Luca Cassetta

Luca Cassetta Email and Phone Number

VP Immunology and Co-Founder of Macomics Ltd @ Macomics
Luca Cassetta's Location
Edinburgh, Scotland, United Kingdom, United Kingdom
Luca Cassetta's Contact Details

Luca Cassetta personal email

n/a
About Luca Cassetta

Dr Cassetta is a co-Founder of Macomics and is an immunologist with in-depth knowledge of human myeloid cell biology applied to different human diseases. He obtained a PhD in immunology at the S.Raffaele Institute in Milan studying the role of macrophage polarization in HIV pathogenesis; he then moved to NY at the Albert Einstein Medical College in the lab of Prof. Jeffrey Pollard where he studied Tumor Associated Macrophages in breast cancer. He then moved to the University of Edinburgh continuing his studies on TAMs where he established his own lab as principal investigator. His extensive experience in human macrophage biology contributed to the development of the Macomics screening platform. Dr Cassetta is an author of multiple publications in high-impact international scientific journals including Cancer Cell, Nature Communications, Journal of Experimental Medicine, Blood, PNAS, Nature Reviews Drug Discovery. He was awarded the Innovation Prize cup 2019 as a young entrepreneur for the spinout company, Macomics.

Luca Cassetta's Current Company Details
Macomics

Macomics

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VP Immunology and Co-Founder of Macomics Ltd
Luca Cassetta Work Experience Details
  • Macomics
    Vp Immunology
    Macomics Aug 2021 - Present
    Edinburgh, Scotland, Gb
  • Macomics
    Founder
    Macomics Nov 2018 - Present
    Edinburgh, Scotland, Gb
  • Airicerca
    President
    Airicerca Oct 2014 - Present
    Together with Dr. Lorenzo Agoni I founded AIRIcerca, the International Association of Italian Researchers in the world (www.airicerca.org).Our main missions are to create a worldwide network of Italian researchers, to help young generation of Italian scientist to connect with colleagues in other nations and to contribute to develop novel ways to perform public engagement in Italy and abroad.
  • The University Of Edinburgh
    Principal Investigator
    The University Of Edinburgh Mar 2020 - Jul 2021
    Edinburgh, Gb
  • The University Of Edinburgh
    Postdoctoral Fellow
    The University Of Edinburgh Mar 2014 - Mar 2020
    Edinburgh, Gb
  • Albert Einstein College Of Medicine
    Postdoc
    Albert Einstein College Of Medicine Mar 2011 - Dec 2013
    Bronx, New York, Us
    In these 3 years I studied the role of wnt in breast cancer progression. The study was published on Cancer Research
  • Università Vita-Salute San Raffaele Milano
    Phd Student
    Università Vita-Salute San Raffaele Milano Jan 2007 - Feb 2011
    Milano, Milano, It
    As undergraduated and then PhD student I contributed on the elucidation of the regulation of HIV-1 replication driven by High Mobility Group Box-1 Protein (HMGB-1). HMGB chromosomal proteins have mostly been studied as factors that facilitate assembly of site-specific DNA binding proteins. However, recent studies have shown that HMGB-1 can be either passively released from necrotic cells or be actively secreted from monocytes or macrophages upon acetylation; as extracellular protein HMGB-1 is a mediator of inflammation. Since pro-inflammatory stimuli, such as the cytokines TNF-a and IL-1b, activate HIV expression I investigated the potential effect of HMGB-1 in HIV infected monocyte-derived macrophages (MDM). Surprisingly enough I discovered that extracellular HMGB1 is a potent inhibitor of HIV-1 replication without the induction of proinflammatory cytokines and chemokines (L. Cassetta et al. AIDS 2009).
  • Università Vita-Salute San Raffaele Milano
    Fellow
    Università Vita-Salute San Raffaele Milano Jan 2006 - Jan 2007
    Milano, Milano, It
    I studied Herpes Virus 1 and 2 and in particular I contributed to set up an innovative protocol for HSV1/2 infected B cell immortalization and isolation of new neutralizing antibodies; I succeded in the isolation of a potent neutralizing anti HSV1/2 antibody and the protocol was recently published in BMC Biotechnology (A. Funaro et al BMC Biotech. 2008).

Luca Cassetta Skills

Flow Cytometry Immunology Cell Biology Biotechnology Molecular Biology Breast Cancer Tumor Microenvironment Macrophage Biology Cell Western Blotting Clinical Trials Sequencing Antibodies Mouse Models Dna Protein Chemistry Animal Models Cancer Research Cell Culture Polymerase Chain Reaction

Luca Cassetta Education Details

  • Universita' Milano Bicocca
    Universita' Milano Bicocca
    Industrial Biotechnology
  • Liceo Scientifico Gb. Grassi Saronno
    Liceo Scientifico Gb. Grassi Saronno
    Liceo Scientifico
  • Postdoctoral Fellow At Albert Einstein Medical College
    Postdoctoral Fellow At Albert Einstein Medical College

Frequently Asked Questions about Luca Cassetta

What company does Luca Cassetta work for?

Luca Cassetta works for Macomics

What is Luca Cassetta's role at the current company?

Luca Cassetta's current role is VP Immunology and Co-Founder of Macomics Ltd.

What is Luca Cassetta's email address?

Luca Cassetta's email address is lu****@****.yu.edu

What schools did Luca Cassetta attend?

Luca Cassetta attended Universita' Milano Bicocca, Liceo Scientifico Gb. Grassi Saronno, Postdoctoral Fellow At Albert Einstein Medical College.

What are some of Luca Cassetta's interests?

Luca Cassetta has interest in Tumor Microenvironment, Macrophage Biology, Immunology.

What skills is Luca Cassetta known for?

Luca Cassetta has skills like Flow Cytometry, Immunology, Cell Biology, Biotechnology, Molecular Biology, Breast Cancer, Tumor Microenvironment, Macrophage Biology, Cell, Western Blotting, Clinical Trials, Sequencing.

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