Chandrakant Dhanani Email & Phone Number

Ahmedabad, Gujarat, India

Team management and leading analytical team for method development, product characterization of Peptibody, Pegylated fAb, Fc-Fusion protein and Oligonucleotide (LC-MS,IEX, RP, SEC, Affinity & CE), Dynamic/Static light scattering (DLS, SEC-MALS), UV-Vis Spectroscopy and fluorescence.Operation and data interpretation of complex instrumental analytics, e. g..

Ahmedabad, Gujarat, India

• Team management and leading analytical team for method development, product characterization of carrier components (LNPs) and Oligonucleotide (IEX, RP, SEC, Affinity & CE), Dynamic/Static light scattering (DLS.
• Operation and data interpretation of complex instrumental analytics, e. g. Genetic Analyzer (Sanger Sequencing), HPLC, LC-MS, capillary gel electrophoresis.

Mumbai, Maharashtra, India

• Analytical characterization of biologics (Bacterial and Mammalian origin) using LC-MS and LC- techniques.
• Established a bio-similarity lab that is equipped with high-end equipment and quality systems.
• Leading analytical teams for Analytical characterization and comparability assessment of metalloprotease enzyme for manufacturing site change and formulation for "in situ gel" formation.
• Planning and execution of analytical work, for method development, comparability assessment, product characterization. Assessment & response to regulatory analytical queries.
• Represent analytical development in Biologics-related Late Stage CMC activities.
• Established effective systems for qualitative and quantitative analysis of Biologics by various LC method (Charge Variants, RP, SEC, Affinity, HIC, HILIC and Mix mode) in cGMP environment.

Vadodara, Gujarat, India

• Biologics & Biosimilars' analytical characterization by LCMS & LC methods.
• Product characterization and Bio-similarity assessment of biotherapeutic product by LC & LC-Ms techniques (Intact Mass, Peptide mapping, Glycan Analysis).
• Developed & delivered mass compatible charge variant method for glatiramer acetate and Nab-palcitaxel.
• Analytical Method development using QbD principles and DOE for Peptide, Drug Coated Protein Nanoparticle, and Enzyme.
• Displayed a strong commitment to successfully completing projects qualitative analysis of Peptide, Drug Coated Protein Nanoparticle and Enzyme by different LC techniques (IEX, RP, SEC, Affinity, HIC, HILIC and Mix mode).

Vadodara, Gujarat, India

• mAbs' Analytical characterization and Bio-similarity assessment by LCMS & LC-methods.
• Intact mass, Subunit mass, Peptide mapping, Sequence coverage, Amino acid modification, Glycosylation site, Glycan analysis and Disulfide bridging analysis by LC-MS.
• Qualitative analysis by SEC-MALLS, Peptide mapping, Glycan Analysis, DLS, DSC and fluorescence of FSH, Bevacizumab, Rituximab, Trastuzumab, and Aflibercept.
• Developed method for assessment of deamidation and succinimide formation with minimal method interference. Established AEX method for sialylation analysis for Hormone and Fc-fusion protein.
• Mass compatible charge variant method development for mAbs, fusion protein and peptides.
• Physicochemical characterization and biosimilarity assessment of biotherapeutic product by LC techniques (IEX, RP, SEC, Affinity, HIC, HILIC and Mix mode).

Ahmedabad Area, India

• Virus like particles and recombinant vaccine characterization
• Analytical Method development for protein refolding and Virus like particles (VLPs) formation
• Determination of hydrodynamic radius and radius of gyration using DLS and SLS techniques.
• Fermentation of bacterial and yeast expression system

Gandhidham

• Sterility establishment.
• Pyrogen & Sterility testing of Finished Product.
• Microbiological monitoring in production and QC department

Master Of Science - Ms, Biotechnology, A

Bachelor Of Pharmacy (B.Pharm.), Pharmacy, 1St Class

Qualified NET with All India Rank 30 Dec 2012 Qualified NET with All India Rank 33 June 2012 Cracked NIPER-JEE with All India Rank 243..