Christopher Ecker Email & Phone Number

Los Angeles, Ca, Us

San Diego, California, Us

• Led team that performed in vitro and in vivo screens to identify lead candidate CAR configuration for undisclosed solid-tumor target.• Led team that initiated 2 novel discovery projects to enhance iPSC-CAR T resistance to solid TME and fratricide.• Manage full-time responsibilities for 4 reports (1 PhD level scientist, 2 AS, and 1 SRA.)• Discovery efforts led to 1 provisional patent filing and use in next-generation clinical stage asset.

Santa Monica, California, Us

• Developed pre-clinical assets that augment clinical efficacy or safety of primary CD19 CAR T via small molecules or genetic engineering that led to 1 patent filing.• Executed 2 screens exploring effects of 2,000 small molecules and 20 transcription factors on primary CAR T functionality.• Partnered in multiple internal cross-functional collaborations between PD, Translational Medicine, and R&D.• Generated strategies for Chronic Lymphocytic leukemia and indication-specific research strategies for next generation CAR T programs.• Manage full-time responsibilities of 3 senior research associates.

Philadelphia, Pa, Us

Thesis Mentor: James Riley, PhDPrimary Project: Identification of metabolic salvage pathways that human T cells rely on in limiting nutrient environments and how their adaptation affects their subsequent immune function. Secondary Project: Examining how mitochondrial morphology and function is altered upon T cell activation.Rotation Project: Development and testing of novel culture media formulation for optimal expansion of human T cells for adoptive T cell therapy and future clinical trials.Rotation Mentor: Arjun Raj, PhDRotation Project: Identification of a novel intercellular pathway of communication via RNA transfer.

Doctor Of Philosophy - Phd, Immunology

Bachelor Of Science - Bs, Biology, General