Leslie Wu Email & Phone Number

Belmont, Ma, Us

Research lead for an early oncology discovery program using engineered small molecule, ADC, etc.

- Research Lead for clinical-stage rare disease programs - Design, execute and develop assays for in vivo studies for autoimmune, kidney and rare diseases - Evaluate indications and preclinical paths for early discovery programs- Lead for a small molecular inhibitor program for an autoimmune disease: design, execute, and analyze IND-enabling pharmacology studies and biomarker exploration

Waltham, Massachusetts, Us

Preclinical analytical lead supporting IND-enabling studies and novel capsid characterization

Cambridge, Ma, Us

Led and supervised Research Biology group to screen and characterize novel chemistries of antisense oligonucleotide (ASO) -establish workflow to determine target drug profile -design, execute and analyze ASO biodistribution and potency in mouse -design and perform MOA studies in vitroResponsible and accountable for preclinical studies to support IND package and platform Go/No-go decisions for Duchenne muscular dystrophy -design and execute analysis for PK, PD, target organ toxicity studies in DMD mouse models -contribute to plan, analyze and interpret NHP studies -write study reports to support regulatory submissionLed early discovery research for myotonic dystrophyProvided scientific, strategic input for research conducted in collaboration with industrial and academia partners

Cambridge, Ma, Us

Cambridge, Ma, Us

-Assay development and optimization.-Medium throughput target screening and validation.-Collaborate with and support legal/ patent information.-Train and mentor assistants

Boston, Ma, Us

Simultaneously working on 4 projects: 1. Develop bioactivity assays to determine the mechanism of actions for Insl6 recombinant protein2. Analyze/ integrate Omics data to identify novel muscle-secreted proteins with therapeutic potential3. Design project strategies and conduct metabolic phenotyping research for diet-induced obesity4. Characterize blood vessel growth in skeletal system during osteopenia • Establish muscle disease screening panels for muscle regeneration, atrophy and metabolic dysfunction• Organize reports and communicate results to lab members and our collaborator, Takeda Pharmaceuticals, Inc. • Provide genome-wide gene expression analysis and bioinformatics consultations to other lab members

Boston, Ma, Us

Genome-wide pathway & target identification for disuse muscle atrophy and cancer cachexia• Explored & validated the differentially expressed genes, microRNAs and signaling pathways in muscle atrophy• Identified target genes of NF-κB transcription factors, p50 and Bcl-3, for disuse muscle atrophy using ChIP-seq• Established the requirement of NF-κB transcription factor binding sites for MuRF1 activation• Implemented molecular targeting and pharmaceutical approaches to show the requirement of p65 for mediating catabolic effects in 4 different cytokine-induced myotube atrophy models.

Boston, Ma, Us

• Responsible for teaching lab component of the class. • Prepared teaching materials including problem sets and exams. • Supervised and assisted students to perform standard exercise tests.

Buffalo, Ny, Us

Evaluated the effect of aging/ TNFα deletion on myofiber fibrosis during muscle degeneration

Taipei, Northern Taiwan, Tw

• Assisted to study exercise training effect on left ventricular diastolic functions of post-CABG patients with diabetes.• Collected data, as part of a three-member team, by interviewing and screening for research participants, performing exercise and fitness assessments, and providing nutrition consulting and exercise training.

Phd, Applied Anatomy And Physiology

Ms, Exercise Sciences, Muscle Regeneration, Aging

Bs, Pt, Physical Therapy