Céline M. Dubé, Phd Email & Phone Number

Vancouver, Bc, Ca

Burnaby, British Columbia, Canada

Summary/Job PurposeI support the in vivo pharmacology research program and contribute to the multidisciplinary research team by designing and executing in vivo studies to determine pharmacokinetics and pharmacodynamics relationships and the efficacy of optimized leads. I have strong knowledge and experience in setting up animal seizure/epilepsy models.Essential Duties And Responsibilities• Lead project, plan, design, and implement animal studies of pharmacodynamics and… Show more Summary/Job PurposeI support the in vivo pharmacology research program and contribute to the multidisciplinary research team by designing and executing in vivo studies to determine pharmacokinetics and pharmacodynamics relationships and the efficacy of optimized leads. I have strong knowledge and experience in setting up animal seizure/epilepsy models.Essential Duties And Responsibilities• Lead project, plan, design, and implement animal studies of pharmacodynamics and efficacy for lead optimization, DTC programs.• Design, conduct, and analyze experiments.• Represent Pharmacology in project teams.• Prepare technical reports for research findings and IND filings.• Compliance with CCAC protocols and regulations in conducting general research duties within assigned areas of responsibility.• Prepare, organize, interpret, in-depth analyze data for presentation, present data and reports on project status at individual, group, departmental and inter-departmental research meetings.• Responsible for the direct reports' training, coordination, management, reviewing performance, and career development.• Maintain laboratory notebook in a complete, consistent, and concise manner following company intellectual property policies and practices.• Adhere to good health and safety practices, comply with applicable EH&S rules, and participate in mandatory safety training programs.• Strong scientific expertise with a good track record of publicationsKnowledge/Skills/Abilities• Strong communication skills, excellent work ethic, self-motivation, and ability to work effectively in a team environment or independently.• A strong understanding of in vivo Pharmacology, PK, and PD concepts • In vivo skills include animal dosing with different routes, blood/tissue collection, perfusion, necropsy, clinical observation, rodent survival surgeries, behavioral assays, seizure assays, EEG and imaging modalities.• Advanced GraphPad Prism, Softmouse and ELN notebook knowledge. Show less

Departments Of Anatomy/Neurobiology And Pediatrics

I study the mechanisms involved in the generation of experimental long febrile seizures and in their consequences. I demonstrated that fever mediators such as proinflammatory cytokines, are involved in the generation of febrile seizures as well as in the development of epilepsy (Dubé et al.,J. Neurosci., 2010).I advocated Magnetic Resonance Imaging (MRI) as an attractive tool to define markers for adverse outcomes after long experimental febrile seizures because in humans prospective… Show more I study the mechanisms involved in the generation of experimental long febrile seizures and in their consequences. I demonstrated that fever mediators such as proinflammatory cytokines, are involved in the generation of febrile seizures as well as in the development of epilepsy (Dubé et al.,J. Neurosci., 2010).I advocated Magnetic Resonance Imaging (MRI) as an attractive tool to define markers for adverse outcomes after long experimental febrile seizures because in humans prospective and retrospective studies suggest that a subpopulation of children with long FS may be at risk for epilepsy, cognitive deficits and emotional dysfunction. Markers for this “at-risk” population are lacking. I discovered appropriate predictive biomarkers for cognitive deficits and for epileptogenesis after long febrile seizures. These markers are clinically relevant. ( Choy et al., under review 2013; Dubé et al.,J. Neurosci., 2010;Dubé et al., Exp. Neurol., 2009, Dubé et al., Ann. Neurol., 2004).Submitted two NIH R01 Grants: “Origins of depression in temporal lobe epilepsy”, “Developmental epilepsy-more than seizures”. Serving as liaison to and developed relationships with regulatory committees (IACUC [institutional animal care and use committee]; IBC [institutional biosafety committee]) .Coordinator for the Special Interest Group “Basic Neuroscience” at the annual meeting of the American Epilepsy Society from 2009 to 2012.Member of two committees at the American Epilepsy Society: Scientific Program Committee ( 2012 to present) and Investigator and Clinical Investigator Workshop committee, starting 2013.Facilitating a cohesive and collaborative work environment amongst an international team of postdoctoral fellows, research associates and graduate students.Supervision of Postdocs, PhD, and undergraduate studentsSelected publications: http://scholar.google.com/scholar?q=Celine+M+Dube Show less

Departments Of Anatomy/Neurobiology And Pediatrics

I developed an immature rodent model of febrile seizures. I catapulted the model into one that literally “opened up” the research field on long febrile seizures and their relationship to epilepsy. I carried out the first prospective study demonstrating that experimental long FS induce recurrent spontaneous seizures later in life in 35% of the rats (Dubé et al., Brain, 2006). The impact of this finding among the clinicians was tremendous.I studied some of the mechanisms involved in the… Show more I developed an immature rodent model of febrile seizures. I catapulted the model into one that literally “opened up” the research field on long febrile seizures and their relationship to epilepsy. I carried out the first prospective study demonstrating that experimental long FS induce recurrent spontaneous seizures later in life in 35% of the rats (Dubé et al., Brain, 2006). The impact of this finding among the clinicians was tremendous.I studied some of the mechanisms involved in the generation of experimental long febrile seizures and in their consequences (Dubé et al., Ann. Neurol., 2005).I participated to the discovery of functional and structural changes in the hippocampus after chronic early life stress, resulting in cognitive decline. Design research projects: Assess material and methods required for the projects. Conduct experiments as well as analyses in a timely manner.Manage, train and mentor postdoc fellows, graduate and undergraduate students.Organizer and Moderator of a Clinical Investigators’ Workshop: Magnetic Resonance Imaging changes after Prolonged Febrile Seizures and Temporal Lobe Epilepsy: what basic science can we learn from clinical studies and vice versa? Annual meeting of the American Epilepsy Society, Boston December 4-8, 2009.Panel organizer: Biomarker for epileptogenesis. 10th WONOEP meeting, Hungary, June 2009Ad hoc reviewer for manuscripts transmitted to scientific journals: Epilepsia, Epilepsy Research, Neurobiology of Disease, Epilepsy and Behavior, 2005 to present.Selected publications: http://scholar.google.com/scholar?q=Celine+M+Dube Show less

Irvine, Ca

Selected publications: http://scholar.google.com/scholar?q=Celine+M+Dube

Strasbourg, France. Laboratory Of Inserm U398

Selected publications: http://scholar.google.com/scholar?q=Celine+M+Dube

Doctor Of Neuroscience (Phd), Neuroscience And Biology, Honors List

Activities and Societies: Society For Neuroscience, American Epilepsy Society Selected publications.

Phd, Neuroscience