Innovative and recognized leader driven to bring value to drug discovery teams. Proven track record and expertise within small molecule, biologic, and RNA therapeutic drug modalities including antibody-drug conjugates. Deep knowledge of cellular / molecular biology, antibody discovery, small molecule optimization, gene expression, and bioassay development. With excellent scientific understanding within liver fibrosis, inflammation / immunology, and oncology. A people-orientated self-starter with a reputation for building strong professional interpersonal relationships. Noted for ability to integrate with any team/personality. A confidence builder that fosters collaboration within discovery teams resulting in high quality outcomes. Wholly committed to timeline management, efficient execution of goals, and effecting timely go / no go decisions. Passionate to provide new therapies that improve the lives of people suffering from disease. CAREER HIGHLIGHTS• Delivered antibody-oligonucleotide conjugates to specific cell type in liver, guiding the team to targets where oligo delivery could be achieved, and gene knockdown observed. Providing guidance for in vivo studies and biomarker discovery.• Implemented in vitro cell internalization assays such as toxin delivery, FACS binding/quenching, and endosomal escape. Characterized multiple exciting targets. • Validated novel IBD target within innate immune cell pathway. Achieved project start for potential first-in-class IBD therapy with limited tools.• Enabled pre-clinical path for treatment of fibrosis, including development of target occupancy assay to guide human dose prediction. • Designed blood and cytokine assays for MOA evaluation of innate and adaptive immune cell targets, leading to project stage-gate advancement. • Optimized high-throughput assay system to identify new leads for prioritized kinase inhibitor program. Enabled go / no go team decisions for candidate nomination. Reduced data turnaround >40%.AREAS OF EXPERTISECell based assays | ELISA | MSD ELISA | Flow cytometry | RT-qPCR | Gene expression | Antibody-drug conjugate | Experimental design | Protocol Development | Flowjo | High throughput screening | Antibody discovery | Biomarkers | Ex vivo assays | Protein expression | Tissue culture | Binding assays | Immunology | PBMC isolation | Immune cell assays | Graphpad prism | Communication | Presentation | Timeline management | GPCR | RNA transcription | Oligonucleotides | Small molecule | CRO management| FACS | Fluorescence microscopy | Taqman | Cell internalization | Data analysis
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ScientistPfizerPoway, Ca, Us -
Scientist IiTakeda 2022 - PresentSan Diego, California, United StatesGI Liver -
Scientist ITakeda 2018 - 2022San Diego, California, United StatesGI Immunology/Inflammation 2018-2020GI Liver 2020-2022 -
Associate ScientistTakeda 2016 - 2018San Diego, California, United StatesGI Immunology/Inflammation -
Senior Research AssociateTakeda 2012 - 2016San Diego, California, United StatesOncology 2012-2013Immunology/Inflammation 2013-2016 -
Senior Research AssociateIntellikine Inc Oct 2011 - Feb 2012Oncology, in vitro biology. Acquired by Takeda
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Senior Research AssociateCylene Pharmaceuticals 2009 - 2011 -
Research Associate Ii/IiiCylene Pharmaceuticals 2005 - 2009 -
Research Associate ICylene Pharmaceuticals 2003 - 2005 -
Chemistry Lab InternCylene Pharmaceuticals 2002 - 2003
Chris Proffitt Education Details
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Biology, Concentration In Molecular Biology -
Liberal Arts
Frequently Asked Questions about Chris Proffitt
What company does Chris Proffitt work for?
Chris Proffitt works for Pfizer
What is Chris Proffitt's role at the current company?
Chris Proffitt's current role is Scientist.
What schools did Chris Proffitt attend?
Chris Proffitt attended Point Loma Nazarene University, Bakersfield College.
Who are Chris Proffitt's colleagues?
Chris Proffitt's colleagues are James H., Talles Oliveira, Steffen Schwarz, Laura Wipfler, Luca Alessandrini, Dan Filipe, 久田富美子.
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Chris Proffitt
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