Clare Leguyader Email and Phone Number

• Project lead to design and evaluate injectable depot formulations for long-acting HIV pre-exposure prophylaxis, focused on end-user design parameters. • Developed and established HPLC and LC-MS/MS methodologies for in vitro and in vivo assays to evaluate drug release profiles and pharmacokinetics.• Led team efforts to obtain key experimental data, secured next-round funding from funding agency (Bill and Melinda Gates Foundation) to evaluate lead Malaria therapeutics. • Facilitated technology transfer to collaborators at other Universities and Contract Research Organizations.• Excellent scientific communication through written reports, in-person team meetings, and regular teleconferences with funding agency.• Manage and design independent research and mentor graduate and undergraduate students towards their thesis.• Polymer and Nanoparticle synthesis, characterization: NMR, GPC, SEC, DLS, TEM, AFM• HPLC, LC-MS and MS/MS methodologies for bioanalytical assays: focus on small molecules• In vivo rodent models and procedures, including safety and toxicity protocols• In vitro aseptic cell culture techniques; flow cytometry analysis and cytotoxicity assays• Pharmacokinetic study design and evaluation of ADME properties of lead API formulations

•Synthesis and characterization of novel polymers and polymer self-assemblies directly incorporating MRI contrast agents via ring opening metathesis polymerization with applications for in vivo imaging and analysis•Led collaborative efforts with in vitro, in vivo and ex vivo studies to evaluate efficacy of nanomaterials in biodistribution studies•Worked collaboratively with the Gianneschi group and an outside company to develop a new platform technology for drug delivery using serum proteins; studied cytotoxicity using in vitro cell culture methods

Organic Chemistry I and II (Chem 140A, 140B), •In-class instructor for organic chemistry discussion sections •Facilitated discussion sessions to complement main lectures using active learning techniques•Wrote quizzes and examinations to evaluate understanding of key chemical conceptsOrganic Chemistry Lab I (Chem 143A)•Maintained safe working and learning environments for students of a variety of experience levels•Presented and explained lab techniques through hands-on instructions and demonstrations•Assessed learning objectives through quizzes and written lab reports

Research Advisor: Professor Elizabeth Harbron•Synthesized rhodamine-derived polymer nanoparticles for detection of mercury ions in aqueous solution