Cindy Cheung Email & Phone Number

Union City, CA, US

Menlo Park, California, United States

- Monitored and recovered CLIA laboratory NGS metric failures from two clinical sites (5000+ tests/week); implemented innovative mitigation efforts to prevent further decay and determined root cause through investigative datamining and studies in routine or tiger team urgent setting- Design new quality control methods for reagents and alternative materials.

Redwood City, California, United States

- Designed and executed feasibility, development, validation studies to troubleshoot, improve, and support existing fully automated G360 sequencing oncology assay (IVD/RUO/LDT) by introducing new/optimized testing processes and materials. Lead study design, execution, data analysis, SOP drafts/approvals, and interdepartmental communications with Quality.

Pleasanton, California, United States

• Perform various feasibility and optimization experiments to improve the current library preparation protocol, thereby developing an improved IVD, fully automated sequencing NGS oncology assay on the Illumina platform
• Conduct large scale, cross-platform study to compare the performance of various commercially available automated sample extraction platforms and their ability to generate quality nucleic acids for library preparation
• Carry out validation studies to optimize new… Show more
• Carry out validation studies to optimize new materials for use in the library preparation protocol of the IVD oncology NGS sequencing assay in development and improve internal workflows to ensure best performance
• Execute and coordinate cross-functional bridging studies and analyses between Development and Bioinformatics colleagues from different sites
• Proficient in Illumina systems operations; hands-on in NGS library construction and quality control using Illumina’s MiSeq, NextSeq, NextSeqDx, and NovaSeq systems

Pleasanton, California, United States

• Performed feasibility, optimization, and proof-of-concept experiments for a target capture method to enrich for nucleic acids in bacterial and fungal species in blood
• Designed and performed feasibility and proof-of-concept experiments for DNA/RNA extraction from bacterial and fungal species in whole blood to be transferred to a fully automated sample extraction and amplification.
• Designed and performed assay feasibility and optimization experiments to develop an IVD, high… Show more
• Designed and performed assay feasibility and optimization experiments to develop an IVD, high throughput, and fully automated RT-qPCR rapid sepsis detection and identification assay in blood on the cobas® 68/8800 Systems
• Present findings at high level cross-functional project team meetings, internal and external meetings, and hold regular companywide seminars Show less

Pleasanton, CA

• Participated in the research and development of cobas® ADCY9 Genotype Clinical Trial Use (CTA) and IVD level qPCR Assay for cardiac patient companion diagnostic use with leader role in conducting large scale.
• Independently planned and carried out oligo design, screening, optimization, and guardbanding feasibility studies for development of multiple CAP-CLIA/RUO RT-qPCR Assays detecting RNA fusions and exon skipping for lung.
• Independently planned and carried out oligo design, screening, optimization, and guardbanding feasibility studies for development of multiple CAP-CLIA/RUO RT-qPCR Assays detecting RNA fusions and exon skipping for lung.
• Designed and performed feasibility and proof-of-concept experiments for a method to concentrate of exosome-containing conditioned media from cell lines
• Designed original, high performance primers/probes for droplet digital PCR and amplicon-based NGS for use as reference methods for various RT-qPCR assays
• Collaborated and communicated closely with cross-functional teams such as Business, Systems, Manufacturing, Operations, Quality, and Regulatory

Pleasanton, CA

• Participated in design input research and assay development of an IVD cobas® EZH2 Mutation Detection qPCR Kit for lymphoma diagnostic use; independently designed and performed assay optimization and guardbanding.
• Worked independently in the development of an updated RUO cytomegalovirus (CMV) qPCR assay on an automated PCR c6800 platform
• Completed proof-of-concept testing to expand the CMV qPCR assay to use additional sample types such as urine and saliva to allow for… Show more
• Completed proof-of-concept testing to expand the CMV qPCR assay to use additional sample types such as urine and saliva to allow for easier sample collection in Genentech clinical study with neonates
• Trained 1 student intern with laboratory techniques, experimental designs, data analysis, presentation, and career growth discussions Show less

Fremont, CA

• Designed validation plans and conducted company wide study efforts to rapidly investigate and successfully mitigated the failure of IVD therapeutic drug monitoring assay reference standard products which caused.
• Project Leader in cross department process and material validation studies to design, manufacture, qualify, and incorporate benchmark anchor/master calibrators into various therapeutic drug monitoring (TDM) IVD.
• Project Coordinator to… Show more
• Project Coordinator to design and conduct process validation studies to troubleshoot issues in various products; conducted troubleshooting and investigations to analyze causes of product failures and to design product.
• Experience in handling various formal processes including customer complaints, recording non-conformances, drafting/executing CAPAs, drafting validation/verification studies, addressing FDA concerns and audits
• Transferred knowledge of various protocols from colleagues in a 3 week long training in Indiana and effectively cross trained various departments upon return

Fremont, CA

• Performed confirmation testing of raw materials to ensure performance of final products in clinical diagnostics
• Designed and executed official cross-departmental material validation testing plans/studies to assess for changes in product performance with new materials and to implement new materials for use in IVD products

Pleasanton, CA

• Performed feasibility and optimization experiments in the development of an IVD RT-qPCR test to detect vascular endothelial growth factor subtypes in lung tissues for companion diagnostics
• Executed assays in high-throughput format by creating custom Biomek liquid handling system protocols using VBscript
• Created data import/analysis VBA Excel macros to increase accuracy and efficiency

Hayward, CA

• Participated in the development of a simultaneous DNA/RNA/miRNA extraction product suitable for frozen and FFPE tissues
• Mastered intraocular injection techniques on murine eyes and other surgical techniques; specifically trained from collaborator in Texas and effectively cross trained colleague groups upon return for further research.
• Designed and conducted quantitative, fluorescence cell-based assays for calcium-rich cell line validation and quality control; drafted… Show more
• Designed and conducted quantitative, fluorescence cell-based assays for calcium-rich cell line validation and quality control; drafted formal QC SOPs for the validation and quality control for formal product release.

Pleasanton, CA

• Performed whole genome high-throughput DNA amplification to develop a quantitative qPCR RUO assay to quantify DNA methylation in human FFPE tissues
• Utilized high-throughput liquid handling systems to carry out experiments by programming custom methods using VBscript for Biomek Systems Software

Irvine, CA

• Conducted research on interactions of dopamine D2 receptor with G protein subtypes upon signal influences by detecting multi-DNA/protein targets with in-situ hybridization and immunohistochemistry
• Conducted research on potential multi-meric activation induced cytidine deaminase (AID) in antibody diversification and protein-protein interactions of cell death protein FADD with autophagy protein atg5

San Diego, CA

• Conducted research on the role of ATP and adenosine on T cell function using techniques such as ELISA, SDS-PAGE, and flow cytometry with minimal supervision
• Developed protocols to quantitatively and spatially measure real-time calcium level changes in T cells using fluorescence microscopy

Ms, Biological Sciences

Bs, Biochemistry & Cell Biology; Psychology (Biopsychology/Signal Transduction)