Christopher Willits Email & Phone Number

South San Francisco, Ca, Us

Lawrence Township, Nj, Us

Lawrence Township, Nj, Us

Brisbane, California, Us

Identified and characterized the mechanism of action of cardiac myosin modulators on primary and neonatal cardiac myocytes.• Established and set-up cardiac myocyte contractility infrastructure• Determined the mechanism of action of cardiac myosin activators for on-target and off-target activities using fluorescent microscopy• Design and implement cell based assays, establish new assay tools and technologies to advance research program strategies• Investigating the response to cardiovascular drugs using iPSC-cardiomyocytes and generate methods for maturation in pluripotent stem cells

Brisbane, California, Us

Identified and characterized the mechanism of action of cardiac myosin modulators on primary and neonatal cardiac myocytes.• Established and set-up cardiac myocyte contractility infrastructure• Determined the mechanism of action of cardiac myosin activators for on-target and off-target activities using fluorescent microscopy• Design and implement cell based assays, establish new assay tools and technologies to advance research program strategies• Investigating the response to cardiovascular drugs using iPSC-cardiomyocytes and generate methods for maturation in pluripotent stem cells

Dublin 2, Ie

Neuropharmacology Experienced pharmacologist with extensive experience in nonclinical pharmacology and broad knowledge utilizing neuroanatomical and pathological techniques to investigate chronic neurodegenerative diseases.Specialties-drug discovery experience, from target identification and validation, to lead optimization.-Development of transgenic and pharmacologically induced animal models for nonclinical testing of compounds. -Neuroanatomical and pathological techniques to investigate chronic neurodegenerative diseases.-Immunohistochemistry - fresh frozen, paraformaldehyde fixed and paraffin embedded samples; animal models and human tissue-Drug administration (PO, SC, IT, IV, IP), tissue sampling and surgeries (stereotaxic, nerve axotomy, vein/artery cannulation, CSF harvest), biochemical techniques (western blotting, immunoprecipitation, ELISA), in vivo models (neuroscience, cardiovascular).- Generate large quantity of novel data using transfected/immortalized cell lines and primary neuronal cultures and incorporate into in vivo work flow.- Direct pharmacokinetic/pharmacodynamic studies for neurodegenerative diseases (Alzheimer's and Parkinson's disease).- Initiate, coordinate, design and monitor collaberations with CRO evaluating developmental compounds.- SOP and protocol writing.- Proficient in MetaMorph Microscopy Automation & Image Analysis Software, Prism, Spotfire, Microsoft Office (Excel, Powerpoint and Word), Adobe Photoshop and database management software such as ActivityBase and custom reporting applications such as Pipeline Pilot.

South San Francisco, California, Us

Pharmacology/Muscle Biology and Cardiovascular TherapeuticsEvaluate the therapeutic potential of cardiovascular and smooth muscle by using various in vitro and in vivo pharmacological approaches.Some techniques include: tissue organ bath, skinned smooth muscle preparation, Langendorff isolated heart perfusion, cardiomyocyte isolation and MOA studies. Additional experiences in cardiovascular and oncology research techniques with experiences in invasive and non-invasive assessment of hemodynamic/cardiac function and telemetry systems.