Cécile Fligny Email & Phone Number

Bordeaux Area, France

Setting-up and management of national and European collaborative projects, in the frame of multiple funding programmes: H2020 (Societal Challenges), FP7 (Cooperation), EUREKA/Eurostars, EuroBioMed, Programme d’Investissements d’Avenir (PIA/RHU), EIT Food.Contribution to the setting-up of collaborative projects in the fields of health, e-health, biotechnology & agri-food:- Analysis of funding opportunities - Technical and economic feasibility studies, definition of project… Show more Setting-up and management of national and European collaborative projects, in the frame of multiple funding programmes: H2020 (Societal Challenges), FP7 (Cooperation), EUREKA/Eurostars, EuroBioMed, Programme d’Investissements d’Avenir (PIA/RHU), EIT Food.Contribution to the setting-up of collaborative projects in the fields of health, e-health, biotechnology & agri-food:- Analysis of funding opportunities - Technical and economic feasibility studies, definition of project architectures according to the needs and expected outcomes (socio-economic impacts, dissemination targets, commercialisation perspectives) - Partner search, consortium building- Setting-up of the project budgets- Proposal writing- Definition of progress indicators- Administrative tasks related to the setting-up and submission of project proposalsTechnical, administrative and financial follow-up of European projects in the fields of health & agri-food- Project management: negotiation with the EC, contractualisation, writing of consortium agreements, organisation and chairing of consortium meetings and project reviews with EC representatives- Technical and financial reporting- Administrative follow-up: interactions with EC scientific/policy officers and National Contact Points, management of project amendments, etc.- Contribution to dissemination actions (project website contents, communication materials, etc.) Show less

Brussels Capital Region

Brussels Capital Region

- Overall reflection on my career through the comparison of research management cultures between Europe and the USA (research organization, public-private partnerships, publication strategy, research funding) during several stays abroad: USA (2x 3 months), Portugal (1 month), short stays in Europe (Brussels, Berlin, Rome).- Training in Project Management (Project Management Professional, Seattle, WA - USA).- Volunteering at the Northwest Sarcoma Foundation (Seattle ) and at the… Show more - Overall reflection on my career through the comparison of research management cultures between Europe and the USA (research organization, public-private partnerships, publication strategy, research funding) during several stays abroad: USA (2x 3 months), Portugal (1 month), short stays in Europe (Brussels, Berlin, Rome).- Training in Project Management (Project Management Professional, Seattle, WA - USA).- Volunteering at the Northwest Sarcoma Foundation (Seattle ) and at the French Blood Establishment and the Biomedicine Agency. Show less

Région De Bruxelles, Belgique

Cell-based Medicinal Products, Cell Therapy, Orthopedics.- Wrote reports related to nonclinical studies performed by the Company for the submission of an Investigational Medicinal Product Dossier (IMPD) to the European Competent Authorities. In particular, summarized the rational for the use of specific animal models and specific doses of the medicinal product for nonclinical pharmacology, pharmacokinetics & toxicology. - Validated an analytical procedure (quantification method… Show more Cell-based Medicinal Products, Cell Therapy, Orthopedics.- Wrote reports related to nonclinical studies performed by the Company for the submission of an Investigational Medicinal Product Dossier (IMPD) to the European Competent Authorities. In particular, summarized the rational for the use of specific animal models and specific doses of the medicinal product for nonclinical pharmacology, pharmacokinetics & toxicology. - Validated an analytical procedure (quantification method of the medicinal product) and wrote the validation report according to ICH guidelines. - Assisted with the development and implementation of Standard Operating Procedures (SOP) and common work practices within the clinical team (10 persons). Show less

Seattle, Washington, États-Unis

Vascular and Renal Biology, Kidney Fibrosis.- Investigated the role of pericyte-derived Connective Tissue Growth Factor (CTGF) in the regulation of renal microvascular stability and assisted with the investigation of the role of pericytes and vascular progenitors in kidney homeostasis and regeneration.- Explored the CTGF signaling pathways in mouse primary kidney pericytes and myofibroblasts following kidney injury. In particular, collaborated with 2 Academic labs & a Pharma… Show more Vascular and Renal Biology, Kidney Fibrosis.- Investigated the role of pericyte-derived Connective Tissue Growth Factor (CTGF) in the regulation of renal microvascular stability and assisted with the investigation of the role of pericytes and vascular progenitors in kidney homeostasis and regeneration.- Explored the CTGF signaling pathways in mouse primary kidney pericytes and myofibroblasts following kidney injury. In particular, collaborated with 2 Academic labs & a Pharma Company to test and use their CTGF tools (transgenic mice, antibodies, recombinant proteins) in our models of kidney fibrosis (UUO and IRI).- Characterized a transgenic mouse model of selective ablation of pericytes (cre / lox and diphtheria toxin approaches) to study the role of these cells during homeostasis and fibrosis. Show less

Lab. Of Human Genetics Of Infectious Diseases, Paris - France

Translational Research, Observational Studies, Infectious Diseases in Children. - Managed the start of 3 worldwide multicenter observational studies in the field of the genetic predisposition to rare infectious diseases in children (sample size: 2000, duration: 10 years per study). - Created key strategic clinical documents: Protocols, Informed Consent Forms, Assent Forms, Case Report Forms, and Investigator’s Brochures, in accordance with… Show more Translational Research, Observational Studies, Infectious Diseases in Children. - Managed the start of 3 worldwide multicenter observational studies in the field of the genetic predisposition to rare infectious diseases in children (sample size: 2000, duration: 10 years per study). - Created key strategic clinical documents: Protocols, Informed Consent Forms, Assent Forms, Case Report Forms, and Investigator’s Brochures, in accordance with regulatory requirements.- Obtained approvals from Institutional Review Board / Independent Ethics Committee (IRB / IEC).- Identified, qualified, and liaised with over 40 International Principal Investigators to perform the studies.- Negotiated financial agreements with clinical sites. Show less

Paris Cardiovascular Research Center - Paris - France

Vascular and Renal Biology, Kidney Fibrosis.- Investigated the role of Tissue Transglutaminase (TG2) and Endothelin (ET-1) in the pathogenesis of kidney fibrosis and podocytopathies in hypertensive nephropathy and immune-mediated glomerulonephritis. - Validated the use of Second Harmonic Generation (SHG) microscopy as a 3D method to quantify collagen fibers in human and mouse unstained kidneys, uncovering the spatio-temporal progression of fibrosis in the renal… Show more Vascular and Renal Biology, Kidney Fibrosis.- Investigated the role of Tissue Transglutaminase (TG2) and Endothelin (ET-1) in the pathogenesis of kidney fibrosis and podocytopathies in hypertensive nephropathy and immune-mediated glomerulonephritis. - Validated the use of Second Harmonic Generation (SHG) microscopy as a 3D method to quantify collagen fibers in human and mouse unstained kidneys, uncovering the spatio-temporal progression of fibrosis in the renal compartments.- Developed an in vitro assay to study the proliferation and migration of primary kidney podocytes upon different stimulations, allowing drug target validation. - Patented the use of 2 drug targets (TG2 inhibitors and ET-1 receptor inhibitors) to treat immune-mediated glomerulonephritis. Show less

Lab. Of Molecular Genetics Of Neurotransmission, Paris - France

Cardiovascular Biology.- Investigated the Serotonin synthesis system and the action of circulating Serotonin on the cardiovascular function.- Identified a new gene responsible for the synthesis of Serotonin in non-neuronal structures, helping in the development of drugs that specifically target the expression and activity of this gene in differing tissues.- Developed the cardiovascular research area within the lab, allowing the development of novel in vitro techniques… Show more Cardiovascular Biology.- Investigated the Serotonin synthesis system and the action of circulating Serotonin on the cardiovascular function.- Identified a new gene responsible for the synthesis of Serotonin in non-neuronal structures, helping in the development of drugs that specifically target the expression and activity of this gene in differing tissues.- Developed the cardiovascular research area within the lab, allowing the development of novel in vitro techniques supporting the project, such as cardiomyocyte isolation and culture.- Developed an in vitro assay to study the beating rate of mouse primary cardiomyocytes upon different stimulations. - Established that Serotonin blood level is crucial for cardiac contractility and that variations in the level of circulating serotonin contributed to the onset and / or progression of cardiac dysfunction and failure. Show less

Department Of Developmental Biology, Paris - France

- Taught developmental biology (practice and lecture) to undergraduate students (50 students, 90hrs per year).

Doctor Of Philosophy (Ph.D.), Physiology And Pathophysiology, Summa Cum Laude

"Tryptophan hydroxylase gene invalidation in mouse: role of the circulating serotonin and implication of the maternal serotonin.

Project Management Professional (Pmp)®

The PMP® is the most important industry-recognized certification for project managers.

Master'S Degree, Physiology And Pathophysiology, Summa Cum Laude

Awarded a 3-year PhD Fellowship from the French Ministry of Education, Research, and Technology, based on university criteria