Christopher Treleaven Email & Phone Number

Boston, Ma, Us

Lexington, Massachusetts, United States

• Serve as a subject matter expert and nonclinical toxicology representative on project teams.• In conjunction with program teams and senior leadership, develop toxicology strategies and provide expert support in subject area.• Work in close alignment with project leaders to provide safety strategies for novel therapeutics in our pipeline, coordinate research activities supporting project progression and decision making, and assist with the management of toxicology data for use in presentations.• Experienced in Good Lab Practices (GLP) environment to act as study monitor for GLP toxicology studies conducted at external contract research organization (CRO) sites.• Directly interface with CROs to request quotes and derive cost estimates and work closely with our Finance team to develop program budgets. Additional responsibilities include working closely with the Contracts team to develop confidentiality agreements, statements of work and track all expenses and invoices.• Responsible for all sub-vendor activities that use specialized assays and endpoints to support GLP toxicology studies.• Finalize toxicology reports and all sub-vendor reports, manage the tabular presentation of data in accordance with CTD format and have a familiarity with SEND requirements.• Maintain a general understanding of biologics and gene therapy literature, as well as the scientific literature related to the specific drug discovery projects.

Cambridge, Massachusetts, United States

Cambridge, Massachusetts, United States

o o Provided timely and resource-efficient execution of all preclinical safety activities advancing ex vivo gene therapies into Phase I/II testing.o Ensured all Preclinical aspects of IND/CTA planning are fully supported, including budgeting, contracting, program team strategy, execution of in-life studies, bioanalytical testing, and preclinical components of regulatory submissions.o Directed execution of outsourced studies including evaluated and identified appropriate CRO sites, budget and contracting, protocol creation, direct oversight of execution, and timely and accurate report generation. o Developed in vivo infrastructure; protocols, SOPs, operational processes, reporting timelines and execution, budget forecasting and management with keeping regulatory oversight in mind (FDA, AAALAC).o Directed Avrobio’s first internally run GLP-like IND enabling study resulting in robust scientific data backing the safety of our treatment for advancement of the Pompe program.o Served as an in vivo scientific technical leader for internal studies assuring accurate resource-efficient, impactful results.o Pioneered an internal in vivo review meeting with technical staff, scientists, and preclinical development ensuring cohesion in decision making.o Coordinated test article availability, animal availability, daily technical schedules (including scheduling technical support from CRO’s), and vivarium capacity to produce resource-efficient execution of studies.o Collaborated with a team in developing an integrated study management system, tying in Preclinical, Legal, and Finance teams resulting in timely and resource-efficient study management.

Cambridge, Ma

o o Directed oversight of all activities involved with running a 7000 sq ft vivarium. Controlled staffing, training, record keeping, managing of day-to-day operations and in vivo study execution.o Established in-house operations and technical staff to manage expedited growtho Designed and oversaw 1200 sq. ft. of additional lab spaceo Collaborated with scientists, preclinical team, and vivarium staff driving execution of all immune-oncology and gene editing studies.o Provided oversight for the IACUC on policy, procedures and protocol implementation.o Collaborated with facilities team ensuring vivarium physical needs were met and constant improvements being made.o Managed 12 employees across multiple disciplines: ensuring compliance, professional growth, and providing BBB support structure.o Pioneered a companywide online training program as requested by federal and local agencies.o Authored in-house policies on the use of vertebrate animals for research and the management of IACUC protocols.

Cambridge, Ma

o Managed vivarium administration and operationso Controlled staffing, training, SOP generation, in-house policies and protocol creation, record keeping, day-to-day operations, routine animal care.o Managed the needs of on-going studies ensuring coverage and accountability for all aspects within the facility.o Collaborated with biological and chemistry scientists in the design, execution, and analysis of in vivo PK and drug transporter studies supporting small molecule pharmaceuticals. o Interacted with local (Cambridge Commission) and federal agencies (DEA) resulting in consistent compliance with regulations.o Managed Neurosurgical and Neuro-Behavioral suites providing training and oversight.o Provided oversight for the IACUC on policy, procedures and protocol implementation. Acting IACUC chair.o Pioneered a companywide online training program as requested by federal and local agencies.o Co-authored 1 publication.

o Collaborated with a team in the development and validation of therapeutic strategies to target Amyotrophic Lateral Sclerosis, Angelman Syndrome, and Alzheimer’s Disease using discovery gene therapy.o Designed studies, coordinated, supervised, and assisted research teams in executing experiments and managing and analyzing data.o Organized and presented scientific data at in-house meetings and related conferences.o Expanded surgical and behavioral capabilities by validating an extensive list of behavior tests, new surgical techniques, and CNS tissue harvest methods resulting in a more comprehensive approach treatment administration and data analysis.o Co-authored 18 research publications including 2 first authorships.o Characterized SOD1 mouse model using behavior testing and biochemical analysis in the evaluation of an animal model of ALS.

Framingham, Ma

o Provided technical support for rodent studies including but not limited to rodent handling, compound administration (IP, IM, IV, ID and SC), oral gavage, retro-orbital bleeding, cardiac puncture, transcardial perfusion, necropsy Provided GLP large animal surgical support for the cardiovascular, orthopedic, and gene therapy portfolios.o Involved in all aspects of in-vivo facility logistics: animal care, technical procedures, clean and dirty washrooms, incoming animals, monitored and maintenance of breeding colonies.

Bachelor’S Degree, Business Managment, A

Associate Of Science (A.S.), Biology, General