Development of a separation system

Worked in a variety of technical projects in the Dutch industry

Introduction of new equipment o Draft User Requirement Specification (URS) documentso Review quotationso Participate in meetings with supplierso Review the P&ID and 3D model for an ultrafiltration (UF) systemo Design recipe logic and review functional design specification (FDS) for an UF systemo Design systems for the semiautomatic fill of intermediate and drug substance (DS) productso Design labels for the intermediate and DS bottleso Participate in the development of the plant layoutDecommissioning of old equipmento Inventory the equipment which needs to be decommissionedo Inventory the documentation and curricula associated with the equipment to be decommissionedo Write and approve a change execution plan for equipment removalImplementation in the vaccine process of a new automated filling, labeling and bagging skid o Participate in the factory (FAT) and site (SAT) acceptance tests o Review and approve the SAT protocolso Sign off as business system owner the SAT documentationo Prepare, organize and write documentation for a failure mode and effect analysis (FMEA) to evaluate the risk of mislabeling the bottleso Ensure that the label provided by the supplier corresponds with the company requirements

Feasibility study for Manufacturing Execution System (MES) implementationo Learn the stages of the vaccine manufacturing processo Analyze and compare the batch records together with operators and specialists o Assess the data from the batch records which needs to be captured in the systemo The analysis was also used by the technical department to standardize the batch records

Guide a group of MSc and PhD students through a design project related to the hybrid hearto Introduce the students to the design cycle: definition phase, idea generation phase, design and implementation phase, test and validation phaseo Teach the students the following tools: stakeholder analysis, house of quality, brainstorming, Pugh matrix, failure mode effect analysis (FMEA), project planning (Gantt chart), reportingo Guide part of the students in applying the tools to their project

Development of a mathematical model for the future of hydrogen economyo Gather data related to the CAPEX and OPEX of relevant technologieso Calculate costs of relevant technologieso Determine drivers and barriers in the implementation of relevant technologies

Sugar crystallization with antisolvent, vacuum evaporation of sugar solutions, engineering projectso Develop block schemes, PFD’s, P&ID’s and control strategies, calculate mass and energy balanceso Develop AutoCAD master sheet with P&ID symbols based on ANSI/ISA 5.1 standardo Write test protocols, do tests at laboratory and pilot scale, analyze the results and report

Design and operation of a 40 ft container 12 m3/day pilot plant for wastewater treatment through forward osmosis o Coordinate operators and students, participate in project meetings, develop project plans and reporto Develop conceptual design, mathematical model, control strategy, interlocks, PLC program, documentationo Size the main equipment, participate to HAZOP meetings, develop the test program, operation, SAT, FAT and cleaning procedures, start-up and operation

Conceptual design of a process for lactic acid production o Select the most promising route published in patents and papers based on techno-economic feasibilityo Develop the process flow-sheet, size the main equipment, calculate mass, energy balances and costs

Catalytic cyclic distillationo Write a mathematical model for (catalytic) cyclic distillation columns, develop a sizing algorithm and investigate the separation of various (reactive) mixtures o Results are included in my M.Sc. and Ph.D. thesis

Biodiesel productiono Estimate the physical properties of fatty acids using group contribution methodso Conceptual design, pinch analysis and cost calculation of a biodiesel production planto Results are included in my B.Sc. thesis