Roles 🟢Preclinical: Pharmacology-Toxicology Lead 🔹Managed preclinical studies for multiple AAV gene therapy programs, which included both human and animal health programs targeting aging, cardiac and metabolic indications. 🔹Acted as point of contact for academic collaborators and CROs for POC, dose finding and candidate selection studies in small and large animals models. 🔹 Presented findings of lead candidate at ASGCT (2023).🔹Worked closely with assay and product development on generation & optimization of custom assays and drug product manufacturability. 🟢Vector Optimization / Drug Design Lead 🔹Led a team to design, construct & optimize AAV GIO plasmid panels and transgene (protein engineering of custom proteins) for screening. 🔹Design and execution of in vitro and vivo candidate selection studies. 🔹Worked closely with/and participated in process development to determine manufacturability of both GIO plasmid and final AAV Drug Product (DP). In addition, assisted in optimization for scale up at external vendors.

Laboratory of Eric R. Kandel

Laboratory of Eric R. Kandel

Cellular and Molecular Neuroscience Laboratory (PI: Jonathan Ploski)

Center for Mitochondrial and Epigenomic Medicine @ UPenn/CHOP (Mentor: Douglas C. Wallace)

Systems Neuroscience Laboratory (Mentor: Diana S. Woodruff-Pak)

Neurobiological Investigations of Learning and Addiction Lab (Mentor: Tomas J. Gould)