I am a scientist with broad experience in the design and support of drug discovery research programs and mechanistic toxicology. Strength in the integration of chemistry, pharmacology, metabolism, kinetics, and toxicology knowledge to guide decisions in drug discovery and development.My goal is to assist small to medium size pharmaceutical companies in discovery and development of small molecules and biologicals. I am available to companies which need an experienced preclinical team member but do not desire to commit to a full time position.General Capabilities•Demonstrated ability to build scientific consortia across disparate disciplines with both domestic and international research institutions to address complex scientific problems.•Broad experiences in both basic and applied research environments. •Experience in cross discipline international technical operations (EU, Japan, China, India). •Significant experience in report, grant and proposal writing.•Excellent writing, presentation and communication skills.•Builds consensus, draws others together around ideas. Recognized for Technical Expertise in Following Methodologies:Drug Metabolism and PharmacokineticsDesign and conduct of single and repeat dose rodent, canine, and non-human primate pharmacokinetic, disposition and metabolism studies.Extensive capabilities in the use of in vitro methodologies for mechanistic investigation of biotransformation, pharmacology and toxicology.Transporter and metabolism studies using Caco-2, isolated perfused rat kidney, isolated perfused rat liver, Ussing chamber, and in situ perfused intestine models.In vivo and in vitro Drug-Drug interaction studies.Identification of metabolites.Use of transgenic animals to investigate metabolic and toxicological endpoints.Whole Body Autoradiography (WBA) studies. Modeling and SimulationPK, PBPK, PK/PD modeling. Interspecies scaling of pharmacokinetics to select clinical doses.