Christopher Ladd Effio Email and Phone Number
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Biotechnology scientist and team leader with international experience in process and technology development for vaccines and biologics. Curious about foreign cultures and languages. Passionate about biotechnology and its socioeconomic impact in the world. RECENT ACTIVITIESModerna Technical Development:• Led definition of rapid vaccine manufacturing platform for clinical and later commercial launch of Spikevax (Moderna’s Covid-19 vaccine). Presented at Recovery conference 2022 in Rome.• Led late stage development of personalized manufacturing strategy for individualized cancer vaccine program (INT).• Built new purification team and lab for process development of plasmid DNA, enzymes and mRNA.• Moderna's high throughput automation lead. Presented at HTPD conference 2019 in Porto.Hult Business School:• Executive MBA Graduation with Distinction• Final project: China Go-to-Market Strategy Consultation for Fortune 500 companyChina Vaccine Development:• Built New Technology Department, Team and Lab from ground up for early-stage development• Created Scientific Committee and vaccine workshop for employee trainings• Late stage development and process characterization for Walrinvax (Walvax HPV virus-like particle vaccine)EXPERIENCE & SKILLSTeam and project leadership experience in the US, China and Germany, expert knowledge in:• Life science innovation (novel bioprocess, analytical technologies, lab and manufacturing automation)• Bioprocess Development (High throughput screening, Automation, Process Modeling, Chromatography, PAT)• Analytical Development (ELISA, UHPLC, method validation according to ICH)• Biologics commercialization (IND authoring, Quality by Design (QbD), CPPs-CQAs, Scale Down, Tech Transfer, RCA)• Partnerships (connecting stakeholders from academia & industry, strategic planning & execution)• Staff training and coachingSCIENTIFIC CONTRIBUTIONSThanks to collaborators, team mates and supervisors: Publication of 10 peer-reviewed research articles and multiple conference contributions across the world.
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Director, Gene Editing CmcIonis Pharmaceuticals, Inc. Apr 2024 - PresentCarlsbad, Ca, Us
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Director Process DevelopmentModerna Oct 2022 - Apr 2024Cambridge, Massachusetts, UsTechnical Development Team (TDT) Lead for Late Stage Therapeutics portfolio. Lead cross-functional development team in CMC commercialization for rare disease programs (PA, MMA, PKU) from pivotal to PPQ and BLA readiness activities. Led cross-functional phase 3 readiness activities for Individualized Neoantigen Therapy (INT) Program including scale out, new process introduction, analytical control strategy and qTPP definition, late-stage due diligence and regulatory authoring (IND, IMPD, FDA Briefing Document, global RtQs). Accountable for Technical program strategy, roadmap and weekly updates to senior leadership and program teams. -
Associate Director Mrna Process DevelopmentModerna Jun 2020 - Sep 2022Cambridge, Massachusetts, UsLead team of ~15 purification scientists and process engineers. Early stage mRNA Process Development lead (Upstream and Downstream Process Definition) and Technical Development Team (TDT) program lead for infectious disease programs (RSV, CMV, Zika). Definition and life cycle management optimization of plasmid DNA and RNA processes for FIH, pivotal and commercial mRNA-1273 SARS-CoV-2 vaccine manufacturing. Project lead for High-Throughput Development initiative to establish scale down models for rapid process characterization workflows.
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Senior ScientistModerna Dec 2018 - May 2020Cambridge, Massachusetts, UsTeam lead for DNA purification process development and RNA process development for personalized cancer and rapid response mRNA vaccines
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Head Of DepartmentShanghai Zerun Biotechnology Co.,Ltd. Oct 2017 - Sep 2018Pudong, Shanghai, CnLeading Shanghai Zerun's Technology Development Department in the early-stage Upstream & Downstream process development of new vaccine candidates for China and GAVI countries. Built new Team & Lab from ground up for virus-like particle characterization, upstream, downstream process development -
Project LeaderShanghai Zerun Biotechnology Co.,Ltd. May 2017 - Aug 2018Pudong, Shanghai, CnLed cross-functional team of 10 in early-stage development of next generation HPV vaccine. Gained pre-clinical proof of concept in animal model for innovative vaccine formulation.
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Senior ScientistShanghai Zerun Biotechnology Co.,Ltd. Apr 2016 - Oct 2017Pudong, Shanghai, CnLed team in Purification Department with focus on filtration & chromatography. Set-up scale-down purification model, Quality by Design toolbox, 5 process analytical technology (PAT) methods. Awarded ‘Shanghai Zerun Best Team 2017’ for cross-functional problem solving & pro-active collaboration. Developed clinical phase III downstream process step for China’s first domestic HPV vaccine. Led company’s Scientific Committee with focus on new technology evaluation and staff training.
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PostdocKarlsruher Institut Für Technologie (Kit) Oct 2015 - Feb 2016Karlsruhe, Baden-Württemberg, DeMy research field covered the process development of biologics (proteins, antibodies, vaccines) with a focus on high-throughput experimentation, mechanistic process modeling and optimization of chromatography processes. Forwarding our group's engagement in large biomolecule processing, I elaborated and coordinated research collaborations with biopharmaceutical companies and research institutes. https://www.researchgate.net/profile/Christopher_Ladd_Effio -
Ph.D. StudentKarlsruher Institut Für Technologie (Kit) Aug 2012 - Sep 2015Karlsruhe, Baden-Württemberg, DeSince 2012 I worked as a Research Associate and PhD student in the biomolecular separation engineering group of Prof.Dr. Hubbuch. Continuing my research work on purification and characterization of monoclonal antibodies, I focused on the process development of large biomolecules. My area of expertise was the development of rational development strategies and PAT tools for virus-like particles. This included the miniaturization and automation of upstream and downstream processes applying robotic high-throughput experimentation and the implementation of rapid analytical assays (UHPLC, ELISA). Another focus was laid on modeling and simulation of chromatography processes and the technology transfer to industrial partners.https://www.researchgate.net/profile/Christopher_Ladd_Effiohttps://oatd.org/oatd/record?record=oai\:EVASTAR-Karlsruhe.de\:1000052361&q=id%3A%22oai%3AEVASTAR-Karlsruhe.de%3A1000052361%22
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Visiting ScientistMerck Dec 2015 - Dec 2015Implementation of an automated high-throughput screening (HTS) platform and guest lecturer.
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Visiting ScientistThe University Of Queensland Nov 2012 - Nov 2012Brisbane, Queensland, AuTraining on processing and analytics of virus-like particles at the Centre for Biomolecular Engineering of Prof. Anton Middelberg(Australian Institute for Bioengineering and Nanotechnology AIBN) -
Research InternMerck Group Oct 2010 - Mar 2011Darmstadt, DeI worked in the process development department in Merck's Performance Materials Advanced Technologies division. My intership focused on the ‘Mobile Energy' project dealing with the development of novel lithium-ion batteries. In our team, I was responsible for the development of a purification process for lithium-ion battery electrolytes removing traces of water and hydrofluoric acid. -
Research InternCeamsa Aug 2010 - Sep 2010Porriño, Pontevedra, EsDuring the internship I worked in a team with chemical engineers, food scientists and biologists on the process development of carrageenans and pectins for food products. This included small and large scale production of carrageenans (extraction from red algae, precipitation, filtration) and characterization of carrageenans and pectins (e.g. viscosity).http://www.ceamsa.com
Christopher Ladd Effio Skills
Christopher Ladd Effio Education Details
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Hult International Business SchoolExecutive Mba -
Karlsruhe Institute Of Technology (Kit)Chemical Engineering (Dr.-Ing.)
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Karlsruhe Institute Of Technology (Kit)Chemical Engineering (Dipl.-Ing.)
Frequently Asked Questions about Christopher Ladd Effio
What company does Christopher Ladd Effio work for?
Christopher Ladd Effio works for Ionis Pharmaceuticals, Inc.
What is Christopher Ladd Effio's role at the current company?
Christopher Ladd Effio's current role is Director, Gene Editing CMC | PhD | MBA.
What is Christopher Ladd Effio's email address?
Christopher Ladd Effio's email address is ch****@****atx.com
What schools did Christopher Ladd Effio attend?
Christopher Ladd Effio attended Hult International Business School, Karlsruhe Institute Of Technology (Kit), Karlsruhe Institute Of Technology (Kit).
What skills is Christopher Ladd Effio known for?
Christopher Ladd Effio has skills like Downstream Processing, Chromatography, Processes Development, Vaccines, Virus Like Particle Processing, Biotechnology, Protein Purification, High Throughput Screening, Hplc, Purification, Filtration, Monoclonal Antibodies.
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