Cesca Van De Ven Email & Phone Number

Utrecht En Omgeving, Nederland

Acute lymphatic leukaemia is the most frequent occurring form of cancer in children. In 85% of these cases the leukaemia developed from the B-lymphoid lineage (B-ALL). Although more than 98% of all patients show complete remission after two months of treatment, relapse occurs in 20% of the children, after which the prognosis is poor. The initial prognosis of the disease is dependent on the underlying genetic defect, but a large part of the relapses occurring in groups with a favourable… Show more Acute lymphatic leukaemia is the most frequent occurring form of cancer in children. In 85% of these cases the leukaemia developed from the B-lymphoid lineage (B-ALL). Although more than 98% of all patients show complete remission after two months of treatment, relapse occurs in 20% of the children, after which the prognosis is poor. The initial prognosis of the disease is dependent on the underlying genetic defect, but a large part of the relapses occurring in groups with a favourable prognosis can not be predicted with the currently identified risk factors. This requires more research into new treatment strategies and the cause of the relapse. Show less

Rotterdam Area, Netherlands

Sophia Children's HospitalAcute lymphatic leukaemia is the most frequent occurring form of cancer in children. In 85% of these cases the leukaemia developed from the B-lymphoid lineage (B-ALL). Although more than 98% of all patients show complete remission after two months of treatment, relapse occurs in 20% of the children, after which the prognosis is poor. The initial prognosis of the disease is dependent on the underlying genetic defect, but a large part of the relapses occurring in… Show more Sophia Children's HospitalAcute lymphatic leukaemia is the most frequent occurring form of cancer in children. In 85% of these cases the leukaemia developed from the B-lymphoid lineage (B-ALL). Although more than 98% of all patients show complete remission after two months of treatment, relapse occurs in 20% of the children, after which the prognosis is poor. The initial prognosis of the disease is dependent on the underlying genetic defect, but a large part of the relapses occurring in groups with a favourable prognosis can not be predicted with the currently identified risk factors. This requires more research into new treatment strategies and the cause of the relapse. Show less

Utrecht Area, Netherlands

The genetics of embryonic development.Cdx and Hox genes are crucial players in embryonic axial extension. Consequently, mutations in Cdx cause a posterior shortening of the body-axis and this can be corrected by Wnt-signalling and expression of a subset of Hox genes. The last genes of the Hox-clusters have an opposite effect on the extension of the body-axis when they are expressed too early or in the wrong context. Embryos developing without any Cdx activity only develop a… Show more The genetics of embryonic development.Cdx and Hox genes are crucial players in embryonic axial extension. Consequently, mutations in Cdx cause a posterior shortening of the body-axis and this can be corrected by Wnt-signalling and expression of a subset of Hox genes. The last genes of the Hox-clusters have an opposite effect on the extension of the body-axis when they are expressed too early or in the wrong context. Embryos developing without any Cdx activity only develop a head.Besides their well known role in the spine, Cdx genes, Wnt signalling and Hox genes play an important role in correct development of the posterior part of the neural tube and the digestive system. A shortage in active Cdx genes or Wnt signalling, or aberrant early Hox13 gene expression, leads to the development of defects of the anus and rectum, which is can be found in the human Caudal Regression Syndrome. Show less

Msc, Medical Biology

Master program: Cancer genomics and developmental biology

Bsc, Biology

Education record