Cheryl Mathis, Ph.D. Email & Phone Number

Salt Lake City, Ut, Us

Salt Lake City, Ut, Us

Salt Lake City, Utah, Us

• Identifies risk criteria for aberrant, toxic drug metabolism using ADME principles, DMPK, and population PK modeling (R, Phoenix, NONMEM).• Quantifies the impact of drug-drug interactions on epigenetic markers using nanopore DNA sequencing methods.• Develops multiple metabolite and biomarker bioanalytical assays in accordance with FDA guidance and GCP principles.

Nottingham, Gb

• Acted as a consulting scientific subject matter expert for pharmaceutical industry clients to automate clinical trials software (e.g., informed consent, randomization, resupply) for compounds from Phase 1 to Phase 4.• Defined the project scope & program planning documents, liaised with clinical development study leaders, and coordinated resource allocation for the cross-functional development & delivery teams.• Ensured compliance with standard operating procedures, project specifications, clinical trial protocols, and clinical regulatory requirements (FDA, ICH, GCP, EMA, MHRA) including risk assessment & risk management.• Initiated and led QC investigations at each stage of the project lifecycle to identify defect root causes, implement corrective & preventative actions (CAPA) for continuous improvement, and streamline regulatory filings.• Achieved on-time or ahead-of-schedule deployment for 100% of projects managed.

Salt Lake City, Ut, Us

• Designed and executed a biophysical research project to quantify the inhibitory impact of histidine phosphorylation on 3 synthetic model peptides synthesized using biorthogonal conjugation and unnatural amino acid techniques.• Directed a PhD student on a bioanalytical chemistry research project developing fluorescent sensors requiring instruction in organic synthesis, analytical method development, and scientific communication.• Managed an undergraduate student in the synthesis of fluorogenic carbapenem analogs to report antibiotic resistance.• Achieved the successful renovation and start-up of a laboratory for chemical research with ahead-of-schedule and under-budget delivery.• Managed the laboratory for EHS/ GLP operational, chemical, and biochemical safety compliance (BSL-2) including the creation of standard operating procedures, a chemical inventory system, and a risk documentation plan for process safety.• Certified in research mentorship through the University of Utah.

Salt Lake City, Ut, Us

• Examined the mechanism of action for 5 organometallic hydrogenation catalysts active in the reduction of CO2 to methanol by quantifying structure-activity correlations, synthesizing new compounds, and spectroscopically characterizing air and water-sensitive intermediate complexes.• Investigated the synthesis & biocompatibility of several novel redox-activated MRI sensors to detect oxidative stress by leveraging Pd/ Cu/ Ni cross coupling catalysts, boronic ester reactions, and selective oxidations. Developed spectroscopic and chromatographic analytical methods to quantify catalyst activity versus a substrate library.• Managed a team of 5 undergraduate research students in chemical synthesis, data analysis, and publication of data.• Awarded the Cheves T. Walling Doctoral Dissertation Award in 2020 for the Department of Chemistry's most outstanding dissertation.

Salt Lake City, Ut, Us

• Designed and validated new synthetic experiments to revitalize the curriculum, prepared lecture presentations on synthesis, data analysis, & safety, and managed teams of 3-5 teaching assistants.• Developed and administered a pedagogical training program for 10 organic graduate student teaching assistants including weekly training, individual coaching sessions, and classroom observations.• Secured funding for an annual graduate TA mentoring position in the organic division of the Department of Chemistry. • Annually ranked as “above average” in student evaluations of both course quality and instructor excellence.

Conway, Ar, Us

• Investigated the total synthesis of active alkaloid natural products and the ruthenium catalyzed photooxidative cyclization of amino alcohols by using olefin metathesis, condensation reactions, and advanced spectroscopies.• Responsible for laboratory equipment maintenance including calibration/ repair of analytical instrumentation, chemical waste disposal, and the LIMS inventory management system.• Awarded the Department of Chemistry’s annual American Institute of Chemists Award in 2013 in recognition of demonstrated scientific ability and leadership.

Doctor Of Philosophy - Phd, Chemistry

Bachelor Of Arts (B.A.), Chemistry