Cassandra Hamilton Email and Phone Number

Lab management as well as research support for multiple efforts both clinical and basic science research into Pancreatic and colorectal cancers; • Recombinant protein expression and purification for drug discovery research• Library preparation and coordination of sequencing from single cell or nucleic acids including 10X scRNAseq, Whole exome sequencing, and whole transcriptome sequencing• Tissue culture including mammalian, bacterial, 2D and 3D methods and molecular techniques… Show more Lab management as well as research support for multiple efforts both clinical and basic science research into Pancreatic and colorectal cancers; • Recombinant protein expression and purification for drug discovery research• Library preparation and coordination of sequencing from single cell or nucleic acids including 10X scRNAseq, Whole exome sequencing, and whole transcriptome sequencing• Tissue culture including mammalian, bacterial, 2D and 3D methods and molecular techniques • Data management for clinical studies-Management of the MRB translational core• Implementing core services for the Radiation Oncology depertment’s clinical research efforts• Providing services for these efforts including nucleic acid extraction, tissue processing and storage, and library preparation from these samples• Maintenance of services i.e. financial analysis of yearly fees, submitting fees to administration for billing• Providing guidance to new investigators on sample requirments/sequencing factors• Supervising core personnel Show less

Core lab supervisor, managing intake, processing and storage of human samples for clinical research in human genetics, including familial cardiovascular disease, autism, chronic liver disease, and genetic pulmonary disorders. Certified RPT specializing in venipuncture for research study. Collecting family history and construction of familial pedigrees tracking genetic disease and novel mutations related to those diseases. extracting DNA, plasma and serum from human samples(blood,saliva, buccal… Show more Core lab supervisor, managing intake, processing and storage of human samples for clinical research in human genetics, including familial cardiovascular disease, autism, chronic liver disease, and genetic pulmonary disorders. Certified RPT specializing in venipuncture for research study. Collecting family history and construction of familial pedigrees tracking genetic disease and novel mutations related to those diseases. extracting DNA, plasma and serum from human samples(blood,saliva, buccal swabs) as well as isolation and transformation of lymphocytes for clinical studies. Data management for clinical research of genetic pulmonary fibrosis including IRB and HIPAA, as well as coordination of blood draws and research kits.I then transferred to the department of Radiation Oncology at UTSouthwestern, helping a team of scientists to study the tumor microenvironment, Using many molecular protocols as well as helping construct libraries for deep sequencing of tumor cell heterogeneity. Show less

I began working at UTSouthwestern Medical in the early spring of 2014, in the lab of Nobel Laureate Drs. Michael Brown and Joseph Goldstein, solely responsible for the discovery of the LDL receptor and subsequent understanding of cholesterol regulation resulting in Statin class cholesterol drugs. Under their guidance as P.I.s, I have worked under a senior researcher on proteins related to the lysosomal storage disorder called Neimann Pick disease, providing assistance through molecular… Show more I began working at UTSouthwestern Medical in the early spring of 2014, in the lab of Nobel Laureate Drs. Michael Brown and Joseph Goldstein, solely responsible for the discovery of the LDL receptor and subsequent understanding of cholesterol regulation resulting in Statin class cholesterol drugs. Under their guidance as P.I.s, I have worked under a senior researcher on proteins related to the lysosomal storage disorder called Neimann Pick disease, providing assistance through molecular protocols and benchwork towards the goal of publishing scholarly papers and advancing knowledge in this field. Show less