Charles Landry Email and Phone Number
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I have over 20 years of R&D experience and 12+ years of managerial and strategic leadership of a research function, overseeing projects from target discovery through preclinical proof-of-concept, IND filing, and support of early clinical development. ►Accomplished mentor recognized for developing talent within the organization and implementing best practices across innovation, portfolio management, and product support► Advanced knowledge of parenteral formulation development for biologics, understanding of protein chemistry, degradation pathways, and general approaches for stabilization►Advanced knowledge of biophysical techniques and ability to apply them for characterization and problem-solving during formulations development►Experience leading others in the design, execution, and interpretation of experiments to drive the definition and optimization of formulationsI also bring experience as an Assistant Professor at the University of Wisconsin-Madison, where was selected as principal investigator for three research programs to identify potential therapeutic targets for the treatment of drug addiction and sleep disorders. I delivered lectures and spoke at invited research seminars. I was recognized as first or senior author in 28 of 39 articles published in peer-reviewed scientific journals, and five first author/senior author book chapters or reviews.𝐓𝐨 𝐜𝐨𝐧𝐧𝐞𝐜𝐭, 𝐦𝐞𝐬𝐬𝐚𝐠𝐞 𝐦𝐞 𝐡𝐞𝐫𝐞 𝐨𝐫 𝐞𝐦𝐚𝐢𝐥: CFLANDRY@GMAIL.COMAREAS OF EXPERTISEBiochemistry | Immunology | Genetics | Advancing Discovery Projects in Early Clinical Development | Project Management | Nucleic Acid Therapy | Building Relationships With Internal Colleagues & External Collaborators | Fast-Paced/Start-Up Environments | Project Management | Stakeholder Engagement | Team Leadership | Timeline Management | Collaboration | Program Leadership | Grants & Laboratory Management
Scarab Genomics
View- Website:
- scarabgenomics.com
- Employees:
- 13
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Scarab GenomicsMadison, Wi, Us
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Chief Scientific OfficerScarab Genomics Jun 2020 - PresentOVERVIEW: Direct process and analytical development within the research and development department. Spearhead a diverse team of scientists and engineers responsible for analytical development, process development, technical optimization, bioprocess scale up, and analytical tech transfer. Oversee multimillion-dollar project budgets and grants for directly managed projects, ensuring functional support is available for project teams on a matrixed basis as needed. Oversaw the reengineering of K12 E. coli to produce record levels of recombinant proteins and nucleic acids that are stable, low in endotoxin, and purified ready for biopharmaceutical applications or transport into mammalian cells. SELECT HIGHLIGHTS:►Principal Investigator: Vaccine-component Production in Bacterial Cells. Secured $12.8M in grant funding after writing five NIH SBIR grants, including fast-track, phase 2, and phase 2B-Managed cross-functional research team that developed platform for high yield production of three carrier proteins used in conjugate vaccine formulations-Helped develop unique methods for carrier protein expression during bioreactor production-Established protein purification methods with production team and directed final product formulation►Project Leader: Novel Methods for Animal Vaccination. Launched $500K innovative research program, establishing a strategic partnership with an international animal health partner (Merial Animal Health) to develop a bacterial-based delivery system for animal vaccination-Negotiated research license, designed and oversaw proof-of-concept experiments in mammalian cells and vaccination studies in rodents-Spearheaded four international meetings between Scarab and Merial-Directed mammalian cell culture facility, including site setup, and contributed to US patent filing
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Senior Research And Development ScientistScarab Genomics 2008 - 2020Overview: Served as Principal investigator and project leader for this biotechnology company that has re-engineered K12 E. coli to produce high-yield recombinant proteins and nucleic acids for biopharmaceutical applications. Currently Transitioning production of the carrier protein CRM197 (used in conjugate vaccines, including Pfizer’s blockbuster pneumococcal vaccine, Prevnar) from reagent to cGMP-compliant clinical grade.SELECT HIGHLIGHTS:►Project Leader: Innate Immune Activation as a Treatment for Sepsis. Oversaw program to establish a proprietary methodology for inducing innate immune protection against sepsis-inducing pathogens and toxins-Wrote and secured $1.9M in NIH SBIR fast-track grant funding to produce a proof-of-concept-Directed and performed extensive experiments to analyze therapeutic and prophylactic treatments in a rodent model of septic shock-Filed US patent following experiment►Project Leader: Low Lipopolysaccharide/endotoxin E. coli Strains for the Production of Low Endotoxin Recombinant Protein and Plasmid DNA. Established TLR-4 sensitive HEK cell culture model to evaluate endotoxin levels in genetically altered bacterial strains, recombinant proteins, and plasmid DNA-Wrote and obtained $2M NIH SBIR phase 2 grant to explore methods for bacterial cell modifications resulting in low endotoxin bacterial strains-Filed US patent based on contributions
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Assistant ProfessorUniversity Of Wisconsin-Madison 1998 - 2008Madison, Wi, UsOVERVIEW: Selected as principal investigator for three research programs to identify potential therapeutic targets for the treatment of drug addiction and sleep disorders. Delivered lectures and spoke at invited research seminars. Recognized as first or senior author in 28 of 39 articles published in peer-reviewed scientific journals, and five first author/senior author book chapters or reviews. SELECT HIGHLIGHTS:►Oversaw $850K NIH R01-funded research to explore the influence of nicotine on adolescent rodent brain development -Identified dramatic age-specific, nicotine-induced increases in expression of unique neuronal proteins in adolescent brain regions involved in decision making and impulse control using microarray, RNA, protein, and in situ hybridization/ immunohistochemical analysis►Directed $1M NIH R01-funded research that discovered conditions associated with addictive drug use exert powerful physiological responses and resulting in dramatic changes in gene expression in rodent brain regions involved in reward response, decision making, and impulse control►Led research program examining circadian changes in the expression of genes within sleep and wake-related brain regions using microarrays-Identified genes undergoing unique patterns of diurnal regulation including brain fatty acid binding protein 7 (fabp7), which underwent diurnal changes in cytoplasmic polyadenylation and synaptic targeting and influenced learning, memory, and sleep regulation-Filed US patent surrounding methods for improving sleep and memory by altering fabp7 expression-Coached, mentored, and developed 15+ postdocs, graduate students, and technicians-Member of 10+ PhD thesis committees and chaired Neuroscience Training Program recruiting committee -
Assistant Research ScientistUcla 1996 - 1998Los Angeles, Ca, UsSELECT HIGHLIGHTS:►Developed transgenic mouse models to examine the influence on the early brain development of genes associated with the multiple sclerosis myelin basic protein genes ►Used transiently and stably transfected cell cultures from the brain to examine the potential of cells to rescue a multiple sclerosis-like disorder in mice►Established in situ hybridization techniques to follow mRNA targeting in brain cells
Charles Landry Skills
Charles Landry Education Details
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University Of TorontoNeuroscience
Frequently Asked Questions about Charles Landry
What company does Charles Landry work for?
Charles Landry works for Scarab Genomics
What is Charles Landry's role at the current company?
Charles Landry's current role is Chief Scientific Officer | Principal Investigator | Program Manager | Senior Research Scientist | Scientific Leadership.
What is Charles Landry's email address?
Charles Landry's email address is cf****@****ail.com
What is Charles Landry's direct phone number?
Charles Landry's direct phone number is +160825*****
What schools did Charles Landry attend?
Charles Landry attended University Of Toronto.
What skills is Charles Landry known for?
Charles Landry has skills like Molecular Biology, Cell Culture, Pcr, Biotechnology, Dna, Western Blotting, Neuroscience, Protein Expression, Immunohistochemistry, Biochemistry, Cell, Life Sciences.
Who are Charles Landry's colleagues?
Charles Landry's colleagues are Nicholas Liakos, Frankie Maynard, William Dunn, Scarab Genomics, John Brandon.
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