hybs

Responsible for various aspects of microarray fabrication and analysis. Made cDNA probes from customer RNA stocks. Hybridized probes to DNA microarrays and analyzed results. Generated and purified DNA stocks using PCR and purification columns. QC'd DNA with gel electrophoresis and Picogreen assays.

Processed data output and readied material for courier pickup. Used CAS II mainframe system to print data output. Team leader for Woodland site. Prioritized tasks and assigned them to team members. Communicated status to the next shift addressing any urgent requests or equipment failure.skillsIn vivo: Full necropsy, standard routes of administration, CSF draw, jugular blood draw, intrathecal injections, perfusionMolecular: Gel Electrophoresis, SDS-PAGE, PCR, and Picogreen Assays, DNA Microarray Analysis, ELISAsSoftware Tools: Microsoft Office, MetaMorph, ImageJ, PrismOther: Histology, H/E, Nissl staining, Cryostat