Research at the GSK-Waltham site is focused exclusively on Encoded Library Technology (ELT) - a new approach to early-stage drug discovery which is complementary to traditional high-throughput screening. I manage a team of 15 chemists focused on the development of DNA-compatible reactions and subsequent application to the design and synthesis of DNA-encoded libraries (DELs). For an overview of Encoded Library Technology (ELT) and some representative hits, see:Discovery of Highly… Show more Research at the GSK-Waltham site is focused exclusively on Encoded Library Technology (ELT) - a new approach to early-stage drug discovery which is complementary to traditional high-throughput screening. I manage a team of 15 chemists focused on the development of DNA-compatible reactions and subsequent application to the design and synthesis of DNA-encoded libraries (DELs). For an overview of Encoded Library Technology (ELT) and some representative hits, see:Discovery of Highly Potent and Selective Small Molecule ADAMTS‑5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT). J. Med. Chem. 2012, 55, 7061–7079.Design, Synthesis and Selection of DNA-Encoded Small-Molecule Libraries. Nat. Chem. Biol. 2009, 5, 647-654.http://www.nature.com/nchembio/journal/v5/n9/pdf/nchembio.211.pdf Show less

(Praecis was acquired by GSK in early 2007)