Christie Mortales Email & Phone Number

Seattle, Washington, Us

Seattle, Wa, Us

Seattle, Wa, Us

- Collaborate cross-functionally with project management and legal teams to build comprehensive data packages for patent filings and publications.- Established 12+ multicolor flow cytometry panels, including analysis of tumor-infiltrating leukocytes (TILs) from syngeneic tumors (e.g., B16F10, CT26).- Develop and optimize in vitro assays to characterize various immune cell subsets' signaling profiles and effector outcomes (e.g., cytokine production, cytotoxicity, proliferation) for various programs.- Assist in managing projects outsourced to external CROs.- Engage with the lab operations team to procure reagents and equipment.

I conducted FDA regulatory affairs research for biotech/pharma clients interested in gaining insight on current and ongoing FDA initiatives, guidances, and policies to help inform strategic regulatory decisions.

Irvine, Ca, Us

I investigated how the stability of a molecular network, called the galectin-glycoprotein lattice, on the surface of immune cells (i.e., T and B lymphocytes) regulates central tolerance, "behavior" and interactions, and the outcome of autoimmune diseases.- Conducted in vitro assays to analyze how degree of N-glycan branching regulates B cell antigen-presenting cell (APC) function through TLR or CD19-BCR downstream signaling towards NFkB activation, expression of co-stimulatory molecules, cytokine production, and induction of CD4+ T cell differentiation into TH1, TH17, and TREG cells- Generated and maintained transgenic mouse colonies to study the phenotypic outcomes of N-glycosylation enzyme deletion in lymphocytes- Utilized the experimental autoimmune encephalomyelitis (EAE) mouse model to assess the effects of B cell specific N-glycosylation enzyme deletion in neuroinflammation- Presented experimental results and project progress in lab meetings, department research-in-progress talks, and scientific conferences using poster or PowerPoint format- Co-wrote manuscripts, RO1 NIH grant proposals, and animal use protocols- Supervised and mentored undergraduate students

Seattle, Wa, Us

I investigated novel immunotherapy strategies involving targeting a patient's epigenetically modified solid tumor cells with engineered autologous cytotoxic T cells.- Generated, expanded, and maintained transgenic TCR-T cells- Generated and maintained patient-derived xenografts (PDX) from primary colorectal tumor cells in NSG mice- Assessed antigen specific TCR-T cell cytotoxicity in vitro against HLA-A matched cancer cell lines utilizing 51Cr release and real-time electrical sensing assays- Planned and executed experiments; generated and analyzed data- Managed patient sample database and lab reagents/supplies inventory

Certificate, Project Management

Ph.D, Biomedical Sciences - Immunology

Bachelor Of Science (Bs), Cellular, Molecular, And Developmental Biology

Certificate, Science Of Clinical Outcome Assessment In Medical Product Development