Chris Proffitt Email & Phone Number

Innovative and recognized leader driven to bring value to drug discovery teams. Proven track record and expertise within small molecule, biologic, and RNA therapeutic drug modalities including antibody-drug conjugates. Deep knowledge of cellular / molecular biology, antibody discovery, small molecule optimization, gene expression, and bioassay development. With excellent scientific understanding within liver fibrosis, inflammation / immunology, and oncology. A people-orientated self-starter with a reputation for building strong professional interpersonal relationships. Noted for ability to integrate with any team/personality. A confidence builder that fosters collaboration within discovery teams resulting in high quality outcomes. Wholly committed to timeline management, efficient execution of goals, and effecting timely go / no go decisions. Passionate to provide new therapies that improve the lives of people suffering from disease. CAREER HIGHLIGHTS• Delivered antibody-oligonucleotide conjugates to specific cell type in liver, guiding the team to targets where oligo delivery could be achieved, and gene knockdown observed. Providing guidance for in vivo studies and biomarker discovery.• Implemented in vitro cell internalization assays such as toxin delivery, FACS binding/quenching, and endosomal escape. Characterized multiple exciting targets. • Validated novel IBD target within innate immune cell pathway. Achieved project start for potential first-in-class IBD therapy with limited tools.• Enabled pre-clinical path for treatment of fibrosis, including development of target occupancy assay to guide human dose prediction. • Designed blood and cytokine assays for MOA evaluation of innate and adaptive immune cell targets, leading to project stage-gate advancement. • Optimized high-throughput assay system to identify new leads for prioritized kinase inhibitor program. Enabled go / no go team decisions for candidate nomination. Reduced data turnaround >40%.AREAS OF EXPERTISECell based assays | ELISA | MSD ELISA | Flow cytometry | RT-qPCR | Gene expression | Antibody-drug conjugate | Experimental design | Protocol Development | Flowjo | High throughput screening | Antibody discovery | Biomarkers | Ex vivo assays | Protein expression | Tissue culture | Binding assays | Immunology | PBMC isolation | Immune cell assays | Graphpad prism | Communication | Presentation | Timeline management | GPCR | RNA transcription | Oligonucleotides | Small molecule | CRO management| FACS | Fluorescence microscopy | Taqman | Cell internalization | Data analysis