Chris Proffitt

Chris Proffitt Email and Phone Number

Scientist @ Pfizer
Poway, CA, US
Chris Proffitt's Location
Poway, California, United States, United States
About Chris Proffitt

Innovative and recognized leader driven to bring value to drug discovery teams. Proven track record and expertise within small molecule, biologic, and RNA therapeutic drug modalities including antibody-drug conjugates. Deep knowledge of cellular / molecular biology, antibody discovery, small molecule optimization, gene expression, and bioassay development. With excellent scientific understanding within liver fibrosis, inflammation / immunology, and oncology. A people-orientated self-starter with a reputation for building strong professional interpersonal relationships. Noted for ability to integrate with any team/personality. A confidence builder that fosters collaboration within discovery teams resulting in high quality outcomes. Wholly committed to timeline management, efficient execution of goals, and effecting timely go / no go decisions. Passionate to provide new therapies that improve the lives of people suffering from disease. CAREER HIGHLIGHTS• Delivered antibody-oligonucleotide conjugates to specific cell type in liver, guiding the team to targets where oligo delivery could be achieved, and gene knockdown observed. Providing guidance for in vivo studies and biomarker discovery.• Implemented in vitro cell internalization assays such as toxin delivery, FACS binding/quenching, and endosomal escape. Characterized multiple exciting targets. • Validated novel IBD target within innate immune cell pathway. Achieved project start for potential first-in-class IBD therapy with limited tools.• Enabled pre-clinical path for treatment of fibrosis, including development of target occupancy assay to guide human dose prediction. • Designed blood and cytokine assays for MOA evaluation of innate and adaptive immune cell targets, leading to project stage-gate advancement. • Optimized high-throughput assay system to identify new leads for prioritized kinase inhibitor program. Enabled go / no go team decisions for candidate nomination. Reduced data turnaround >40%.AREAS OF EXPERTISECell based assays | ELISA | MSD ELISA | Flow cytometry | RT-qPCR | Gene expression | Antibody-drug conjugate | Experimental design | Protocol Development | Flowjo | High throughput screening | Antibody discovery | Biomarkers | Ex vivo assays | Protein expression | Tissue culture | Binding assays | Immunology | PBMC isolation | Immune cell assays | Graphpad prism | Communication | Presentation | Timeline management | GPCR | RNA transcription | Oligonucleotides | Small molecule | CRO management| FACS | Fluorescence microscopy | Taqman | Cell internalization | Data analysis

Chris Proffitt's Current Company Details
Pfizer

Pfizer

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Scientist
Poway, CA, US
Website:
takeda.com
Employees:
32621
Chris Proffitt Work Experience Details
  • Pfizer
    Scientist
    Pfizer
    Poway, Ca, Us
  • Takeda
    Scientist Ii
    Takeda 2022 - Present
    San Diego, California, United States
    GI Liver
  • Takeda
    Scientist I
    Takeda 2018 - 2022
    San Diego, California, United States
    GI Immunology/Inflammation 2018-2020GI Liver 2020-2022
  • Takeda
    Associate Scientist
    Takeda 2016 - 2018
    San Diego, California, United States
    GI Immunology/Inflammation
  • Takeda
    Senior Research Associate
    Takeda 2012 - 2016
    San Diego, California, United States
    Oncology 2012-2013Immunology/Inflammation 2013-2016
  • Intellikine Inc
    Senior Research Associate
    Intellikine Inc Oct 2011 - Feb 2012
    Oncology, in vitro biology. Acquired by Takeda
  • Cylene Pharmaceuticals
    Senior Research Associate
    Cylene Pharmaceuticals 2009 - 2011
  • Cylene Pharmaceuticals
    Research Associate Ii/Iii
    Cylene Pharmaceuticals 2005 - 2009
  • Cylene Pharmaceuticals
    Research Associate I
    Cylene Pharmaceuticals 2003 - 2005
  • Cylene Pharmaceuticals
    Chemistry Lab Intern
    Cylene Pharmaceuticals 2002 - 2003

Chris Proffitt Education Details

Frequently Asked Questions about Chris Proffitt

What company does Chris Proffitt work for?

Chris Proffitt works for Pfizer

What is Chris Proffitt's role at the current company?

Chris Proffitt's current role is Scientist.

What schools did Chris Proffitt attend?

Chris Proffitt attended Point Loma Nazarene University, Bakersfield College.

Who are Chris Proffitt's colleagues?

Chris Proffitt's colleagues are James H., Talles Oliveira, Steffen Schwarz, Laura Wipfler, Luca Alessandrini, Dan Filipe, 久田富美子.

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