Christopher M Rath Email & Phone Number

Oakland, CA, US

North Chicago, Illinois, US

Emeryville, California, US

The Totus Platform discovers drugs with unprecedented volume, speed, and efficiency, allowing us to create a comprehensive catalog of drugs across the entire human genome. My team automated, developed, and executed novel screening pipelines for covalent DNA-encoded libraries. As well, my team confirmed hits via intact mass spectrometry and peptide mapping.

Pleasanton, US

Sestina Bio is a start-up in the synthetic biology space seeking to unite advances in strain engineering, analytics, and data-science to produce innovative solutions for diverse industries.

San Diego, California, US

San Diego, California, US

Ometa Labs is a leader in innovative metabolomics solutions for interrogating microorganisms and the microbiome. Experimental work is driven by a “data-first” mentality, powering algorithms and computational tools for unique insights into experiments.-Business development focused on start-up growth, and client outreach.-Development of analytical methods to.

Heidelberg, DE

EMBL is Europe's flagship laboratory for the life sciences. During my research sabbatical at EMBL, I am working with the Alexandrov team, focusing on novel computational methods for mass spectrometry data analysis.-Developing machine-learning approaches for examining fragmentation in imaging mass spectrometry datasets.-Computational workflows to link.

Vancouver, Washington, US

-Developed and executed analytical assays to support joint development agreements and feasibility studies with short-timelines at a biotechnology start-up.-Built out group and team to address growing need for in-house analytics including chromatography and mass spectrometry.-First member of Analytical Development group, eventually supervised four other.

Basel, Baselstadt, CH

-Facilitated drug development against infectious disease and oncology targets through application of advanced technologies including mass spectrometry. -In vitro biochemical assays and in cell microbial assays were developed for LCMS and high-throughput (RapidFire) mass spectrometry platforms.-Developed and executed analytical assays to support drug.

La Jolla, CA, US

-Developed new MS analytical tools to further our understanding of host-microbe interactions. -Validated unknown molecule identities by GC-, nanoDESI-, nano infusion-, and LC-MS/MS. -Automated data-analysis through extensive collaboration with computational scientists.

-Characterized natural product biosynthetic enzymes. -Purified active multi-domain enzyme complexes >500 kDa. -Elucidated protein post-translational modifications using bottom-up, middle-down, and top-down LC-MS. -Identified the biosynthetic pathway for the approved chemotheraputic ET-743.

US

-Developed assays to characterize recombinant proteins in support of Phase I and II drug development. -Developed and ran all extended characterization SDS-PAGE assays (e.g. silver-stain, western blots) for submission to FDA. -Transferred assays to regulated GLP and GMP laboratories. -Authored protocols and technical reports.

-Identified novel anti-cancer small molecules from marine sources as potential drug leads. -Purified and characterized unknown small molecules (>500 MW) using HPLC, NMR, and MS. -Developed a novel protocol for screening growth-condition dependant fungal metabolite output by LCMS.

Phd, Chemical Biology

Bs, Biochemistry And Molecular Biology