Christopher Pfleger Email & Phone Number

Frankfurt, Hesse, Germany

Düsseldorf Area, Germany

- Three years of professional experience during a collaboration with the pharmaceutical industry- Since 2017, member of the research unit FOR 2518 (Functional dynamics of ion channels and transporters)- Since 2020, member of the LipoBiocat projectIn my current research, I am studying:- studying the molecular recognition properties of catalytic sites to predict enzymes' substrate binding- how the statics in biomolecules helps to understand the role of dynamic-driven allostery- binding kinetics of GPCR ligands.- ligand-dependent signaling in GPCRs- intersubunit cooperativity in HCN ion channels.In my research, I was working on:- Co-developer of an efficient workflow for identifying cryptic sites and studying the signaling in biomolecules- Pattern recognition for classifying biomolecular binding sites

Frankfurt

Developed an automated workflow for analyzing transient pockets in protein-protein interfaces

Darmstadt

Practical semester in the department „Bio- and Chemoinformatics”- Evaluated a database for in-house X-ray crystal structures- Developed a Perl/CGI program for automatic formatting of X-ray data

Ingelheim

Research assistant during semester breaks in the fomrer department "Drug Delivery"- Analyzed the aerodynamic particle size distribution of capsules for oral inhalation - Quantified the products of chemical decomposition by HPLC-UV analyses

Ingelheim

Former department "Drug Delivery"- Analyzed the aerodynamic particle size distribution of capsules for oral inhalation- Quantified the products of chemical decomposition by HPLC-UV analyses- Documentation according to GMP guidelines- Used laboratory information management system (LIMS) for data storage

Dr. Rer. Nat., Phd Research

The topic of the thesis: "Ensemble-based framework for analyzing dynamically dominated allostery" Advisor: Prof. Dr. Holger Gohlke.

Phd Research

Development of a novel approach for analyzing free energies of cooperativity and signaling in biomacromolecules exhibiting dynamically.

Diplom (Fh), Bioinformatik

Diploma thesis done at Goethe-University, Frankfurt The topic of the thesis: “Protein-protein interfaces investigated by computer.

Laboratory Assistant