Claudia Boldrini Email and Phone Number

Scientific Advisor trainee

My research project focused on post-translational modifications of proteins (PTMs) from pancreatic cells in the context of type 2 diabetes mellitus. Obesity and diets rich in saturated fatty acids are important risk factors in the pathogenesis of such disease, since they trigger a series of events known together as lipotoxicity. These negative events appear to be mediated by PTMs and in particular by lysine acetylation, which is usually tightly regulated and senses the metabolic state of the cell. My project aimed to understand whether saturated fatty acids may cause pancreatic beta cell impairment through the involvement of lysine acetylation, with a particular focus on mitochondrial proteins.