Principal Scientist
Current
May 2023 - Present
Who is Ce Shi? Overview
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Ce Shi is listed as Principal Scientist at Merck, based in United States. AeroLeads shows a matched LinkedIn profile for Ce Shi.
Ce Shi previously worked as Investigator, Chemical Biology at Gsk and Senior Research Scientist at Promega Corporation. Ce Shi holds Phd, Chemistry from Stony Brook University.
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Merck
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Profile bio
About Ce Shi
• Dynamic, goal-oriented Ph.D. Scientist, over 10 years of experiences as a synthetic organic and medicinal chemist with strong publication record;• Expertise in transition metal catalysis, heterocycle chemistry, nucleoside/nucleotide chemistry, lipid chemistry, bio-conjugate chemistry and multi-stepl synthesis of bioactive natural products; skilled in synthesis, isolation, purification and characterization of biomolecules, particularly nucleoside /nucleotide derivatives; Well acquainted with HPLC, Mass Spectrometry and NMR spectroscopy;• Extensive experiences in medicinal chemistry and chemical biology research including rational drug design, molecular probe development, HTS lead identification, SAR improvement; • Work efficiently in multi-disciplinary research teams; Able to manage multiple projects simultaneously and deliver the targets under stringent timelines;• Strong interpersonal and communication skills; Proficient in presentation and scientific writing;• Supervisory experiences include mentoring junior/senior level scientists;
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Ce Shi's current company
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7 roles
Ce Shi work experience
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Investigator, Chemical Biology
Dec 2021 - May 2023
Senior Research Scientist
Apr 2018 - Dec 2021
Research Scientist
Dec 2014 - Apr 2018
Research Associate
Development of Antitubercular Agents Targeting Biotin Ligation in Mtb: • Design and synthesize novel nucleoside-based anti-TB agents;• Developed efficient synthetic routes to novel adenosine-like nucleosides; • Work closely with microbiologists on structure activities relationships (SAR) analysis;Development of Mechanism-Based Probes for Structural Biology Studies on NRPS Proteins:• Provided critical chemical information to structural biologists for probe design;• Efficiently synthesized vinylsulfonamide-adenosine probes for adenylation processes studies;• Chemoenzymatically synthesized the CoA analogs for condensation processes studies;• Biochemically characterized the efficacy of molecular probes in enzymatic processes; • Successfully applied these molecular probes in various NRPS biosynthetic pathways;Management of internal and external collaborations with various academic and industrial groups: • Synthesize and deliver the compounds on demand in a timely manner; • Provide medicinal chemistry insight for general research strategies and analog design; • Maintain the internal database for various projects with the external collaborators;• Provide technical support to collaborators for troubleshooting synthetic chemistry problems;
Oct 2011 - Dec 2014
Postdoctoral Associate
Development of Antitubercular Agents Targeting Biotin Biosynthesis in Mtb:• Designed and synthesized novel dihydropyridone analogs with unique mechanism of action;• Developed efficient synthetic routes to allylic amines bearing acyclic/cyclic structures;• Provided key chemical probes for the design of a continuous assay for target enzyme;Discovery of Novel Vaccine Adjuvants with TLR 7/8 Independent Cytokine Induction:• Improved the synthesis of aminoimidazolquinoline analogs with a novel synthetic strategy;• Designed and synthesized adjuvant-crosslinking reagents for adjuvant-vaccine development;
Oct 2008 - Sep 2011
Research Assistant
Chiral Biphenol-Based Phosphorus Ligands in Pd-Catalyzed Asymmetric Allylic Amination:• Designed and synthesized a large library of phosphoramidite and phosphonite ligands for asymmetric transition metal catalysis;• Successfully applied the ligands in Pd-catalyzed asymmetric allylic amination reactions which are key steps in total synthesis of bioactive natural products;
Aug 2003 - Aug 2008
2 education records
Ce Shi education
Phd, Chemistry
Stony Brook University
Bachelor Of Science (B.S.), Chemistry
Nankai University
FAQ
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What company does Ce Shi work for?
Ce Shi works for Merck.
What is Ce Shi's role at Merck?
Ce Shi is listed as Principal Scientist at Merck.
Where is Ce Shi based?
Ce Shi is based in United States while working with Merck.
What companies has Ce Shi worked for?
Ce Shi has worked for Merck, Gsk, Promega Corporation, University Of Minnesota, and Stony Brook University.
How can I contact Ce Shi?
You can use AeroLeads to view verified contact signals for Ce Shi at Merck, including work email, phone, and LinkedIn data when available.
What schools did Ce Shi attend?
Ce Shi holds Phd, Chemistry from Stony Brook University.
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