Christopher Shriver Email & Phone Number

Bothell, Washington, United States

Led and significantly contributed to the LaunchPad plant operational startup, including: systems implementation, qualification and validation, and facility operational readinessactivities• Developed, implemented, and maintained a comprehensive integrated timeline to achieve operational readiness, including: Pharmaceutical Quality Systems, Electronic Systems, CQV, Mfg. Operations, QC Laboratories, Automation Systems, Materials Management, Facilities & Engineering, EH&S, Information Systems, and Human Resources• Coordinated and liaised with 12+ workstreams, ensuring execution planning, tracking progress and metrics, identify and escalate issues/challenges, work with the teams to provide monthly dashboard updates to Core Team, and ensured deliverables are met according to schedule.• Assumed full responsibility for all other assigned projects and ensured project(s) are delivered in accordance with site requirements and timelines.• Developed/implemented plant scheduling tools, capable of both master production plant scheduling and finite operations scheduling for both drug substance and drug product production.• Actively engaged and participated in Supply Planning meetings to ensure that plant production meets Product Supply needs for both clinical and commercial programs.• Developed business processes and guidelines for Plant Mfg. Operations that are aligned with keystakeholders.• Assisted in the generation, tracking, and adherence to Capex and Opex budgets.

Redmond, Washington, United States

• Created and maintained the Master Production Schedule• Lead S&OP and Plant Supply Review meetings• Maintained the Daily Finite Schedule• Ran Scheduling Scenarios for the Long-Range Plan• Provided Capacity Planning models to the executive team• Collaborated with multiple departments to schedule Plant Shutdowns and Facility Release • Involved with inspection/audit site readiness• Led and represented Manufacturing in functional sub-teams• Advance Continuous Improvement of Productivity and Efficiency in all Plant Operations• Provide support to client and business meetings

Bothell, Washington, United States

• Managed all stability Projects at the Seattle site as well as some of the intercompany stability projects across multiple sites• Involved with inspection/audit site readiness• Frequent communication with Subject Matter Experts to ensure timelines are kept on track• Calculate, organize and present the monthly revenue KPI’s • Developed and maintain many spreadsheet trackers for multiple projects• Organize and plan shipping requests from various departments to and from clients• Escort Persons in Plant • Document meeting minutes, set agendas and logged action items in internal and client facing meetings

Kirkland, Washington, United States

• Cell free manual DNA extraction from plasma, DNA library prep assays for prostate, lung, ovarian and breast cancers in a CLIA laboratory setting.• Targeted Next Generation Sequencing using Illumina Nextseq instruments• Data analysis for Allele frequency, common SNP’s, copy number variations and study eligible mutations.• Training lab staff on the lab assays as well as onboarded new employees to the Laboratory Information Management System (LIMS) and Lab Safety Orientation. • Served on the Safety Committee for the CLIA lab• Stocked, received and organized lab consumables as well as coordinated on what needed to be order and helped inventory supplies• Participated in IQ/OQ and calibration of various lab equipment • Actively engaged in process improvement and efficiencies to the laboratory organization and workflow

Redmond, Washington, United States

• Flexible laboratory Technologist across multiple departments performing a variety of experiments and assays on client clinical samples in a CLIA laboratory environment.• Extensive use of the LIMS system which includes: checking samples in and out, organizing samples and boxes to manage freezer space or into batches for processing or Materials Requests to be shipped off site or destroyed.• Arrays: building PRP and GRP plates using the Hamilton and Biomek robots respectively, staining, washing and scanning of WT Plus arrays on the affymetrix stations.• Library Preparation: building QRP plates on the Biomek, proficient in various Library Prep Assays: NuGen Ovation Target Enrichment, KAPA Hyper Prep, IDT Lockdown Target Enrichment, Roche NimbleGen Exome Enrichment, Illumina DNA PCR-Free, TruSeq Stranded mRNA prep, RNA Exome, Pico Mammalian and the Ambion GlobinClear prep.• Sequencing: Library Prep QC using a Bioanalyzer and qPCR, washing and maintaining the sequencers, planning Flowcells, pooling and denaturing samples, loading Flowcells on the Illumina MiSeq, HiSeq 2500 and 4000 systems, Flowcell clustering using the cBot. Sanger Sequencing using Targeted PCR, Big Dye Terminator reactions and the ABI3730xl DNA analyzer. Checking read counts and performing FastQ checks.• Quality Control: performing aliquot/dilutions and/or dry downs on samples, tube transfers, nanodrop usage, homing, checking and flushing the biomeks, executing picogreen and ribogreen fluorescent assays for DNA and RNA samples respectively, running Pico Chips on the Bioanalyzer.• Actively involved with project managers to ensure project timelines to prioritize workflows including quick turnaround projects• Engaged in the Bioinformatics and Computer Apps departments to not only learn how to better analyze the data, but to also implement process improvements and introduce more streamlined LIMS systems to the workflows.

Bothell, Washington

• Worked in the Fermentation Process Development lab dealing with Applikon 20L stainless steel Fermenters primarily with Pichia Pastoris. • Lab duties included: Wet Cell Weights, Ethanol measurements, on and offline pH measurements, taking process control parameter readings, keeping organized and well documented batch records, cell viabilities with the Cellometer, OD measurements, sampling the fermenters, cleaning and performing preventative maintenance on the fermenters, conducting shake flask experiments, producing sterile media, analyzing data, updating the database, stocking, ordering and keeping an inventory of the lab materials including for GMP and development environments, maintaining excellent aseptic technique.• Additional independent duties: Protein A concentration determination on the Octet, IgG concentration and other metabolites on the BioHT, Protein A purification on the Akta Explorer and Primes, protein concentration on the Nanodrop, SDS-Page gels, developing a contamination caller assay using a PCR, streaking and staining slides, extended microscope use. • Major Accomplishments: was part of creation of the fermentation process for Alder’s flagship molecule that was successfully tech transferred to CMOs to scale and was used in clinical trials and will continued to be used for a commercial launch, produced material for toxicology studies in a GMP environment that went into animals, completed a variety of validation experiments as well as many scale-up process experiments and participated in clone screening processes.• Used a Thermo Fisher Mass Spec to monitor vital control process parameters.• Accustomed to a GMP environment• Performed DOE experiments• Used BioExpert and Gasworks to control and operate the fermenters

Responsible for routine management and maintenance duties

Earning community service hours while performing medical related tasks at the Information Desks and Emergency Department. Earned over 550 Community Service Hours

Assisting students with quantitative related problems using math and communication skills

Organized a project of creating a medical center on Mars with sixth graders at Woodin Elementary School