Clare Dong Eun Kim Email & Phone Number

South San Francisco, California, Us

Translational Medicine OMNI Biomarker

South San Francisco, California, Us

Disease Signature In Vitro Lab in Translational Immunology Department - conduct and develop relevant in vitro and ex vivo measurements of endpoints for preclinical in vivo models. - Exploit multi-omics technologies and integrate these into existing and developing databases to evaluate disease signatures in preclinical models and map them to clinical samples.

South San Francisco, California, Us

Novato, Ca, Us

• Project 1: Identified that TNFalpha secreted from senescent cells switches cell fate to apoptosis in premature aged ERCC1-deficient mice • Project 2: Investigate the role of senescent cells in the reprogramming and tissue rejuvenation using 3D skin organoids and aged mouse model • Project 3: Study the causative role of senescent cells in keloid (skin fibrosis) - Characterize cellular senescence using IHC/IF techniques in human patient samples with keloid in collaboration with clinicians in Massachusetts General Hospital.

Lausanne, Vaud, Ch

teaching Students in the couse of Biochemistry Lab. for 2nd year Medical School Students (Professor Pascal Schenider)

Lausanne, Vaud, Ch

• Determined the role of CSL (a Notch effector) and p53 in senescence overcome and CAF (cancer-associated fibroblast) activation using human premalignant and malignant skin tumors and mouse skin field cancerization model. • Identified the role of ATF3 (a stress responsive transcription factor) in control of specific chromatin modifications for CAF activation in human clinical samples and mouse model using combination of RNA-seq and ChIP-seq. • Discovered a phamacological drug to epigenetically modify chromatins and suppress cancer-associated fibroblasts (CAF) in skin cancer, based on transcriptomics and epigenomics data. • Set up protocols for several challenging techniques including tumorigenecity assay, single cell-based laser capture microdissection (LCM) and sample/library preparation of RNA-seq and ChIP-seq. • Developed a bioinformatic tool to display differential binding sites of ChIP-seq data in collaboration with a bioinformatician.

Pittsburgh, Pa, Us

• Discovered a molecular link between ATE1 (R-transferases) of N-end rule pathway (a unique proteolytic system) and Gq in cardiovascular system using a double mutant mouse model lacking ATE1 but overexpressing Gq protein• Designed, generated and characterized a transgenic mouse model specifically overexpressing RGS5 in vascular smooth muscle

Pittsburgh, Pa, Us

Proctoring and grading exams in the following courses- Pharmacotherapy of Infectious Disease 1& 2 (Professor Paul Schiff)- Drug Development 2 (Professor Samuel Poloyac) - Biochemisty (Professor Barry Gold) - Pharmacotherapy: Neurology and Psychiatric (Professor David Edwards) - Pharmacotherapy of cardiovascular disease (Professor Regis Vollmer)

Seoul, Kr

Optimized long-term culture condition for primary isolated endothelial cells from porcine aorta and characterized cellular integrity and function using histological and FACS analysis to understand immune rejection between porcine endothelial cells and human blood during xenotransplanation.

Doctor Of Philosophy (Phd), Cancer And Immunology

Master In Pharmaceutical Sciences, Pharmaceutical Sciences

Master In Science, Stem Cell Research In Dental School

Bachelor Of Science (Bs), Plant Sciences