Chris Lowe Email & Phone Number

Lexington, Ma

Tokyo, Jp

• Led cross-functional process development team (encompassing cell line development, upstream PD, downstream PD, analytics, and tech transfer activities) accountable for all drug substance activities for early-stage mAb program • Facilitated successful, rapid scale up and international transfer of stable pools to 200L BRX with limited dataset providing last minute DS material in support of program timelines• Authored and coordinated updates to DS sections of IND filings to support clinical expansion• Proposed and received approval to launch new university outreach initiative, assembling a working team of 14+ technical staff to develop events and drive engagement with students at local universities to better inform and prepare them for career opportunities in the pharmaceutical industry• Simultaneous management of up to 4 direct reports including full-time contractors, co-ops, and interns

Tokyo, Jp

• Led Ph2 development for highly engineered multispecific expressed in CHO cells• Developed new upstream process with >70% increase in productivity and reduced COGs and managed successful scale up to 200L & 1000L scale internal pilot and 2000L GMP scale with external CDMO• Oversaw upstream Ph1 GMP manufacturing of 8+ batches over 2 years with external CMO including SME troubleshooting, on site person-in-plant support, and extensive review of non-english batch records• Championed development and implementation of new automated upstream tools deployed to 38+ bench scale bioreactor stations increasing throughput in the PD space & reducing hands on time for manual operations by >90%• Provided early-stage stewardship as upstream SME for an accelerated antibody drug conjugate (ADC) program through portfolio entry• Served as upstream lead for externally developed enzyme expressed in E. coli. engaging in RFP process to identify CMO partners capable of large volume DS production, managing Ph2 upstream manufacturing at partner CMO at 3,000L scale, and providing regular review of production documents and non-english batch records • Developed ATF perfusion process for Fc-fusion protein expressed in CHO cells meeting aggressive early stage program timelines• Designed and executed process development studies with AMBR15 perfusion mimic and 10L benchtop perfusion bioreactors• Successfully transferred process to 200L non-GMP pilot for tox material generation• Peer-managed leadership of weekend operations for 2+years ensuring adequate recurring staffing, recruiting and training of new weekend operators, and implementation of new workflows to improve coverage for ongoing cell culture operations, even while facing new and dynamic challenges through the COVID-19 pandemic

Tokyo, Jp, Jp

Shire is now part of Takeda (as of January 2019)

New Brunswick, Nj, Us

• Pioneered and qualified a novel, widely amenable biomaterial approach for targeted drug delivery leveraging pathophysiology cues native to injured and diseased tissues across a wide variety of conditions • Established and maintained critical collaborations for multi-disciplinary research projects informing new directions, leading to new funding opportunities, and contributing to the continued development of innovative therapies• Developed and troubleshot assays to screen interaction of free radicals with specific functional groups and cell types• Design and development of novel hydrogel biomaterials for tissue engineering applications, particularly focused on therapeutic approaches for traumatic brain injury and peripheral nerve injury• Developed a method for simple, rapid fabrication of collagen scaffolds with highly aligned topographies applicable to a variety of engineered tissue types• Functionalization of collagen hydrogels with covalently grafted, neurologically relevant peptide mimics of neurotrophic factors• Evaluated the response of primary neurons, neural stem cells, and other cell types to peptide grafted collagen hydrogels in in vitro models of injury• 2000+ hours of cell culture experience with primary and immortalized mammalian cells• Trained and mentored 8+ undergraduate students from various backgrounds on cell culture and biomedical research who have gone on to present their work at local and national conferences• Work has resulted in 14 conference presentations (10 poster, 4 oral), 4 publications, 3 successful research grant awards totaling $371,735, and a nonprovisional US patent filed in June 2018

Rahway, New Jersey, Us

• Shadowing experience with engineers and operators throughout Merck’s Kenilworth biologics pilot plant (80 hours) facilitated by Rutgers iJOBS program• Familiarized with upstream & downstream pilot operations from 2L to 500L scale including scale down models, 2L bioreactors, culture, harvest, purification, and tech transfer of biologics from pilot site to commercial manufacturing• Mentored in process development, scale up, and tech transfer activities characteristic of biologics development

• As Shift Supervisor, charged with oversight of campus security operations throughout the night managing a staff of 65 employees on shift, coordinating with campus and local emergency responders, and taking an active role in crisis management. • As Head Coordinator, charged with hiring, training, and scheduling a staff of sixty supervisors and monitors while ensuring adequate posting coverage throughout campus.

Lawrence Township, Nj, Us

• 6 month co-op experience at large scale GMP biologics manufacturing facility preparing for production.• Managed implementation of new plant steam valves to improve temperature control on 15 large scale bioreactors • Monitored tuning of temperature control valves through DeltaV and generated qualification reports with PI historian • Performed volumetric flow rate analysis to reduce WFI cycle times throughout plant, conserving water and utilities• Assisted in the validation of Steam in Place (SIP) circuits for sterilization of GMP manufacturing equipment • Managed review and updates of P&ID drawings to reflect revised circuits following CIP and SIP qualification• Trained in Good Manufacturing Practices (GMP)

Alexandria, Va, Us

•Summer intern for a series of 10-12 week research projects at UMass Amherst (2008), University of Akron (2009), Arizona State University (2010), and Rutgers University (2011) sponsored by the National Science Foundation's Research Experience for Undergraduates Program• At UMass Amherst, worked in the lab of Dr. James Watkins engineering photo-patternable porous carbons from block-copolymer thin films.•Skills Acquired: Small Angle X-Ray Scattering (SAXS), X-Ray Diffraction (XRD), Spin Coating, Photolithography•At University of Akron worked in the Department of Polymer Engineering in the lab of Dr. Kevin Cavicchi, synthesizing a novel coil-side chain crystalline block co-polymer and characterized it’s thin film morphology•Skills acquired: Reversible Addition Fragmentation Chain Transfer (RAFT) polymerization, Scanning Force Microscopy (AFM), Size Exclusion Chromatography (GPC), Proton Nuclear Magnetic Resonance Spectroscopy (1H-NMR), Dynamic Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA)•At Arizona State University worked in the Department of Chemical Engineering in the lab of Dr. Kaushal Rege at an NNIN sponsored REU site developing gold nanorods as a therapeutic to induce hyperthermic cell damage and death•Skills acquired: Cell Culture (PC3 Prostate Cancer Cells), Seed-Growth Nanoparticle Synthesis, Fluorescence and Absorbance Biological Assays for Total Protein Content (BCA) and Transfection Efficacy (Luciferase)•At Rutgers University worked in the Biomedical Engineering Department in the lab of Dr. Prabhas Moghe engineering bioactive microenvironments for neural stem cells from electrospun polymers scaffolds and carbon nanotubes.•Skills Acquired: Electrospinning, Stem Cell Culture (Neural Stem Cells), Cellular Viability Assays (Live/Dead, Alamar Blue), Immunocytochemistry and Fluorescent Imaging

Bachelor Of Science - Bs, Chemical Engineering

Bachelor Of Science - Bs, Biochemistry And Molecular Biology

Doctor Of Philosophy (Phd), Biomedical Engineering

Masters Of Engineering (M.Eng), Biomedical Engineering

High School Diploma

Education record