o Spearheaded optimisation of scientific operations at two company sites. Led multiple working groups to:- Better define and streamline laboratory processes- Generate process maps, tracker templates and SOPs- Establish searchable data records for future process improvement and troubleshooting- Assess and improve process robustness and reproducibility- Create cost/pricing templates that accurately reflect necessary project resources- Implement lessons learnt from completed projectso Worked cross-functionally with the scientific and business teams to create estimates and proposals for client projects.o Managed projects by liaising with the scientific team and clients to ensure effective communication and milestones were met.

Cellular Generation and Phenotyping (CGaP) Core Facility:o Led a team of 5 to 6 people to deliver multiple projects for faculty teams. Projects:- INSIGNIA (Sep 2015 – Dec 2018). Derivation of induced pluripotent stem cells (iPSC) lines from 100 diseased blood samples and characterization of pluripotency ; subcloning of 250 iPSC lines. - "Interferon (IFN) response" project (Jan 2016 - Mar 2017). Banking and stimulation with IFN-β or Poly-I:C of 100 human primary fibroblast lines to characterize their immune response. - MacroMap (Sep 2016 – Dec 2018). Differentiation of 315 human iPSC lines into macrophages and chemical stimulations to identify associated eQTLs. - PathMap (Sep 2017 – May 2019). Banking of 100 human iPSC lines containing a targeted knock-out (KO), differentiation into macrophages and stimulation with 10 isolates of the bacteria Klebsiella pneumonia to characterize the macrophage's response to stimulation. - CRISPR-iPS (Jan 2019 – May 2019). Generation of KO iPSC lines by infecting Cas9-expressing iPSC lines derived from 40 healthy donors with a genome-wide library of guide RNAs.o Established skills in:- Motivating and developing a team - Running multiple large-scale projects in parallel - Setting up pipelines- Communicating with different faculty teams, reporting progress and issues, managing expectations- Using project management tools like project initiation documents, issue logs, capacity plans, monthly reports, Gantt charts - Dealing with personnel issues o Acted as the facility's Health & Safety (H&S) local coordinator: kept the department updated on H&S, wrote risk assessments, improved H&S practice and made them in line with the institute's policy, carried out laboratory inspections (campus-wide), reported at the institute's H&S meetings for scientific operation.

CGaP core facility: o iPSC derivation pipeline: reprogrammed fibroblasts and blood samples to iPSCs, set up the iPSC subcloning technique used at CGaP for the INSIGNIA project, optimised the fibroblast isolation process from skin biopsies, helped research assistants understand iPSC derivation and culture by training them and writing SOPs.o Line-management: two research assistants (Jan and Mar 2015, respectively).o Project management: started INSIGNIA (Sep 2015) and "IFN response" (Jan 2016) projects.o Became H&S local coordinator (Mar 2015). Publications:Zou X, Koh GC, Nanda AS, Degasperi A, Urgo K, Roumeliotis TI, Agu CA, Badja C, Momen S, Young J, Amarante TD, Side L, Brice G, Perez-Alonso V, Rueda D, Gomez C, Bushell W, Harris R, Choudhary JS, Genomics England Research Consortium, Jiricny J, Skarne WC, Nik-Zainal S. A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage. Nat Cancer. 2021 Jun;2(6):643-657.Kucab JE, Zou X, Morganella S, Joel M, Nanda AS, Nagy E, Gomez C, Degasperi A, Harris R, Jackson SP, Arlt VM, Phillips DH, Nik-Zainal S. A compendium of mutational signatures of environmental agents. Cell. 2019 May 2; 177(4):821-836.

o Supported customers with product troubleshooting assistance.

Following a lab move to London, I followed up on the skin project I started in Cambridge.Publications:Rognoni E, Gomez C, Pisco AO, Rawlins EL, Simons BD, Watt FM, Driskell RR. Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing. Development. 2016 Jul 15;143(14):2522-35.Gomez C, Chua W, Miremadi A, Quist S, Headon DJ, & Watt FM. The interfollicular epidermis of adult mouse tail comprises two distinct cell lineages that are differentially regulated by Wnt, Edaradd and Lrig1. Stem Cell Reports. 2013 Jun 4; 1(1):19-27.

Worked at understanding how skin is compartmentalized and how epidermal stem cells interact with their environment to form specialized structures. Showed evidences for a distinct population of cells at the origin of the scale compartment in mouse tail epidermis.

Project 1: Investigated the mechanisms regulating the final number of somites (=embryonic structures at the origin of the vertebrae) in the embryos of different species, in particular the corn snake (Pantherophis guttatus). Publications:Gomez C, Pourquié O. Developmental control of segment numbers in vertebrates. J Exp Zool B Mol Dev Evol. 2009 Sep 15;312(6):533-44. Review.Gomez C, Özbudak EM, Wunderlich J, Baumann D, Lewis J, Pourquié O. Control of segment number in vertebrate embryos. Nature. 2008 Jul 17;454(7202):335-9. Project 2: Studied the role of the gene Tbx6 in the early steps of myogenesis in Xenopus laevis. Publication:Li HY, Bourdelas A, Carron C, Gomez C, Boucaut JC, Shi DL. FGF8, Wnt8 and Myf5 are target genes of Tbx6 during anteroposterior specification in Xenopus embryo. Dev Biol. 2006 Feb 15;290(2):470-81.