Cj Williams Email & Phone Number

Cypress, Tx, Us

Houston, Texas, United States

Projects: Texas Genomics Consultants, UK Biobank Genomics Research Project | Nov 2022 to Present- Built genomics pipelines on UK Biobank’s Research Analysis Platform to efficiently filter and annotate variants across 400K+ exomes- Implemented data transforms utilizing Matrix Market Format to support processing of large, sparse genotype matrices- Constructed Nextflow processes to perform ancestry analysis, PRS calculations, and GWAS simulations for model construction- Created suite of R scripts to perform and present primary experimental analysis for upcoming publicationsTexas Genomics Consultants, Platelet Liquid Biopsy Data Analysis | May 2021 to August 2023- Cleansed RNA-seq biomarker data to provide solid foundation for analysis- Applied standard statistical and genomics packages to control for confounding variables in dataset- Utilized lasso regression and multi-level cross-validation to create performant predictors for use in validating novel IP- Created four predictor models with logistic regression techniques to predict disease with gene-level expression, showcasing Receiver Operator Characteristics (ROC) to demonstrate model performanceTexas Genomics Consultants, Proof of Concept Development | May 2021 to March 2022- Developed genomics processing and reporting proof of concept using Python and GenomeOncology API- Created three independent pipelines to identify genetic risks for disease and drug responses using clinvar ACMG annotations, ancestry imputation and Polygenic Risk Score quantification- Designed modules to consume GenomeOncology’s KMS APIs and generate dynamic clinical assertions- Built reporting system using Jinja and NodeJS to render clinical-grade reports for review by scientific professionals towards finalizing proof of concept

Houston, Texas Area

Projects:Spruce Power, Data Warehouse Maintenance | January 2020 to March 2021 - Maintained, updated, and improved Microsoft-based data warehouse solution by identifying issues and building out technical additions to meet business needs- Served as a Technical Owner for a live data warehouse supporting all company business units in report compilation- Monitored AWS, Microsoft, and Google administrator resources to maintain security, performance, and reliabilityRecipe for Success, Mobile App Re-Architecture | July 2019 to September 2019- Re-built Angular application in React to support Ionic framework updates- Diagnosed and resolved fatal compatibility issue between updated Android and Ionic in existing cross-platform mobile application by building a mock application using existing framework to verify problem from error messageBaylor Genetics, Genomics Pipeline and Review System | July 2018 to July 2019- Established warehousing pipeline and variant review backend for novel Whole Genome Sequencing test- Productionalized genomics analysis pipeline for commercial use using GenomeOncology API & custom Python modules- Directed team of three in development of genomics trio case management REST API using Flask, MongoDB and marshmellow to support medical testing and research- Documented and tracked system requirements and application scope throughout the project to determine limits and functionalities

Houston, Texas Area

Developed and deployed custom web, data analysis, and reporting solutions for whole genome sequencing tests.Highlights:- Served as Lead Developer for non-invasive prenatal screening test by creating full-stack web application for genetic variant review with Java Spring and Javascript- Built tertiary analysis pipeline for pre-natal, de novo variant detection in Python and incorporated annotations into review system from multiple sources (e.g, dbSNP, GNOMAD, ClinVar, etc.) for comprehensive review- Facilitated “Introduction to Python Development” workshop for six students to learn foundational skills and language applications

Houston, Texas Area

Added features, improved existing functionality, and fixed bugs on SnapSteam's live video clipping solution built on the .NET stack.Highlights:- Implemented features and resolved bugs in .NET and Android systems for more reliable end-user experience- Completed projects following waterfall development workstream to meet delivery deadlines, budgets, and assignment specifications - Co-led development of greenfield Android TV “set-top box” application for commercial customer use and designed preliminary live streaming capabilities using RTMP and libVLC- Developed a TV streaming Android application with HMAC authentication and rendezvous registration

Houston, Texas Area

Quickly learned and applied modern technologies and methodologies at client sites to develop custom software solutions to solve business problems. Worked on small teams across various industries including retail energy, finance, and agribusiness.Highlights:- Completed requirements gathering, market research, and vendor analysis, resulting in successful kickoff of multiple commercial software integrations - Improved accuracy of marking campaigns 9x through development of C# tool with SmartyStreets API- Re-platformed genetic research management app to .NET MVC, improving data integrity and workflow speeds for agribusiness research lab- Re-architected MSSQL enterprise ETL processes to improve performance and data quality

Bioscience Research Collaborative

Worked under Dr. Oleg A. Igoshin to mathematically model a gene regulatory network responsible for definitive blood stem cell development in the mammalian embryo. Used results from in silico experiments on gene perturbations to reconcile previously unexplained experimental results in the literature.See publication: https://pubmed.ncbi.nlm.nih.gov/23623899/