Catherine Webb Email & Phone Number

London Area, United Kingdom

London, England, United Kingdom

London, England, United Kingdom

Funded by CRUK, investigating the role of iRHOM2 in oesophageal squamous cell carcinoma.

Assistant in the marketing department with a particular focus on search engine optimisation.

Blizard Institute

PhD Student in Professor David Kelsell's group in the Centre for Cell Biology & Cutaneous Research. My project title is:The role of iRHOM2 in oesophageal squamous cell carcinomaThe aim of my project is to investigate the role of iRHOM2 in the development of oesophageal squamous cell carcinoma. This has involved identifying iRHOM2 as a novel p63 target gene (Arcidiacono 2018 et al. Nat Comm). We demonstrated that p63–iRHOM2 regulates cell survival and response to… Show more PhD Student in Professor David Kelsell's group in the Centre for Cell Biology & Cutaneous Research. My project title is:The role of iRHOM2 in oesophageal squamous cell carcinomaThe aim of my project is to investigate the role of iRHOM2 in the development of oesophageal squamous cell carcinoma. This has involved identifying iRHOM2 as a novel p63 target gene (Arcidiacono 2018 et al. Nat Comm). We demonstrated that p63–iRHOM2 regulates cell survival and response to oxidative stress via modulation of SURVIVIN and Cytoglobin, respectively. Furthermore, the antioxidant compound Sulforaphane downregulates p63–iRHOM2 expression, leading to reduced proliferation, inflammation, survival and ROS production. These findings elucidate a novel p63-associated pathway that identifies iRHOM2 modulation as a potential therapeutic target to treat hyperproliferative skin disease and neoplasia. I am currently analysing RNA sequencing of patient biopsies and investigating the role of the iRHOM2 in the immune system. Show less

London, England, United Kingdom

Treasurer of the QMUL Women in Science and Engineering society, managing the budget, organising events and running workshops.

London, United Kingdom

Research Technician in the Department of Haematology at the UCL Cancer Institute in the group of Professor Rosemary Gale and Professor David Linch. Involved in several research projects and assist in general laboratory management, including ordering consumables and equipment maintenance. The focus of the lab is investigating molecular mutations in patients with Acute Myeloid Leukaemia (AML). Projects I was involved in included screening patient samples from an MRC trial to study… Show more Research Technician in the Department of Haematology at the UCL Cancer Institute in the group of Professor Rosemary Gale and Professor David Linch. Involved in several research projects and assist in general laboratory management, including ordering consumables and equipment maintenance. The focus of the lab is investigating molecular mutations in patients with Acute Myeloid Leukaemia (AML). Projects I was involved in included screening patient samples from an MRC trial to study molecular mutations in AML and studying Isocitrate Dehydrogenase(IDH) mutants with Dr Paul Smith. This involved mapping and sequencing deletions and developing an in vitro model to further characterise the changes induced by these mutations. Show less

Institute Of Child Health

During the MRes I worked with two translational research groups. April to August 2013Working in the Gene Transfer Technology Group at the Institute for Women’s Health as part of an MRes. The aim of this project was to optimise the production and delivery of lentiviral vectors for use in gene therapy. Integration proficient lentivirus and integration deficient lentivirus (IDLV) vectors were made and titred using a p24 assay and q-PCR. IDLVs show potential in gene therapy as they are… Show more During the MRes I worked with two translational research groups. April to August 2013Working in the Gene Transfer Technology Group at the Institute for Women’s Health as part of an MRes. The aim of this project was to optimise the production and delivery of lentiviral vectors for use in gene therapy. Integration proficient lentivirus and integration deficient lentivirus (IDLV) vectors were made and titred using a p24 assay and q-PCR. IDLVs show potential in gene therapy as they are safer and also may provide more consistent expression. Vectors were tested in vitro and preclinically. A range of different virus was used and the efficiency of the virus was tested using GFP ELISA and whole body bioluminescence imaging was performed to measure luciferase activity. A HDAC inhibitor, Trichostatin A (TSA), was used to try and improve efficiency of expression. January to March 2013Working with Dr Erwin Pauws at the Birth Defects Research Centre, which is part of the UCL Institute of Child Health. The objective of this project was to investigate the pathogenesis of tracheal hyperplasia in a Crouzon mouse model. The C342Y mutation in Fibroblast growth factor receptor 2 (Fgfr2) is the most common mutation in humans and a mouse model with this mutation has been created. Histology techniques such as embedding, sectioning and staining were used to consider the morphology of E12.5, E13.5, E14.5 mouse embryos. In situ hybridisation with RNA and LNA probes was used to study the expression domains of Fgfr2 and Sox9. PCR was used to determine the genotype of the embryos used. I was able to determine that Sox9 and Fgfr2 are expressed in the trachea as early as E12.5 and that the genes are involved in the development of the cartilage which causes a tracheal cartilaginous sleeve in a mouse model of Crouzon syndrome. Show less

Worked on the British Chinese Adoption Study, helping with research and data entry. The study has now been published in a book, Adversity, Adoption and Afterwards; A mid-life follow-up study of women adopted from Hong Kong (Julia Feast, Margaret Grant, Alan Rushton, John Simmonds and Carolyn Sampeys, 2013)

Doctor Of Philosophy - Phd, Molecular Biology

Master'S Degree, Biomedical Sciences, General

Bachelor Of Science (Bsc), Biology And Mathematics