Clinton Dawson Email & Phone Number

Amesbury, Ma, Us

Massachusetts, United States

In my role as Senior Scientist I at Endolytix Technology, I bridge strategic vision with operational execution, managing scientific teams and spearheading assay development and nanoparticle characterization. I act as a liaison between the CSO and the development team, overseeing project completion and coordinating collaborations with CROs and external partners. Some of my key accomplishments include:➛ Developing and optimizing an automated high-throughput screen (HTS) for infection assays, leading to the identification of lead candidates for pre-IND studies.➛ Leading the successful design and execution of preclinical studies in novel mouse models of NTM infection, demonstrating the safety and efficacy of drug candidates.➛ Implementing electronic lab notebooks (ELNs) within the company, streamlining data management and ensuring compliance with FDA requirements for regulatory submissions.➛ Collaborating with external partners to transfer technology and establish industrially feasible processes, facilitating seamless integration of research findings into future development efforts.➛ Contributing to the development and optimization of methods for biophysical characterization of nanoparticles, enhancing understanding of drug delivery mechanisms and efficacy.

Fort Collins, Colorado, United States

As a Post-Doctoral Researcher at Colorado State University, I conducted preclinical trials for vaccine development and drug discovery in tuberculosis (TB) and COVID-19. Some highlights of my responsibilities and accomplishments include:➛ Leading preclinical vaccine trials in TB and COVID-19 models, providing critical insights into vaccine efficacy and immune response.➛ Conducting high-throughput screenings of new small-molecule drug compounds for the TB drug discovery pipeline, identifying potential lead candidates for further development.➛ Designing and executing drug susceptibility studies, employing advanced sequencing techniques to elucidate mechanisms of action of novel drug compounds, contributing to the development of new treatments for TB.

Fort Collins, Colorado, United States

During my time as a Graduate Research Assistant, I focused on advanced molecular research to understand gene regulation and host-pathogen interactions, with a particular emphasis on tuberculosis. Some key responsibilities and accomplishments include:➛ Building a dual-reporter vector for functional analysis of protein-DNA and RNA-RNA interactions, enabling in situ analysis of molecular interactions.➛ Optimizing extraction, purification, and quantification methods for recombinant proteins, enhancing efficiency and accuracy in downstream analysis.➛ Developing knockdown and knockout strains of M. tuberculosis using genetic recombineering, facilitating studies on gene function and pathogenesis.➛ Designing and executing infection studies with human- and mouse-derived cell lines, and in vivo, contributing to understanding of host-pathogen interactions.➛ Establishing assays for protein-DNA and RNA-RNA interactions, providing insights into molecular mechanisms underlying pathogenesis in Mycobacterium tuberculosis.

Fort Collins, Colorado, United States

-Assisted graduate-level course, Functional Genomics, teaching how to apply bioinformatics tools, WGS, transcriptomics-based approaches, proteomics workflows, and metabolomics in design and execution of experiments.-Guided lab portion of graduate-level course, Functional Genomics, teaching experimental workflows, from extracting and purifying DNA/RNA, and proteins to running NGS analysis pipelines.-Assisted graduate-level lab course, Virology and Cell Culture Lab, with hands-on experience in propagating, isolating, and characterizing DNA/RNA viruses, as well as in viral diagnostics and cell culture.

Baltimore, Maryland, United States

In earlier roles, I contributed to various research projects and collaborations, showcasing adaptability and impact in research roles. Some highlights include:➛ Publishing research papers reflecting productive collaboration and expertise in the field.➛ Playing a pivotal role in establishing partnerships with industry leaders, demonstrating strategic acumen and business development skills.➛ Transitioning from mundane contract research tasks to spearheading critical projects analyzing animal toxicity studies, contributing directly to companies preparing for clinical trials.

Cambridge, Massachusetts, United States

-Helped lead R&D efforts of ~20-person start-up to achieve overall goal of creating surface chemistries, resistant to thrombosis and biofilms to apply to biomedical devices.-Aided in design of safety and efficacy studies of lead surface chemistries with CRO using rabbit and mouse models of biomedical device-associated infections.-Designed and executed screens of lead surface chemistries to coat medical devices, testing antibiotic drug susceptibility against A. baumannii, E. coli, P. aeruginosa, S. aureus, and S. epidermidis, with fluorescent and luminescent cell-based assays, CLSM, and scanning electron microscopy (SEM) in bioreactors, 96-and 384-well plates, and laminar flow devices.

Bedford, Massachusetts, United States

-Led R&D efforts of Microbiology by example to complete safety and efficacy testing of pharmaceuticals and biomedical devices under GMP guidelines, following SOPs.-Assisted in coordinating and executing large preclinical animal studies involving multiple departments to meet critical deadlines in fast-paced CRO.-Cultured non-human and human-derived cell lines for cytotoxicity testing of biopharmaceuticals, according to GMP guidelines, following SOPs.-Performed ELISAs,following GMP guidelines, for non-human primate immuneotoxicity studies profiling antibody titers to drug candidates entering Phase I cliniical trials.

Doctor Of Philosophy - Phd, Medical Microbiology And Bacteriology

Bachelors Of Science, Medical Microbiology And Bacteriology