Christian Marin-Muller Email & Phone Number

Dover, Delaware, Us

Houston, Texas, Us

RNAi-based therapeutics with an emphasis on pancreatic cancerCathy Yao LaboratoryMichael E. Debakey Dept. of SurgeryDepartment of Molecular Virology and MicrobiologyBaylor College of MedicinePostdoctoral Associate (Former Graduate Student), Qizhi Yao Laboratory-Studied the molecular mechanisms that give rise to pancreatic cancer pathogenesis in vitro and in vivo with an emphasis on therapeutic development using nanoparticle-based delivery of oligonucleotides-Examined clinical relevance of tumorigenic factors to identify a nucleic acid and protein biomarker signature of pancreatic cancer, as well as functional effects of RNAi and virus-like particle (VLP) treatment and on cancer cells and cancer stem cells in vitro and in vivo. A patent has been filed for my work.In vitro experience in: cancer/ cell culture; functional assays of tumorigenesis; cloning and construct generation; HLA typing; in-situ hybridization; VLP production; Southern, northern and western blotting; high throughput sequencing; microfluidics; RNAi; qPCR; immunohistochemistry; HPLC; flow cytometry; ChIP; etc.; design and generation of polymer nanoparticles for the delivery of miRNA/siRNAIn vivo experience with both subcutaneous and orthotopic mouse models, including injection, surgery, and tissue collection and analysis; human patient tissue and blood sample analysis.Research Assistant, Paul Ling laboratory: studied murine gammaherpesvirus (MHV68) as a model for the mediation of intrinsic cellular host defense responses against virus infections.Teaching Assistant, General Virology (Graduate Level Course)

-Design and implementation of experiments for HIV non-nucleoside inhibitor vaccine development in vitro and in vivo (rabbits), including BSL 3 HIV manipulation (p24 ELISA, virus titration, UV-mediated viral inactivation, infection, collection, and electron microscopy visualization and testing of infectious virus).

Us

· Developed original concept and corresponding business plan and business model.-Conducted market research that allowed for the definition of a business model and product line determination. -Formed collaborative partnerships with overseas manufacturers in China, India, and the Middle East, as well as within the United States.-Coordinated domestic and international operations of the company: Negotiated orders and shipments with manufacturers and suppliers. -Responsible for distribution agreements with dozens of companies in both the U.S and abroad. -Managed licensing agreements and exclusive distribution portfolios with private biotechnology companies for proprietary products and technologies.-Managed and trained sales personnel-Coordinated warehouse shipping and logistics activities. Served as liaison between investors and customers. -Responsible for website/catalog design and development.-Evaluated several proprietary technologies and helped take them to market. -Acting sales representative and manager of sales team; built customer relations and provided customer service and support. Developed customer base to include over 600 customers in research laboratories and companies throughout the U.S.

· Developed a strategic growth plan for the orthopedics company. Conducted market research and financial forecasts for the company's proprietary CAD/CAM software. Completed detailed financial and operational plans to enable expansion and define a new direction for the company.

Instructor, Cell Culture Development Protocols Workshop-Developed and taught course to NASA Glenn Research Center biologists and engineers on cell culture protocols, sequencing, and mutation detection procedures, including laboratory demonstrations of several proprietary technologies with a focus on the commercialization aspects of cell culture development along with the latest applications of prokaryotic and mammalian cell culture in both industry and the basic research laboratory to expand NASA's involvement in biotechnology applications.

Ph.D, Molecular Virology And Microbiology

Ms, Biotechnology-Focused Entrepreneurship

Bs, Molecular Biology